[Comparative study of the acute and chronic effect of disopyramide and procainamide in ventricular extrasystole over a long time].

PubMed (1982)

D Bracchetti F Naccarella Beatrice Mantovani M Palmieri C. Lamberti Romano Zannoli Malini Pl B Magnani

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Keywords:

Disopyramide

Procainamide

Topics:

Cardiac Arrhythmias and Treatments

Cardiovascular Function and Risk Factors

Neurological disorders and treatments

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A comparative study of disopyramide and procainamide in the treatment of myotonia in myotonic dystrophy.

Journal of Neurology Neurosurgery & Psychiatry (1982)

Michael Finlay

Ten patients with myotonic dystrophy were allocated at random to treatment with disopyramide and procainamide in a cross-over trial. Disopyramide was found to be at least as effective as procainamide in the relief of myotonia; and two patients who could not tolerate procainamide both tolerated disopyramide.

Disopyramide

Procainamide

10.1136/jnnp.45.5.461

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Citations (20)

Effects of procainamide and disopyramide on long chain acyl carnitine and long chain acyl CoA concentrations in the ischemic heart.

Japanese Heart Journal (1988)

Akira Kobayashi Hiroshi Watanabe Noboru Yamazaki

Though the efficacies of procainamide and disopyramide in treating arrhythmias are well established, their precise mechanisms of antiarrhythmic action remain unclear. Arrhythmias which occur during acute myocardial ischemia can be explained partly on a metabolic basis. The accumulation of intermediates subsequent to impaired β-oxidation of free fatty acids has been suggested as a cause of serious arrhythmias. The purpose of this study was to investigate changes in free carnitine, long chain acyl carnitine and long chain acyl CoA concentrations in the ischemic canine heart following the administration of procainamide and disopyramide. The coronary artery was occluded for 40min and myocardial samples were prepared from both nonischemic and ischemic areas. Procainamide and disopyramide prevented the accumulation of long chain acyl carnitine and long chain acyl CoA in the ischemic myocardium. The results showed that procainamide and disopyramide had beneficial effects on fatty acid metabolism. It was suggested that one of the antiarrhythmic mechanisms of these drugs might be the prevention of the accumulation of fatty acyl derivatives in the isehemic myocardium.

Procainamide

Disopyramide

Antiarrhythmic agent

10.1536/ihj.29.831

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Citations (0)

Disopyramide see Procainamide/quinidine/disopyramide

Reactions Weekly (1990)

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Disopyramide

Procainamide

Quinidine