[Non-Hodgkin lymphomas as a cause of persistent fever in internal medicine wards--a series of cases].
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Patients with a suspicion of non-Hodgkin lymphoma (NHL) represent a diagnostic challenge for clinicians, because they may present with a variety of symptoms. We present a series of 5 patients in whom persistent fever was one of the earliest symptoms of NHL.Cite
Patients with a suspicion of non-Hodgkin lymphoma (NHL) represent a diagnostic challenge for clinicians, because they may present with a variety of symptoms. We present a series of 5 patients in whom persistent fever was one of the earliest symptoms of NHL.
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Introduction. Intensive treatment protocols used for non-Hodgkin lymphoma in children lead to eventfree survival rates ranging from 80% to 90%. However, the results are less successful in developing countries. Lymphoblastic lymphoma (LBL) is the second most frequent type of lymphoma in children, contributing with about one third to all non-Hodgkin lymphoma in childhood. Objective. The aim of the study was to evaluate the results of LBL treatment in University Children?s Hospital (UCH), Belgrade. Methods. A retrospective analysis of patient records at UCH from 1997 to 2015 was carried out in patients aged 0-18 years, in whom the diagnosis of LBL had been established. Twenty-two children were included in the analysis. Results. Mean age at diagnosis was 10 years, with preponderance of male patients. All patients were treated according to Berlin-Frankfurt-M?nster-based chemotherapy protocols. With median follow-up of 91.5 months, five-year probability of event-free survival was 79.5% for all patients, while overall survival was 81.8%. Conclusion. Our results, although slightly inferior to those of leading international groups, reflect a good treatment outcome in our patients.
Single Center
Lymphoblastic lymphoma
Pediatric Oncology
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Immunosuppression
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Background: as the histopathologic diagnosis of Non-Hodgkin Lymphoma (NHL) has become more sophisticated with the use of immunologic and genetic techniques, the understanding and treatment of many of the previously described pathologic subtypes have changed. Aim of the Work: was to review the clinicopathologic characteristics of the NHL patients, to assess the treatment response to the different treatment modalities available at our center and to analyze the correlation between patient's characteristics, treatment modality and the achieved response. Patients and Methods: the current work was a retrospective study reviewing the data of patients with pathologically confirmed diagnosis of low-grade NHL referred to Al Hussein university Hospital, Department of Clinical Oncology, Faculty of Medicine, Al-Azhar University during the period between January 2012 till December 2016. Results: more than half the study group (57.2%) had the age between 41 and 60 years. Only 14.2% of the study group was younger than 40 years and 28.6% were older than 60 years. There was no difference between patients with CLL and patients with Low grade NHL as regards the age distribution. NHL in this study was equal among both males and females in both above 40 and below 40 age groups, unlike what was mentioned before which stated that NHL is more common in males than in females. Conclusion: only 31 patients were evaluable for survival analysis with median follow up period of 15 months. Median disease-free survival (DFS) was 12 months (95% CI 0-72.9).
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Objective To evaluate 18 F-fluorodeoxyglucose (FDG) PET imaging in fever of unknown origin for screening of lymphoma. Methods Fifty-nine patients with fever of unknown origin (fever more than three weeks,temperature over 38.3 ℃) underwent PET imaging with 18 F-FDG,the results were compared with the final diagnosis. Results Eight patients (13.6%) were diagnosed as lymphoma by PET imaging in the fifty-nine cases with fever of unknown origin,which were verified as two Hodgkin lymphoma and six non-Hodgkin lymphoma. Conclusions PET imagings can find the lesions of lymphoma with fever smaller than 1 cm or deep in body. 18 F-FDG PET imaging appears to be a valuable imaging procedure for screening of lymphoma in fever of unknown origin.
PET Imaging
Fluorodeoxyglucose
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Fluorine
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A case report of boutonneuse fever with pulmonary complications in a patient with non-Hodgkin's lymphoma (NHL) is described. The patient was hospitalized for persistent hypertermia and marked dyspnea, with radiographic findings of bilateral involvement of the lungs. The confirmation of the diagnosis was obtained by means of serum analyses (Weil-Felix serodiagnosis and IFA); the patient responded to doxycycline with progressive improvement of her general health condition. In this case the occurrence of a NHL could justify the lower reactivity and the facilitated diffusion of rickettsiosis in the patient.
Boutonneuse fever
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Abstract BackgroundLymphoma is found to be the main source of non-infectious fever of unknown origin (FUO). However, there is a lack of clinical features and outcomes in lymphoma patients initially presenting as FUO.MethodsFrom January 1, 2013 to December 31, 2019, our center enrolled 185 patients who initially presented as FUO then confirmed to be lymphoma in Huadong Hospital of Fudan University. During the same study period, 332 lymphoma patients without FUO received treatment in our center. After the exclusion, 509 patients were included in the retrospectively study. The differences in clinical manifestations, laboratory examinations, overall response rates and survival rates between the FUO and non-FUO groups were analyzed. The clinical endpoints were overall survival (OS) and progress-free survival (PFS).ResultsIn the non-FUO group (329 in total), Hodgkin’s lymphoma (HL) was 17 (5.2%), B cell non-Hodgkin’s lymphoma (B-NHL) was 276 (83.9%), T cell non-Hodgkin’s lymphoma (T-NHL) was 32 (9.7%) and NK/T cell lymphoma (NK/T-CL) was 4 (1.2%). In the FUO group (180 in total), B-NHL was 88 (48.9%), T-NHL was 60 (33.3%), NK/T-CL was 24 (13.3%) and HL was 8 (4.4%). During the hospitalization, the maximum body temperature of the FUO group diagnosed with B-NHL, T-NHL and NK/T-CL was statistically higher than that of the non-FUO group (all P<0.05). Concerning the overall response rates, there was no difference between the FUO and non-FUO groups, whatever the pathological subtype was. The differences in OS between the FUO and non-FUO groups were significant for HL (P=0.006), B-NHL (P=0.007) and T-NHL (P=0.013). No difference in overall survival was observed in the two groups for the subtype of NK/T-CL (P=0.141). In terms of PFS, there was no significant difference between FUO and non-FUO groups for any subtype (all P>0.05).ConclusionWe found that the major subtypes of lymphoma initially presenting as FUO were B-NHL and T-NHL. The main diagnostic biopsy sites were subcutaneous lymphnodes, bone marrow and spleen for lymphoma patients with FUO. Patients with FUO suffered from a higher risk of all-cause death in the long term.
T-Cell Lymphoma
Single Center
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Non-Hodgkin's lymphoma (NHL) accounts for 4% of new cancer cases and 3% of cancer deaths in both men and women [1]. The majority of patients present with painless peripheral lymphadenopathy, though...
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