[Causes of death in patients with cancer of the gastrointestinal tract under combination treatment].

The main source of circulating immunoreactive somatostatin (IRS) seems to be the gastrointestinal tract. We therefore investigated plasma IRS in patients with various gastrointestinal diseases. Mean basal IRS oscillated between 46 and 73 pg/ml. A postprandial rise was observed in all patients and age-matched controls. However, the increment was significantly higher in patients with duodenal ulcer (159 ± 20 pg/ ml), active ulcerative colitis (176 ± 17 pg/ml), and irritable bowel syndrome (194.4 ± 20.4 pg/ml). Patients with duodenal ulcers who underwent vagotomy showed a decreased postprandial increment (107 ± 10 pg/ml) when compared with active duodenal ulcer patients. No difference was demonstrable between controls and individuals with gastric ulcer, and patients with inactive ulcerative colitis. These results suggest that vagal innervation plays a role in postprandial IRS stimulation, whereas gastric hyperacidity, acute lesions of the colonic mucosa, and hypermotility of the gastrointestinal tract are associated with an exaggerated postprandial IRS response. Since somatostatin is known to influence many gastrointestinal functions, these variations in circulating IRS concentrations may be of pathophysiologic importance.

Basal (medicine)

10.3109/00365528708991938

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Citations (26)

The Timing of Best Tumor Response and Patterns of Disease Progression in Non-small Cell Lung Cancer Treated with EGFR TKI

International Journal of Radiation Oncology*Biology*Physics (2019)

Ying Tang Kan Wu Bing Wang Xiao Xu Menghan Zhang

10.1016/j.ijrobp.2019.06.2445

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The Impact of Adjuvant Radiation Therapy in Elderly Patients with ER Positive, Early Stage Breast Cancer

International Journal of Radiation Oncology*Biology*Physics (2018)

G.Q. Yang A.O. Naghavi Amber Orman Roberto Diaz Kamran A. Ahmed

Interquartile range

Breast-conserving surgery

Hormonal Therapy

10.1016/j.ijrobp.2018.07.1640

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Citations (0)

Variations in Serum Copper and Ceruloplasmin Levels in Advanced Gastrointestinal Cancer Treated with Polychemotherapy

Tumori Journal (1979)

A. Scanni M. Tomirotti Luciano Licciardello Ennio Annibali M Biraghi

Serum copper and ceruloplasmin levels (SCL, SCeL) in 57 patients with advanced cancer of the stomach (35 cases) or large intestine (22 cases) treated with polychemotherapy were studies. In gastroenteric cancer, SCL, which are already high in untreated patients, have a tendency to increase further in cases of progression of the disease, while they seem to significantly decrease in cases of remission. SCeL during the trial appeared to be correlated to the clinical evolution of the disease only in the case of stomach cancer. In large intestine cancer, SCeL did not show any significant variation in relation to the normal range. These observations, in particular on the behavior of SCL in the neoplasms of the digestive tract, are in accordance with the results of other studies. The authors are inclined to attach a diagnostic and prognostic value to the variation in SCL and SCeL in gastrointestinal cancer.

Ceruloplasmin

Gastrointestinal cancer

Stomach cancer

10.1177/030089167906500308

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Citations (15)

[Earl diagnosis and prognosis of gastric cancer].

PubMed (1950)

R Boller

Source

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