Variations in Serum Copper and Ceruloplasmin Levels in Advanced Gastrointestinal Cancer Treated with Polychemotherapy
A. ScanniM. TomirottiLuciano LicciardelloEnnio AnnibaliM BiraghiMarinella TrovatoMario FittipaldiPaola AdamoliG Curtarelli
15
Citation
21
Reference
10
Related Paper
Citation Trend
Abstract:
Serum copper and ceruloplasmin levels (SCL, SCeL) in 57 patients with advanced cancer of the stomach (35 cases) or large intestine (22 cases) treated with polychemotherapy were studies. In gastroenteric cancer, SCL, which are already high in untreated patients, have a tendency to increase further in cases of progression of the disease, while they seem to significantly decrease in cases of remission. SCeL during the trial appeared to be correlated to the clinical evolution of the disease only in the case of stomach cancer. In large intestine cancer, SCeL did not show any significant variation in relation to the normal range. These observations, in particular on the behavior of SCL in the neoplasms of the digestive tract, are in accordance with the results of other studies. The authors are inclined to attach a diagnostic and prognostic value to the variation in SCL and SCeL in gastrointestinal cancer.Keywords:
Ceruloplasmin
Gastrointestinal cancer
Stomach cancer
Gastrointestinal cancer
Cite
Citations (33)
The present study was planned to investigate miR-143 expression during stomach cancer. The study explored the relationship between miR-143 expression and clinicopathological characteristics including proliferation, migration and apoptosis of stomach cancer cells. Sixty-three samples from each of stomach cancer tissue and surrounding tissue were obtained. Total RNA was extracted. The expression levels of miR-143 from stomach cancer tissue as well as from surrounding tissue were measured by semi-quantitative PCR. The effects of miR-143 overexpression on the migration of stomach cancer cells were examined by Transwell assay. The effects of miR-143 overexpression on the apoptosis of stomach cancer cells were examined by flow cytometer. The expression level of miR-143 was significantly decreased in stomach cancer tissues in comparison to surrounding tissues (P<0.01). Moreover, the expression of miR-143 related well with the tumor size, TNM stage, lymphatic metastasis and relapse (P<0.01). On the other hand, stomach cancer cell line with overexpression of miR-143, showed significant decline in proliferation rate and migration rate comparison to control cells (P<0.01). However, it showed significant higher in apoptosis rate (P<0.01). The present study concluded that expression of miR-143 is low during stomach cancer. Further, higher expression levels of miR-143 have the ability to decline proliferation and migration of stomach cancer cells. In this manner, the expression level of miR-143 could be used as an important factor to determine the severity of stomach cancer.
Stomach cancer
Cite
Citations (2)
Serum transferrin and ceruloplasmin were determined in 20 healthy subjects, 23 patients with cancer of the gastro-intestinal system (G.I.S) and 22 patients with other types of cancer. Serum transferrin in patients with cancer of the G.I.S. was significantly decreased in comparison to that of healthy subjects (p < 0.05) and to that of other cancer patients (p < 0.005), but no significant difference was found between the values of healthy subjects and those with other types of cancer. Serum ceruloplasmin was significantly increased in patients with cancer of the G.I.S. (p < 0.01) and other types (p < 0.05) in comparison to that of healthy subjects. No significant difference was found between patients with cancer of the G.I.S. and those with other cancer types. In conclusion, transferrin was significantly decreased in the serum of patients with cancer of the G.I.S. while ceruloplasmin was significantly increased in both groups of patients with G.I.S. and other types of cancer.
Ceruloplasmin
Gastrointestinal cancer
Cite
Citations (14)
Stomach cancer
Cite
Citations (0)
Stomach cancer
Cite
Citations (10)
Stomach cancer is believed to be one of the most common cancers that lead to death. In Iraq, stomach cancer occupies the seventh place of cancer occurrence in both sexes and is counted as one of the ten most common cancers. The current study is designed to explore the link between Helicobacter pylori (H.pylori) infection and the development of incidences of stomach cancer. In addition, related age and gender were also studied. Histological examinations of stomach biopsies were performed in suspected people to evaluate stomach cancer occurrences. Of the 40 patients with stomach cancer, the infection of H. pylori was emphasized in 34 (66.66%) with serum IgG/IgM, which reflected a significant frequency for infection of H. pylori in stomach cancer patients. The study also showed that males with H. pylori infection record a higher percentage than female patients with stomach cancer. Moreover, the results revealed that age is also connected to H. pylori infection. Based on the above findings, monitoring infected people with H. pylori might be an excellent strategy to control stomach cancer occurrences. Keywords: Stomach cancer, Infectious diseases, IgG, IgM, H. pylori.
Stomach cancer
Cite
Citations (0)
Objective:To detect methylation in p16 gene in whole blood and tissue of stomach cancer, and to explore its significance for early diagnosis in stomach cancer.Method:44 tissue samples and their corresponding whole blood samples from patients with stomach cancer, 20 tissue samples with gastric ulcer were collected for methylation measurement by PCR technique.Result:Methylated p16 gene was found in 38.6%(17/44)of stomach cancer and in (88.2%)(15/17) whole blood samples, no methylated p16 gene was found in gastric ulcer. Methylated p16 gene promoter in whole blood strongly correlated with tissue of stomach cancer.Conclusion:The measurement of methylated p16 gene should be helpful to early diagnosis in stomach cancer.
Stomach cancer
Human stomach
Cite
Citations (3)
A comparative evaluation of the results of mass gastro-fluorographic screenings with the aid of special-purpose gastrofluorographs and pulmonary fluorographs adapted for stomach examination in lateral position. Although stomach radiograms obtained by use of pulmonary fluorography installations provide less information, the latter prove to be a good substitute in carrying out mass screenings for stomach tumors, when special-purpose gastrofluorographs are not available. Stomach cancer incidence in out-patients with stomach diseases is 7 times that in subjects who have no complaints, and 2-4 times in patients with stomach disturbances unregistered at dispensary clinics.
Stomach cancer
Dispensary
Cite
Citations (0)
Experiments were conducted in order to determine magnesium concentrations in stomach cancer tissue. As a control, non-cancerous stomach tissue of the same patients was used. Mg concentration in blood serum was also tested in all patients undergoing surgical operation. It has been determined that Mg concentration was higher in cancerous stomach tissue than in control tissue. Average Mg concentration in the blood serum of patients with stomach cancer fluctuates near the lower limit of normal. An analysis of the relationship between Mg concentration and the degree of clinical advancement of cancer has shown that Mg concentration in cancerous stomach tissue increases with the clinical stage. The results obtained were statistically significant. They show that there is a relationship between Mg concentration and the development of stomach cancer.
Stomach cancer
Human stomach
Cite
Citations (7)
Radioinduced disturbances and restoration in the secretory function of the stomach and gastrointestinal tract were compared. It was confirmed that changes in the gastrointestinal tract are more pronounced than in the stomach; blood appeared in the gastric juices but did not show up in stomach juices; at various periods the level of fermentation elements was lowered in the gastric juices while pepsin secretion did not change. The restoration time of disturbed Secretion at various sections in the gastrointestinal tract increased as the bond with the central nervous system weakened. (R.V.J.)
Pepsin
Digestive tract
Cite
Citations (0)