[Yeast mitochondria: distinguishing features, and contribution to solving the general problems of bioenergetics. (Review)].
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The data obtained by the author during more than 30 years of studies of yeast energy metabolism at cellular and mitochondrial levels are summarized. The data suggest that tightly coupled yeast mitochondria represent not only a fully functional, but often a preferable model system for studying many problems of bioenergetics.Keywords:
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Abstract Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca 2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease.
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The data obtained by the author during more than 30 years of studies of yeast energy metabolism at cellular and mitochondrial levels are summarized. The data suggest that tightly coupled yeast mitochondria represent not only a fully functional, but often a preferable model system for studying many problems of bioenergetics.
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[Irreversible changes in energy processes in the mitochondria after chronic exposure to detergents].
Chronic inhalational exposure of white rats to a synthetic detergent 'LOTOS' in concentrations 25 and 100 mg/m3 caused liver mitochondria bioenergetics changes from a reversible low energetic shift up to an irreversible mitochondria damage of an organ-structural character. The degree of the damaging effect depended on the duration of exposure and the concentration of the detergent.
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Abstract Pichia pastoris is a methylotrophic yeast of high biotechnological interest. The bioenergetic properties of mitochondria from Pichia pastoris have not yet been determined. We report on a protocol for the isolation of the mitochondria in a state that shows good energy coupling. Analysis of Pichia pastoris growth and bioenergetic properties of the isolated mitochondria reveals that glycerol is the carbon source that yields the best results. Under our growth conditions, mitochondria oxidize external NADH but do not possess an alternative oxidase. Finally, Pichia pastoris mitochondria also lack the nucleotide‐stimulated uncoupling pathway previously identified in Saccharomyces cerevisiae . Copyright © 2006 John Wiley & Sons, Ltd.
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