[Study of the psychotropic action of rotundine alkaloid: changes of the protein fractions of the brain].
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Indole alkaloid
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The traditional Chinese medical plants had been used for many centuries to support the immune system or to fight human infections.Among them, the phytochemicals of many herbs might suggest the possibility of their exploitations to the botany fungicides.In this study, twelve herbs used in the treatment of infectious diseases in traditional Chinese medicine were evaluated for in vitro activity against sixteen microbial plant pathogens.Among them, eleven were plant-pathogenic fungi and five were bacteria.All of the EtOH extracts were tested by the agar dilution technique.From the assessment of the crude extracts, the Coptis chinensis Franch were active against at least two microorganisms, especially to the Valsa mali Miyabe et Yamada.With the isolation and purification of Coptis, we finally obtained two pure antifungal active alkaloids i.e., berberine and palmatine.And their resistances to the Valsa mali Miyabe et Yamada showed that the 50 % effective concentration (EC50) of the berberine reached 9.84 ppm and the EC50 of palmatine was 243 ppm.
Coptis chinensis
Coptis
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Abstract Cyclisierung des Acetamides (III) ‐ zugänglich aus dem Phenethylamin (I) und der Phenylessigsäure (II) ‐ liefert das Isochinolin (IV), aus dem über das Salz (Va)‐HBr das Racemat (Va) gewonnen wird.
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Convulsants
Convulsants
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Tetrandrine, dauricine, daurisoline and neferine are bisbenzylisoquinoline alkaloid derivatives isolated from Chinese traditional medicine and herbs. The cardiovascular pharmacological effects and the mechanism of actions of these compounds were reviewed. Tetrandrine isolated from Stephania tetrandra S Moore possesses antihyper-tensive and antiarrhythmic effects. The antihypertensive effects of tetrandrine have been demonstrated in experi-mental hypertensive animals and in hypertensive patients. Recent studies showed that in addition to its calcium antagonistic effect, tetrandrine interacted with M receptors. Modulation by M receptor is one of the pharmacologi-cal mechanisms of cardiovascular effects of tetrandrine. Dauricine and daurisoloine were isolated from Menispermum dauricum DC. The antiarrhythmic effects of dauricine have been verified in different experimental arrhythmic models and in cardiac arrhythmic patients. Dauricine blocked the cardiac transmembrane Na+,K+ and Ca2+ ion currents. Differing from quinidine and sotalol, which exhibited reverse use-dependent effect, dauricine prolonged APD in a normal use-dependent manner in experimental studies. The antiarrhythmic effect of daurisoline and neferine which is an alkaloid isolated from Nelumbo nucifera Gaertn, and their mechanisms of actions have also been studied. The antiarrhythmic effect of daurisoline is more potent than that of dauricine.
Tetrandrine
Quinidine
Anti-Arrhythmia Agents
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Evodiamine
Intraperitoneal injection
Sinomenine
Anti-inflammatory
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Abstract Adhatoda vasica Nees is a shrub widespread throughout the tropical regions of southeast Asia. It possesses a wide spectrum of medicinal properties including positive effects on inflammatory diseases. The antiinflammatory activity of the methanol extract, the non‐alkaloid fraction, the saponins and the alkaloids was evaluated by the modified hen's egg chorioallantoic membrane test. The alkaloid fraction showed potent activity at a dose of 50 µg/pellet equivalent to that of hydrocortisone while the MeOH extract and the other fractions showed less activity. Copyright © 2001 John Wiley & Sons, Ltd.
Chorioallantoic membrane
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Peganum harmala
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Tetrandrine
Quinidine
Anti-Arrhythmia Agents
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Бұл зерттеужұмысындaКaно моделітурaлы жәнеоғaн қaтыстытолықмәліметберілгенжәнеуниверситетстуденттерінебaғыттaлғaн қолдaнбaлы (кейстік)зерттеужүргізілген.АхметЯссaуи университетініңстуденттеріүшін Кaно моделіқолдaнылғaн, олaрдың жоғaры білімберусaпaсынa қоятынмaңыздытaлaптaры, яғнисaпaлық қaжеттіліктері,олaрдың мaңыздылығытурaлы жәнесaпaлық қaжеттіліктерінеқaтыстыөз университетінқaлaй бaғaлaйтындығытурaлы сұрaқтaр қойылғaн. Осы зерттеудіңмaқсaты АхметЯсaуи университетіндетуризмменеджментіжәнеқaржы бaкaлaвриaт бaғдaрлaмaлaрыныңсaпaсынa қaтыстыстуденттердіңқaжеттіліктерінaнықтaу, студенттердіңқaнaғaттaну, қaнaғaттaнбaу дәрежелерінбелгілеу,білімберусaпaсын aнықтaу мен жетілдіружолдaрын тaлдaу болыптaбылaды. Осы мaқсaтқaжетуүшін, ең aлдыменКaно сaуaлнaмaсы түзіліп,116 студенткеқолдaнылдыжәнебілімберугежәнеоның сaпaсынa қaтыстыстуденттердіңтaлaптaры мен қaжеттіліктерітоптықжұмыстaрaрқылыaнықтaлды. Екіншіден,бұл aнықтaлғaн тaлaптaр мен қaжеттіліктерКaно бaғaлaу кестесіменжіктелді.Осылaйшa, сaпa тaлaптaры төрт сaнaтқa бөлінді:болуытиіс, бір өлшемді,тaртымдыжәнебейтaрaп.Соңындa,қaнaғaттaну мен қaнaғaттaнбaудың мәндеріесептелдіжәнестуденттердіңқaнaғaттaну мен қaнaғaттaнбaу деңгейлерінжоғaрылaту мен төмендетудеосытaлaптaр мен қaжеттіліктердіңрөліaйқын aнықтaлды.Түйінсөздер:сaпa, сaпaлық қaжеттіліктер,білімберусaпaсы, Кaно моделі.
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