A case/control study of hepatitis B virus serologic markers in Senegalese patients suffering from primary hepatocellular carcinoma.
Pierre CoursagetP MaupasA GoudeauChiron JpBrigitte RaynaudJ DruckerFrancis BarinF DenisDiop MarB Diop
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Background and Aims Deletions/mutations in the hepatitis B virus (HBV) pre-S region have been associated with hepatocellular carcinoma (HCC). We aimed to study the evolutionary changes of pre-S mutations prior to HCC development. Methods We studied the HBV pre-S sequences at 1 to 10 years preceding diagnosis of HCC in 74 patients with HBV-related HCC (HCC group). 148 chronic hepatitis B patients matched for sex and age in 2:1 ratio, who had been followed up for at least 3 years without HCC (HCC-free group) were recruited as controls. 56 and 47 patients of HCC and HCC-free groups respectively had serially stored sera for longitudinally examination at 1–3 years, 4–6 years, 7–9 years and ≥10 years prior to the recruitment of the study. Results Compared to the HCC-free group, higher frequencies of pre-S deletions and point mutations (at 11 codons) were observed in the HCC group (p<0.05). Multiple logistic regression analysis showed that pre-S deletions, point mutations at codon 51 and 167 were independent factors associated with HCC. Longitudinal observation showed that pre-S deletions and most of the 11 HCC-associated pre-S point mutations existed at least 10 years before HCC development, and were more prevalent preceding HCC development in patients from HCC groups than HCC-free group. The number of HCC-associated pre-S point mutations increased over time preceding HCC development, and correlated positively with the time to HCC diagnosis (r = 0.220, p = 0.005). Conclusions High prevalence and cumulative evolution of pre-S mutations preceding HCC development suggested a possible carcinogenic role of pre-S mutations and their potential application in HCC risk prediction.
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Abstract Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer mortality worldwide and is a leading cause of death in individuals with chronic hepatitis B virus (HBV) infection. It is uncertain how the presence of other metabolic factors and comorbidities influences HCC risk in HBV. Therefore, we performed a systematic literature review and meta‐analysis to seek evidence for significant associations. MEDLINE, EMBASE and Web of Science databases were searched from 1 January 2000 to 24 June 2020 for studies investigating associations of metabolic factors and comorbidities with HCC risk in individuals with chronic HBV infection, written in English. We extracted data for meta‐analysis and generated pooled effect estimates from a fixed‐effects model. Pooled estimates from a random‐effects model were also generated if significant heterogeneity was present. We identified 40 observational studies reporting on associations of diabetes mellitus (DM), hypertension, dyslipidaemia and obesity with HCC risk. Only DM had a sufficient number of studies for meta‐analysis. DM was associated with >25% increase in hazards of HCC (fixed‐effects hazards ratio [HR] 1.26, 95% confidence interval (CI) 1.20–1.32, random‐effects HR 1.36, 95% CI 1.23–1.49). This association was attenuated towards the null in a sensitivity analysis restricted to studies adjusted for metformin use. In conclusion, in adults with chronic HBV infection, DM is a significant risk factor for HCC, but further investigation of the influence of antidiabetic drug use and glycaemic control on this association is needed. Enhanced screening of individuals with HBV and diabetes may be warranted.
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Background:The most common risk factors for hepatocellular carcinoma (HCC) are hepatitis B (HBV) and C (HCV).Patients with HCV related HCC have biology and outcomes distinct from HBV related HCC.We evaluated whether there is a difference in time from diagnosis to treatment between HCC patients with HBV and HCV. Methods:We conducted a retrospective chart review to identify patients with confirmed HCC, and a known diagnosis of either HBV or HCV at Bellevue Hospital Center between January 2005 and December 2009.Medical records were reviewed for disease and treatment characteristics.Results: Seventy HBV patients and 76 HCV patients were identified.HBV patients were mostly Asian (87%), while the majority of HCV patients were Black and Hispanic (28% and 47%, p<0.0001).At diagnosis, the HBV group presented with larger tumors compared to the HCV group (median 5.3 cm vs. 3.1 cm, p=0.025), and HCV patients were older than HBV patients (median age 61.3 years vs. 50.7 years, p<0.0001).Patients with HBV related HCC received treatment quicker than their HCV counterparts (median 2.1 vs. 3.2 months, p=0.019). Conclusion:Patients with HCV related HCC wait longer for treatment when compared to patients with HBV related HCC in an urban inner-city hospital Efforts to reduce time between outside referral to oncology services may help decrease such disparity.
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Objective To investigate the effect of rs2279776 at the PTPRD and its interactions on hepatitis B virus(HBV)mutations as well as related risk on hepatocellular carcinoma(HCC).Methods A total of 3023 individ-uals,including 1012 healthy controls,990 HCC-free HBV-infected subjects,and 1021 HBV-caused hepatocellular carcinoma patients(HCC)
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Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver.Hepatitis B virus infection is one of the most important etilogical factors of HCC.In this case report, a patient with HCC previously infected and having ongoing immunity against hepatitis B virus will be discussed.
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The seropositivity for hepatitis B surface antigen (HBsAg) was tested in 68 patients with hepatocellular carcinoma (HCC) to assess the association between hepatitis B virus and hepatocellular carcinoma. Of the 68 patients, 44(64.7%) were positive for HBsAg. The highest prevelance rate (76.2%) was found in the 40 - 90 years age group, and the highest incidence of HCC was also found in the same age group. The patients were predominantly males (M:F;2:1). There was, however, no significant difference in the prevalence rates of HbsAG between male and female HCC patients. This study confirms that hepatitis B virus is associated with most cases of HCC in our environment. (Key words:Hepatocellular carcinoma, Hepatitis B virus). Sahel Medical Journal Vol.6(4) 2003: 104-106
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