A Hepatocellular Carcinoma Case in a Patient Who had Immunity to Hepatitis B Virus Earlier
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Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver.Hepatitis B virus infection is one of the most important etilogical factors of HCC.In this case report, a patient with HCC previously infected and having ongoing immunity against hepatitis B virus will be discussed.Keywords:
Hepatitis virus
Hepatitis B
This is a cross-sectional study to determine the prevalence and risk factors for transmission of hepatitis B virus (HBV) infection in the Gezira state of central Sudan prior to the introduction of blood screening and vaccination against HBV.The study was carried out on the population of Um Zukra village in Gezira state of Central Sudan. The village was surveyed on five consecutive days in Dec 2000. Epidemiological characteristics were recorded and participants were interviewed for risk factors of viral hepatitis. Blood samples were then collected and tested for HBsAg and HBcAb.A total of 404 subjects were screened with a mean age of 35 years; 54.9% were females, HBsAg and HBcAb were reactive in 6.9% and 47.5% of the studied population, respectively. Exposure to HBV increased with increasing age. The only significant risk factor for transmission of infection was a history of parenteral antischistosomal therapy.This study shows that prevalence of HBV infection is high in the studied population and it is hoped that introduction of blood screening and vaccination against HBV would decrease the carrier pool in the next few years.
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This paper reviewes some climical cultures about thcctiology, particularities and complications of infant hepatitis syndrome in 12 years in our country. In which, there are variant percentage and variant clinical manifes tations of virus hepatitis, CMV hepatitis and bacteria infection or toxic hepatitis etc.
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Seroprevalence
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OBJECTIVE To know more clearly about the situation of Hepatitis B virus markers in clinical medical workers and take further interventional strategies to protect high risk medical workers.METHODS Hepatitis B virus markers in doctors,nurses and medical checkers who have contacted with patients′ blood,body fluid,or other occupational hazard situation,were detected by of ELISA.RESULTS Among the 587 medical workers detected,311 were with deficiency of active immunity(52.98%),196 were HBV infectors(33.39%).CONCLUSIONS Medical workers are in high risk groups of HBV infection.Medical institutions should attend to their self-protection and encourage them to take HBV vaccine to prevent iatrogenic transmission.
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Isolation
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1999年Primi等在1例感染人类免疫缺陷病毒的静脉毒瘾者血清中分离出一种新的可能导致急、慢性肝炎的单链DNA病毒,并以该患者姓名的首位字母暂时命名为SEN病毒(senvirus,SENV).现就其分子生物学特征、流行病学及其临床意义综述如下。
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The association of hepatitis C virus (HCV) with neoplasia is not completely understood. Hepatitis C virus is hepatolymphotrophic. It is considered an inducing factor of hepatocellular carcinoma (HCC) and is associated with various types of lymphomas. We describe a patient with HCV cirrhosis who developed gastric lymphoma and HCC, and we review the current data and theories about the oncogenesis of HCV.
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Hepatitis A vaccine
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Zusammenfassung: Trotz der Spenderauswahl, des serologischen Screenings der Blutspenden auf anti-HIV-1, anti-HIV-2, anti-HCV und HBsAg, Inaktivierungs-und Eliminierungsverfahren bleibt ein Restrisiko für hämatogen übertragbare Viren bei Plasmapools und den daraus hergestellten Präparaten.Als zusätzliche Screeningmethode zur Erhöhung der Virussicherheit wird inzwischen die Testung der Einzelspende bzw.von Minipools auf HCV-RNA verlangt.In der vorliegenden Arbeit wurden 142 HBsAg, anti-HCVund anti-HI V-11-2 negative Plasmapools, sowie Plasmapräparate (Imrnunglobulinpräparat und F IX Präparat), welche sum Teil aus für HGV-RNA PCR-positiven Ausgangspools hergestellt worden waren, mittels PCR auf das Vorhandensein von HGV-Nukleinsäure untersucht.Alle untersuchten Pools bzw.Plasmapräparate stammten von Spenden zwischen 1994 und 1996, also vor der Einführung der genannten Pflichttestung auf HCV-RNA.HGV-RNA wurde in 117 der 142 Plasmapools (82,4%) amplifiziert.Allerdings war HGV-RNA nur in einer (6,3%) von 16 IgG-Chargen aus für HGV-Nukleinsäure positiven Kryoüberständen nachweisbar.In 2 (6,5%) von 31 unselektierten Immunglobulinpräparaten war eine HGV-Kontamination vorhanden.
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