The effect observation of diltiazem in variant angina
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Abstract:
Objective To investigate the effect of diltiazem in the therapy of variant angina.Methods 50 cases patients with variant angina were randomly divided into diltiazem group and control group,each of 25 cases.On the basis of conventional therapy,control group were treated with lsosorbide mononitrate,diltiazem group were treated with diltiazem.After treatment,compared the clinical effect,pectoris frequency and duration of angina in two groups.Results The total effective rate of two groups all was 100.0%(P0.05).After treatment,pectoris frequency of angina reduced,duration shortened(P0.05).Conclusion Diltiazem in the treatment of variant angina is effective and safe.Keywords:
Stable angina
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Objective To investigate the clinical efficacy of taking diltiazem orally for patients with ischemic cardiomyopathy and angina pectoris.Methods Seventy-two patients with ischemic cardiomyopathy and angina pectoris were randomly divided into two groups.Thirty patients in control group were treated with normal ways and means,42 patients in diltiazem group were given diltiazem 15-30 mg orally every 6 hours for two weeks,on the basis of normal treatment.The symptom,electrocardiogram,heart rate,blood pressure and heart function were observed in two groups.Results The clinical total effective rate was higher in diltiazem group than that in control group(P0.05).There was no obvious difference in blood pressure and heart function between the two groups(P0.05).The heart rate in diltiazem group was lower than that in control group(P0.05).Conclusion Taking diltiazem orally for patients with ischemic cardiomyopathy and angina pectoris is effective.
Ischemic Cardiomyopathy
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Objective
To study the effect of metoprolol combining diltiazem for patients with coronary heart disease with unstable angina pectoris.
Methods
78 patients with coronary heart disease with unstable angina pectoris treated at our hospital were selected and randomly divided into a control group and an observation group, 39 cases for each group. The control group were treated with metoprolol and the observation group metoprolol and diltiazem. The clinical efficacies were compared between these two groups. The cardiac function [left ventricular ejection fraction (LVEF)] in both groups was measured before and after treatment.
Results
The total effective rate was 94.87% in the observation group and was 76.92% in the control group, with a statistical difference (χ2=5.186, P<0.05). After treatment, the LVEF was higher in the observation group than in the control group, with a statistical difference (P<0.05).
Conclusions
Metoprolol combining diltiazem for patients with coronary heart disease with unstable angina pectoris can improve the patients’ cardiac function and is clinically and significantly effective.
Key words:
Diltiazem; Metoprolol; Coronary heart disease with unstable angina pectoris
Unstable angina
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Objective: To investigate the curative effect of metoprolol compared with diltiazem in the patients with unstable angina pectoris.Methods:The 44 patients with unstable angina pectoris were randomly divided into two groups.The metoprolol group was given 6.25mg metoprolol,2 times/d.The diltiazem group was given 30mg diltiazem,3 times/d.The treatment course was a month.Results:The pain relief,pain recurrence and decrease in acute myocardial infarction in metoprolol group were more than those of diltiazem group(P0.05).Conclusion:Minidose metoprolol can improve symptoms and decreases myocardium infarction.
Unstable angina
Metoprolol Tartrate
Stable angina
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In a double blind 7-week randomized study the authors compared in 29 patients with stable angina the action of placebo, nifedipine and diltiazem. Nifedipine was administered in amounts of 60 mg/day for three weeks, diltiazem 270 mg/day also for three weeks. Nifedipine and diltiazem exerted a significant antianginous action in patients with occluded but collateralized coronary arteries (group A), as well as in patients without collaterals (group B). In both these groups diltiazem improved the load tolerance significantly more than nifedipine. Nifedipine and diltiazem were useful also in patients with mild (group E), medium (group D) and severe (group C) affections of the coronary arteries. Groups C and E differed significantly as to the different effect of nifedipine and diltiazem on load S-T depressions (in group C diltiazem was significantly more effective, in group E nifedipine was insignificantly better), and it was not possible to explain these differences by a different effect on Robinson's index. The authors conclude that neither nifedipine nor diltiazem led in the amounts used to the "steal phenomenon" with clinical impact. In patients with mild affections of the coronary arteries their antiischaemic and antianginous action was similar, in patients with severe affection of the coronary arteries diltiazem was more effective.
Coronary arteries
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Objective To observe the clinic effect and safety of diltiazem combined trimetazidine in the treatment of unstable angina.Methods Forty six cases of unstable angina were randomly divided into two groups: control group and treatment group.The control group was given conventional nitrates,β-blockers,aspirin,clopidogrel and simvastatin;on the basis of these,treatment group was additionally given diltiazem and trimetazidine.The numbers of angina attacking,duration,ECG,blood pressure and heart rates were compared between the two groups.Results Compared with the control group,in the diltiazem combined trimetazidine treatment group,the number of angina attacking reduced,duration shortened(P0.05),ECG dropped significantly(P0.05);heart rates of both groups reduced,blood pressure dropped than that before the treatment(P0.05);after treatment,the heart rates,blood pressure was no significant difference between the two groups(P0.05).Conclusion Diltiazem combined trimetazidine has a good clinical efficacy and high safety in treatment of unstable angina.It is worthy of clinical application.
Trimetazidine
Unstable angina
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Objective: To investigate the clinical effects of diltiazem treatment on unstable angina.Methods: 120 patients diagnosed with unstable angina during January 2010 and May 2011 were randomly divided into two groups: control group were treated with nitroglycerin,and the experimental group were treated with diltiazem.Compare the therapeutic effect between the two groups.Results: The total effective rate of patients was 93.33%(56/60) in the experimental group,but 78.33%(47/60) in the control group.The experimental group showed a better effect than control group,P0.05.Conclusion: Diltiazem treatment had a good effect on unstable angina,so it is worth of clinical application.
Unstable angina
Clinical efficacy
Stable angina
Therapeutic effect
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Objective To investigate the effect and safety of diltiazem associated with metoprolol in treating mixed angina pectoris . Methods 31patients with mixed angina pectoris who had been treated with aspirin , nitrate and metoprolol for two weeks but unable to get better, were given diltiazem for another two weeks. The frequencies and degree of angina pectoris ,ECG and cardiac functions before and after diltiazem given were contrasted in the patients.Results (1) The onest frequecy and the duration of angina after diltiazem given were significantly decreased .(2) The apparent improvement of ischemic ST-Ts were observed. (3) There weren't change of cardiac functions in the patients before and after diltiazem given . (4) Sinus bradycardia occured in two patients after diltiazem given ,and then recovered by making adjustment of dosages of diltiazem .Conclusion Diltiazem associated with metoprolol for the patients with mixed angina pectoris is effective and safe.
Stable angina
Sinus bradycardia
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Bepridil
Unstable angina
Tolerability
ST depression
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A randomized blind cross-over study with placebo lead-in compared efficacy of calcium antagonists diltiazem and verapamil in 71 patients with stable angina concurrent with arterial hypotension (group 1) and 38 normotensive patients with ischemic heart disease (group 2). By acute bicycle exercise test evidence, verapamil was effective in 80% and 82% patients of group 1 and 2, respectively, dilitiazem--in 67 and 77%, respectively. Cumulation of the effect (p < 0.01) to the third month of verapamil course was comparable in both groups. Tolerance to an antianginal effect of dilitazem developed in 53% patients of group 1 (against 30% in group 2, p < 001) in 2-4 weeks of therapy (against 4-12 weeks in group 2, p < 0.05). By stress 199-T1 scintigraphy of the myocardium, administration of effective doses of diltiazem reduced the number of hypoperfused segments by at least 30%.
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The authors compared by means of bicycle ergometry the effect of a single dose of 90 mg diltiazem (Dilzem Gödecke Co.) and placebo in 31 patients with chronic stable angina pectoris grade II-III according to NYHA. These patients were divided into group A where the pathomorphology of the coronary circulation made the "steal phenomenon" possible and group B where there were no conditions for the "steal phenomenon". Diltiazem, as compared with placebo, increased significantly in both groups the total work output during ergometric examination, delayed significantly the onset of stenocardia and the time before the development of a 1 mm depression of the ST segment; in group A it significantly reduced the depression of the ST segment during the maximum equal load achieved with diltiazem and placebo; it significantly reduced the diastolic blood pressure at rest and during exercise, it significantly reduced the heart rate in group B during exercise. The differences in the action of diltiazem, as compared with placebo, between the two compared groups A and B were not significant in any of the investigated parameters. Administration of diltiazem had a very favourable anti-anginal and anti-ischaemic action in both groups of patients, regardless of the morphology of the coronary affection.
ST depression
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