Metoprolol combining diltiazem for patients with coronary heart disease with unstable angina pectoris
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Abstract:
Objective
To study the effect of metoprolol combining diltiazem for patients with coronary heart disease with unstable angina pectoris.
Methods
78 patients with coronary heart disease with unstable angina pectoris treated at our hospital were selected and randomly divided into a control group and an observation group, 39 cases for each group. The control group were treated with metoprolol and the observation group metoprolol and diltiazem. The clinical efficacies were compared between these two groups. The cardiac function [left ventricular ejection fraction (LVEF)] in both groups was measured before and after treatment.
Results
The total effective rate was 94.87% in the observation group and was 76.92% in the control group, with a statistical difference (χ2=5.186, P<0.05). After treatment, the LVEF was higher in the observation group than in the control group, with a statistical difference (P<0.05).
Conclusions
Metoprolol combining diltiazem for patients with coronary heart disease with unstable angina pectoris can improve the patients’ cardiac function and is clinically and significantly effective.
Key words:
Diltiazem; Metoprolol; Coronary heart disease with unstable angina pectorisKeywords:
Unstable angina
Objective To investigate the clinical efficacy of taking diltiazem orally for patients with ischemic cardiomyopathy and angina pectoris.Methods Seventy-two patients with ischemic cardiomyopathy and angina pectoris were randomly divided into two groups.Thirty patients in control group were treated with normal ways and means,42 patients in diltiazem group were given diltiazem 15-30 mg orally every 6 hours for two weeks,on the basis of normal treatment.The symptom,electrocardiogram,heart rate,blood pressure and heart function were observed in two groups.Results The clinical total effective rate was higher in diltiazem group than that in control group(P0.05).There was no obvious difference in blood pressure and heart function between the two groups(P0.05).The heart rate in diltiazem group was lower than that in control group(P0.05).Conclusion Taking diltiazem orally for patients with ischemic cardiomyopathy and angina pectoris is effective.
Ischemic Cardiomyopathy
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【Objective】To investigate the clinical efficacy and safety of diltiazem in pulmonary heart disease patients with unstable angina pectoris.【Methods】207 pulmonary heart disease patients with unstable angina pectoris were studied and randomly divided into the control group and observed group.The control group were given nitroglycerin while the observed group were given diltiazem.The changes of angina symptom,electrocardiogram(ECG) and hemodynamics were observed.【Results】Angina symptoms were remarkably relieved after the bolus diltiazem in the observed group,and the onset frequency of angina and the longest duration peronset after administration of diltiazem were significantly decreased.Abnormal S-T segments on ECG obviously improved in the observed group.Heart rate(HR) and blood pressure(BP) were significantly decreased.【Conclusion】Diltiazem therapy is effective and safe for pulmonary heart disease patients with unstable angina pectoris.
Unstable angina
Bolus (digestion)
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Objective: To investigate the curative effect of metoprolol compared with diltiazem in the patients with unstable angina pectoris.Methods:The 44 patients with unstable angina pectoris were randomly divided into two groups.The metoprolol group was given 6.25mg metoprolol,2 times/d.The diltiazem group was given 30mg diltiazem,3 times/d.The treatment course was a month.Results:The pain relief,pain recurrence and decrease in acute myocardial infarction in metoprolol group were more than those of diltiazem group(P0.05).Conclusion:Minidose metoprolol can improve symptoms and decreases myocardium infarction.
Unstable angina
Metoprolol Tartrate
Stable angina
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Objective: To study the curative effect of Suxiaojiuxin Pills(Rhizoma Chuaoxiong, Borneolum Syntheticum) in treating coronary heart disease and following angina pectoris. Methods: 70 patients were divided into two groups at random: the treatment group with 40 cases and the control group with 30 cases. The treatment group was given drug Suxiaojiuxin Pill 5 pills tid and the control group was given drug Xiaoxintong 10mg tid orally. The treating period was 4 weeks. Angina pectoris was observed and electrocardiogram determined before and after treatment. Results: Both drugs showed a clinical effect on angina pectoris. The total effective rate was 92.5% in treatment group and 90.0% in control group( P 0.05). The total effective rate in improving electrocardiogram was higher in treatment group(57.5%) than in control group(30.0%).( P 0.05) Conclusion: Suxiaojiujin Pills is effective for coronary heart disease and following angina pectoris.
Pill
Drug treatment
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Objective To investigate the effect of diltiazem in the therapy of variant angina.Methods 50 cases patients with variant angina were randomly divided into diltiazem group and control group,each of 25 cases.On the basis of conventional therapy,control group were treated with lsosorbide mononitrate,diltiazem group were treated with diltiazem.After treatment,compared the clinical effect,pectoris frequency and duration of angina in two groups.Results The total effective rate of two groups all was 100.0%(P0.05).After treatment,pectoris frequency of angina reduced,duration shortened(P0.05).Conclusion Diltiazem in the treatment of variant angina is effective and safe.
Stable angina
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OBJECTIVE To investigate the clinical therapeutic effect of nicorandil for the patients with unstable angina pectoris.METHODS 90 cases with unstable angina pectoris were chosen and randomly divided into experiment group and control group.The control group were treated with dual antiplatelet,nitrates,beta blockers,ACEI,low molecular weight heparin and the other statins.The experiment group were treated with dosages for controls and additionally with 5mg of nicorndil(3times a day)for 2 weeks.The angina pectoris attack,electrocardiogram periodic inspection and adverse reactions were observed and analyzed.RESULTS The total efficiency was 93.3% in the observation group and 75.6% in the control group,which were significantly different between the two groups(P﹤0.05).CONCLUSION Nicorndil can significantly improve the clinical symptoms,signs and clinical therapeutic effect of the patients with unstable angina pectoris.
Nicorandil
Unstable angina
Dose
Therapeutic effect
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Objective To observe the clinic effect and safety of diltiazem combined trimetazidine in the treatment of unstable angina.Methods Forty six cases of unstable angina were randomly divided into two groups: control group and treatment group.The control group was given conventional nitrates,β-blockers,aspirin,clopidogrel and simvastatin;on the basis of these,treatment group was additionally given diltiazem and trimetazidine.The numbers of angina attacking,duration,ECG,blood pressure and heart rates were compared between the two groups.Results Compared with the control group,in the diltiazem combined trimetazidine treatment group,the number of angina attacking reduced,duration shortened(P0.05),ECG dropped significantly(P0.05);heart rates of both groups reduced,blood pressure dropped than that before the treatment(P0.05);after treatment,the heart rates,blood pressure was no significant difference between the two groups(P0.05).Conclusion Diltiazem combined trimetazidine has a good clinical efficacy and high safety in treatment of unstable angina.It is worthy of clinical application.
Trimetazidine
Unstable angina
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Objective: To investigate the clinical effects of diltiazem treatment on unstable angina.Methods: 120 patients diagnosed with unstable angina during January 2010 and May 2011 were randomly divided into two groups: control group were treated with nitroglycerin,and the experimental group were treated with diltiazem.Compare the therapeutic effect between the two groups.Results: The total effective rate of patients was 93.33%(56/60) in the experimental group,but 78.33%(47/60) in the control group.The experimental group showed a better effect than control group,P0.05.Conclusion: Diltiazem treatment had a good effect on unstable angina,so it is worth of clinical application.
Unstable angina
Clinical efficacy
Stable angina
Therapeutic effect
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Objective:To investigate the effect of metoprolol compared with diltiazem in patients with myocardium Infarction repeatedly.Methods:The 44 patients with repeated myocardium infarction randomly divided into two groups.The metoprolol group applies 6.25mg metoprolol,2 timesd.The diltiazem group applies 30mg diltiazem,3 timesd.Course of treatment was a month all.Results:There was no significant difference between two groups about the death rate of short-term(P0.05).The symptomatic relief of pain and pain recur attack,heart failure decrease in metoprolol group were more than those of diltiazem group(P0.05 all).Conclusion:Minidose metoprolol can improve symptoms and decreases heart failure.
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OBJECTIVE:Investigate the clinical efficacy and side effcets of domestic for Liqihuayuwan to coronary,heart disease angina pectoris.METHOD:110 angina pectoris patients were divided into two groups at random:investigated group and treated group.Treated group was given Ligihuayuwan by po,investigated group of stable angina pectoris was given ISOSorbide Dinitrate by po,instable angina pectoris was given ISOSorbide Dinitrate and Isoptin,treatment times were 15days.RESULTS: efficacy of treated group and investigated group were 94.55% and 72.73%;the difference was significunt,treatment time in the treated group was shorter than that in the investigated group and there were no clnical side effcets in the treated group.CONCLUSION:Ligihuayuwan has singificant effcets in treatment of coronary heart disease angina pectoris and has no side effects of domestic.
Isosorbide dinitrate
Stable angina
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