Effect of metoprolol compared with diltiazem in patients with myocardium infarction repeatedly
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Objective:To investigate the effect of metoprolol compared with diltiazem in patients with myocardium Infarction repeatedly.Methods:The 44 patients with repeated myocardium infarction randomly divided into two groups.The metoprolol group applies 6.25mg metoprolol,2 timesd.The diltiazem group applies 30mg diltiazem,3 timesd.Course of treatment was a month all.Results:There was no significant difference between two groups about the death rate of short-term(P0.05).The symptomatic relief of pain and pain recur attack,heart failure decrease in metoprolol group were more than those of diltiazem group(P0.05 all).Conclusion:Minidose metoprolol can improve symptoms and decreases heart failure.Cite
Objective:To observe the efficacy and safety of intravenous metoprolol and diltiazem for control of ventricular rate in patients with atrial fibrillation.Methods:A total of 105 patients with atrial fibrillation were randomized to 3 groups:metoprolol group(n=39):treated with injected metoprolol.Diltiazem group (n=35):treated deltiazem injected;Cedilanid group (n=31):treated with cedilanid injected.Electrocardiogram and blood pressure recordings were performed before and after drug administration. The efficiencies at different time points were compared.Results:Compared with the cedilanid group, metoprolol and diltiazem took faster effect[(36.9±11.6)min∶( 8.2±4.5)min∶(9.1±3.8)min,P0.05],the ventricular rate mort decreased(P0.05),and had a higher total effective rate (71.0%∶89.7%∶91.4%, P0.05).There was no diversity between metoprolol group and diltiazem group.There was not any severe side effect in three groups.Conclusion:To control ventricular rate of rapid atrial fibrillation by intravenous metoprolol and diltiazem is rapid,safe and efficacious.
Ventricular rate
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Objective:To evaluate the effect of Metoprolol on ventricular tachycardia storm secondary to acute coronary syndrome.Method:Sixty-four patients with ventricular tachycardia storm secondary to acute coronary syndrome from May 2006 to December 2008 were randomly divided into two groups:control group and Metoprolol intervention group.Patients in control group were treated with Lidocaine or Amiodarone and electric cardiover-sion,while patients in Metoprolol intervention group were intravenously administrated with Metoprolol injection on the basis of the treatment of control group.Result:The success rate of terminating repeated ventricular tachy-cardia or ventricular fibrillation of Metoprolol intervention group was significantly higher than that of control group (91.2%vs 30.0%,P0.05).The necessary discharge times of terminating ventricular tachycardia or ventricular fibrillation in Metoprolol intervention group was considerably decreased than those in control group([4.19±3.27] vs[8.48±5.12]min,P0.05).The incidence of atrioventricular block in Metoprolol intervention group was markedly increased compared with that in control group(20.6%vs 6.7%,P0.05).No significant difference was found in the incidence of hypotension(41.2%vs 33.3%,P0.05).Conclusion:It is important to be aware of the existence of ventricular tachycardia storm secondary to acute coronary syndrome.On the basis of conventional treatment,intravenous administration of Metoprolol injection is a safe and effective therapy to ventricular tachycardia storm.
Atrioventricular block
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Objective To study or evaluate the therapeutic effect and security of captopril combined with metoprolol treating chronic heart failure.MethodA total of 90 patients with coronary atherosclerotic heart disease accompanied with mild/midrange heart failure were chosen and divided into 3 groups randomly,including patients treated with metoprolol combinated with captopril(30 cases),patients treated with metoprolol only(30 cases),patients treated with captopril only(30 cases).Basing on the standard amount of drug consumption,the administration of metoprolol and captopril was begined with small dose and then increased to target dose.UCG was examined for 3 times within 8 months to evaluate left ventricular end diastolic volume.ResultsAfter the treatment,LVEF increased,LVESV and LVEDV decreased in three groups.Comparing with the group treated with metoprolol only and the group treated with captopril only,there were significant differences in the group treated with metoprolol combined with captopril(P0.05).24 case(80%) in the group treated with metoprolol combined with captopril reached tolerant target dose and its common side effect was dizziness.Comparing with other two groups,there were no obvious differences.No damage of livers and kidneys and no changes of hemogram,electrolyte or glycometabolism were found.ConclusionsBased on the standard amount of drug consumption,metoprolol combined with captopril is safe and effective to mild or midrange CHF and can improve the reshaping of left ventricle.
Captopril
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Objective To explore the clinical value of application of metoprolol and nifedipine in the treatment of asymptomatic myocardial ischemia for the elderly.Methods 56 cases of elderly patients with silent myocardial ischemia were chosen.They were randomly divideded into the metoprolol group of 28 cases and nifedipine group with 28 cases according to the number table.The incidence of complications during treatment in the metoprolol and nifedipine group were analyzed.The seizure frequency and onset time in the two groups of patients were compared before and after treatment.Results The onset time in the two groups,before treatment had no statistically significant difference[the number of attacks:(19.6±3.2) times/week compared with(18.9±2.8) times/week;attack time:(5131±352)s vs (5130 ± 348 ) s,all ( P ＞ 0.05 ).After treatment,there were statistically significant differences for the number of attacks and attack time [the number of attacks:(4.6 ± 2.1 ) times/week compared with ( 7.4 ± 2.1 )times/week,onset tine:(900 ± 140) s vs ( 1440 ± 240 ) s ( all P ＜ 0.05 ).All patients can tolerate the treatment period,there was no cases of myocardial infarction occurs.Conclusion The metoprolol and nifedipine for the elderly treatment of silent myocardial ischemia was more secure,and metoprolol was more effective than nifedipine.
Key words:
Metoprolol; Nifedipine treatment ; Silent myocardial ischemia
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Objective To investigate the effects of metoprolol and diltiazem on patients with cardiac X-syndrome.Methods Forty-two patients with cardiac X-syndrome were randommized to receive metoprolol(20 cases)and diltiazem(22 cases).The clinical presentations,results of treadmill tests and coronary flow reserve(CFR)after 3 months of treatment were compared between the two groups.Results After 3 months therapy,the duration of treadmill was significantly increased.The number of patients with chest pain was significantly decreased.Compared with diltiazem group,the duration of treadmill of metoprolol group was much longer.The coronary flow reserve was lower in diltiazem group than that in metoprolol group.Conclusion Metoprolol may have a better effect than Diltiazem in the improvement of exercise tolerance for the patients with cardiac X-syndrome.
Treadmill
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Objective To observe enalapril combined with metoprolol in the treatment of chronic heart failure(CHF).Methods In our hospital 120 cases of chronic heart failure patients were randomly divided into study group and control group.Study group on the basis of conventional therapy,with oral enalapril and metoprolol treatment,treatment for7d.Control group on the basis of conventional therapy,given metoprolol treatment.Results The total effect rate of study group was 93.3%,and the control group was 63.3%;the difference was statistically significant(P0.05).Left ventricular ejection fraction after treatment(LVEF),left ventricular end-diastolic diameter(LVDP)before treatment significantly improved(P0.05).Conclusion Enalapril treatment of chronic heart failure metoprolol exact effect,can improve heart function,improve patient quality of life.
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Objective:To study the therapeutic effect of metoprolol in patients with chronic congestive heart failure.Methods:A total of 72 patients with congestive heart failure(CHF)were randomly divided into routine therapy group(control group,34 cases,treated with routine therapy)and metoprolol group(38 cases,treated with metoprolol above the base of therapy in control group).The metoprolol start dose was 0.25mg,increased dose every two weeks,until 50mg,two timesd and continued three months in metoprolol group.Results:The excellence rate was 44.7%,and the total effective rate was 89.4% in metoprolol group,its were more than those of control group(26.5%,64.7%,P0.05).The heart rate,blood pressure,left ventricular ejection fraction(LFEF)and left ventricular end-diastolic dimension(LVEDD)significantly improved after therapy in metoprolol group,the improve of heart rate,blood pressure and LVEF were more than those of control group(P0.05).Conclusion:Therapeutic of metoprolol above the routine therapy is effective and safety,may improve cardiac ventricular remodeling.
Therapeutic effect
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Objective To investigate the clinical significance of acute myocardial infarction by early intravenous metoprolol,and to investigating the proper use.Methods 130 acute myocardial infarction patients were randomly divided into the metoprolol group and control group,each group of 65 cases,the control group were treated by the routine treatment,metoprolol group were treated oral metoprolol tablet,25mg/times,2 times/day,continuous treatment for 2 months.Results The ventricular arrhythmias,heart rate≤60 beats/min,cardiogenic shock,death,angina relieved of metoprolol group were better than the control group,P0.01;the average heart rate,CK-MB values,CK-MB peak time,duration of chest pain,ECG ST segment time,ST-segment elevation duration,EF values of metoprolol group and the control group were better than the control group,the difference was statistically significant,P0.01.Conclusion Early use of metoprolol were given in acute myocardial infarction patients have important clinical significance,can significantly reduce myocardial infarct size,correct cardiac remodeling,reduce ischemia caused by chest pain,reduce total mortality and sudden cardiac death,improve prognosis,have no significant adverse reactions,tolerance is good,worthy of clinical application,according to the patient's condition,the flexibility to use different dosing regimens.
Clinical Significance
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Objective To investigate the curative effect of fosinopril and metoprolol for the treatment of chronic heart failure(CHF).Methods Sixty-four patients with CHF patients were randomly divided into the treatment group and the control group.The patients in control group were treated with conventional drugs(diuretics,vasodilator drug,digitalis),while the patients in treatment group were treated with fosinopril and metoprolol for 48 weeks on the basis of conventional medication.Clinical effect,electrocardiographic changes and echocardiography heart function indexes were observed.Results The clinical effect and electrocardiographic changes were better in treatment group than these in control group(P0.05).Compared with control group,the left ventricular end-systolic dimension was shorter(P0.05),left ventricular ejection fraction was higher in treatment group(P0.05).Conclusion The curative effect of fosinopril and metoprolol in treatment of CHF is obvious.
Fosinopril
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Comparison of atenolol with metoprolol in the treatment of patients with acute myocardial infarction
Objective To compare the therapeutic effect with safety of atenolol and metoprolol in the treatment of patients with acute myocardial infarction.Methods Forty-eight patients with acute myocardial infarction were randomly divided into two groups,atenolol group(n=24) and metoprolol group(n=24),receiving 5 to 10 mg of intravenous atenolol and metoprolol respectively.Blood pressure and heart rate were observed 5 minutes after drug administration and ST segment change and cardiac enzymes were measured 24 hours after drug administration.Results There were no significant differences between the two groups in the reduction of blood pressure and heart rate,ST segment regression and reduction of cardiac enzyme(P0.05).Conclusion Atenolol is similar to metoprolol in therapeutic effect and safety in the treatment of the patients with acute myocardial infarction.
Atenolol
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