Study on the relationship between plasma level of brain natriuretic peptide and the cardiac function in the patients with chronic heart failure
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Abstract:
Objective To study the relationship between level of brain natriuretic peptide and the cardiac function in the patients with chronic heart failure and to investigate the value of brain natriuretic peptide in the diagnosis and illness evaluation on chronic heart failure.Methods The plasma brain natriuretic peptide level of 134 chronic heart failure patients and 102 controls were measured with ELISA method.Left ventricular ejection fraction and cardiac index were detected with color Doppler.Correlation analysis was done between plasma level of brain natriuretic peptide and left ventricular ejection fraction,cardiac index in chronic heart failure patients.Results The plasma brain natriuretic peptide level in chronic heart failure group was much higher than that in the controls(P0.01),which was positively correlated with NYHA class,and negatively with left ventricular ejection fraction and cardiac index.After regular treatment,with the improving of heart function,the level of brain natriuretic peptide declined obviously(P0.05).Brain natriuretic peptide level in the patients without improved heart function was significantly higher than that in the patients with improved heart function(P0.01).Conclusion The plasma level of brain natriuretic peptide is correlated with the cardiac function in patients with chronic heart failure,and it has some clinical value in the diagnosis and evaluation of the condition on the patients with chronic heart failure.Keywords:
Brain natriuretic peptide
Cardiac index
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Objective
To explore the value of plasma brain natriuretic peptide test in the diagnosis and treatment of elderly heart failure patients with normal ejection fraction, and to provide reference for clinical diagnosis and treatment of the disease.
Methods
104 patients with heart failure were selected,at the same time, 30 elderly patients with normal heart function in our hospital were selected as the control group. The plasma brain natriuretic peptide and cardiac color Doppler ultrasound were examined. The plasma brain natriuretic peptide and left ventricular ejection fraction, left ventricular posterior wall thickness, left ventricular mass index, left ventricular diastolic diameter and ventricular septal thickness were compared between two groups;at the same time, peptide and left ventricular plasma brain natriuretic ejection fraction were compared in heart failure patients with different levels of NYHA.
Results
The plasma level of brain natriuretic peptide, left ventricular posterior wall thickness, left ventricular mass index in the heart failure group were(401.37±368.63)ng/L, (13.42±1.33)mm,(130.62±9.18)g/m2, which were significantly higher than those of the control group(all P < 0.05). The left ventricular ejection fraction of the heart failure group was(51.36±4.41)%,which was significantly lower than the control group(P< 0.05).The left ventricular ejection fraction of patients with different NYHA grading in the heart failure group was significantly lower than that of the control group(all P< 0.05), plasma brain natriuretic peptide levels in patients with different NYHA grading were significantly higher than those in the control group,and with the elevated levels of NYHA classification,the plasma brain natriuretic peptide level increased significantly(P< 0.05).
Conclusion
The level of plasma brain natriuretic peptide in elderly heart failure patients with normal ejection fraction was significantly increased,and with the increase of NYHA grade, plasma brain natriuretic peptide level rised, it is important to assess diagnosis and severity of this disease.
Key words:
Plasma brain natriuretic peptide; Heart failure in the elderly; Ejection fraction
Brain natriuretic peptide
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The levels and pathophysiological role of amino terminal C-type natriuretic peptide in heart failure are unknown. The potential of plasma amino-terminal C-type natriuretic peptide (N-CNP) as a marker of cardiac function was investigated in symptomatic patients. In 305 patients with recent-onset dyspnea and/or peripheral edema, presenting to primary care, assay of plasma amino-terminal C-type natriuretic peptide and other plasma vasoactive hormones was conducted together with echocardiography. Heart failure was diagnosed in 77 (of the 305) patients by rigorous application of predefined criteria. Plasma amino-terminal C-type natriuretic peptide concentrations were elevated in patients with heart failure, and by univariate analysis were related to age, renal function, and other hormones. On multivariate analysis, tertile of plasma N-CNP interacted with tertile of plasma amino-terminal B-type natriuretic peptide to predict heart failure independent of age, gender, renal function, or echocardiographic left ventricular fractional shortening. N-CNP showed significant relations to concurrent plasma CNP, atrial natriuretic peptide (ANP), N-ANP, B-type (or brain) natriuretic peptide (BNP), N-BNP, endothelin-1, and adrenomedullin but not to echocardiographic indicators of left ventricular systolic function. Plasma amino-terminal C-type natriuretic peptide is elevated in heart failure and is related to other plasma hormones in heart failure. These findings suggest a possible compensatory response from the peripheral vasculature to heart failure by an endothelium-based vasodilator peptide and mandate further exploration of the role of C-type natriuretic peptide in this condition.
Atrial natriuretic peptide
Brain natriuretic peptide
NPR2
Adrenomedullin
Urotensin II
Nesiritide
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Objective To study the correlations between plasma concentrations of N-terminal pro brain natriuretic peptide (NT-proBNP) with cardiac function in patients with chronic heart failure.Methods Plasma NT-proBNP levels of patients with cardiac diseases (n=120) and of normal controls (n=34) were measured by enzyme-linked immunoassay.Results The plasma NT-proBNP concentrations of patients with chronic heart failure were significantly higher than those of the normal controls and the cases with non heart failure respectively. They also increased with the severity of cardiac failure according to NYHA functional classification (P0.001).Conclusion The plasma NT-proBNP concentration is a important biochemical parameter for evaluating heart function.
Brain natriuretic peptide
Plasma levels
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Objective To investigate the detection value of plasma brain natriuretic peptide(BNP) in patients with heart failure.Methods 90 patients with heart failure were selected as subjects of this experiment.These include left ventricular failure,left ventricular diastolic failure and normal cardiac function.The same period 100 cases of healthy people were selected as control group.Compared four groups of patients with plasma BNP.Results plasma BNP of Heart failure patients was higher than the healthy group( P ＜ 0.05 ).The level of the serum BNP of failure patients with left ventricular systolic function was higher than those of other heart failure patients ( all P ＜ 0.05 ).Conclusion Patientswith heart failure plasma BNP to aid medical diagnosis,it has high clinical value.
Key words:
Heart failure; Brain natriuretic peptide
Brain natriuretic peptide
Diastolic heart failure
Plasma levels
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Objective To observe the clinical changes of plasma brain natriuretic peptide level in patients with acute left heart insufficiency.Method Immunohistochemical analysis method was applied to detect the plasma brain natriuretic peptide level in 30 cases at left heart insufficiency onset and remission after onset,and compared with the control group.Results The plasma brain natriuretic peptide levels increased significantly when the onset of acute left heart insufficiency(P0.001).Conclusion The onset of acute left heart insufficiency has sharply increased levels of plasma brain natriuretic peptide,plasma brain natriuretic peptide level increasing is a clinical indicator for the heart failure.
Brain natriuretic peptide
Atrial natriuretic peptide
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Objective To investigate the value of plasma brain natriuretic peptide level in diagnosis of heart failure and its significance in assessing cardiac function.Methods One hundred and thirteen patients with heart failure as heart failure group,and 100 healthy persons as control group were selected to determine the plasma BNP level by the rapid fluorescent dry quantitative analyzer and immunofluorescence method.Then the heart failure patients was graded according to the New York Heart Association classification scheme for classification of cardiac function.Results The plasma BNP concentration in HF group was higher than that of the control group( P 0.05).The plasma BNP concentration increased in patients with HF heart function grade,and the difference between the groups was statistically significant.Conclusion Plasma BNP is an objective index to reflect the cardiac function,having an important significance in diagnosis and cardiac function evaluation of heart failure.
Brain natriuretic peptide
Clinical Significance
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Atrial natriuretic peptide
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The aim of the study was to determine the value of brain natriuretic peptide for the identification of diastolic dysfunction status in congestive heart failure. We studied 204 patients with stable heart failure. Brain natriuretic peptide plasma levels were correlated with echocardiographic parameters of diastolic dysfunction. Diastolic dysfunction was classified as mild (abnormal echocardiographic relaxation pattern) and severe (pseudo-normal or restrictive pattern). A significant correlation between brain natriuretic peptide levels and the other parameters was detected. Brain natriuretic peptide dosage, then, seems to be a reliable tool for the assessment of diastolic dysfunction status in patients with congestive heart failure.
Brain natriuretic peptide
Diastolic heart failure
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Influence on plasma brain natriuretic peptide level by use of Ibesartan for congestive heart failure
Objective: To observe plasma Brain Natriuretic Peptide level by use of Ibesartan for congestive heart failure.Methods: We chose 78 heart failure patients with Ⅲ-Ⅳ New York Heart Association(NYHA)functional classification,and used Ibesartan on the basis of traditional treatment,then observed the changement of plasma Brain Natriuretic Peptide level during treatment.Results: After treatment,patients' heart rate,blood pressure,LVDd all descended,but LVEF increased.The Value of BNP declined obviously,after the use of the Ibesartan.Conclusion: We treated congestive heart failure with Ibesartan,the availability ratio was more than 90%,and the value of BNP declined obvious1y.It implied dynamic monitoring plasma Brain Natriuretic Peptide was helpful in understanding treatment effect and prognosis.
Brain natriuretic peptide
Plasma levels
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Brain natriuretic peptide
Ventricular Function
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