Intravesical instillation of MMC adding IFN-α2b for preventing postoperative recurrence of bladder cancer
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Objective To investigate the effective method for preventing the postoperative recurrence of bladder cancer. Methods 62 cases of bladder cancer were treated by conservative bladder operations including TURBt and partial cystectomy,and followed by postoperative intravesical instillation of MMC adding IFN-α2b. 68 cases of bladder cancer as control group were treated by identical operations and instilled with MMC after operation only.The preventive effect of two groups was compared. Results The recurrence rate of MMC+IFN group was 8.5%,which was less than MMC group,and the side-effects occurred in MMC+IFN group were very mild. Conclusions Intravesical instillation of MMC adding IFN-α2b is an effecfive method for preventing recurrence of bladder cancer.Keywords:
Cancer recurrence
Bladder Neoplasm
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Objective: To investigate the efficiency of bladder instillation of pirarubicin(THP) combined with mitomycin C(MMC) for prevention of TURBt postoperative superficial bladder urothelial carcinoma recurrence.Methods: A total of 78 patients underwent carcinoma of the urinary bladder surgery were randomly divided into two groups,one group(40 patients) was treated with bladder instillation of pirarubicin(THP) for a course of 12 months and the other(38 patients) was dealt with bladder instillation of mitomycin C(MMC) for 2 years.Recurrence and side effects were observed and compared.Results: In the THP group,2-year recurrence rate and adverse reaction rates were 15.0% and 27.5%,respectively,and the corresponding data of the MMC group were 28.9% and 31.6% of MMC group.Significant difference in recurrence rate was observed(P0.01).Conclusions: THP bladder perfusion shows better effeciency for prevention of postoperative recurrence of bladder cancer than MMC.MMC is also commonly used because it is cheaper.
Pirarubicin
Mitomycin C
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Purpose:To investigate the clinical results of intravesical instillation with MMC and BCG for the prevention of postoperative recurrence of bladder tumor.Methods:86 cases of patients with superficial bladder cancer were included in this study. All patients received intravesical instillation of 20 mg MMC or 60mg BCG in turn once a week postoperatively, and persisted for 12 weeks. Then intravesical instillation was performed every 3 months, persisted for 2 years.Results: All patients have been followed up for 2.4 to 8 years, with a average of 4.8 years. The recurrent rate was 8.1 %.Conclusions:Intravesical instillation of MMC and BCG in turn are effective for reducing the postoperative recurrence rate of bladder tumor.
Bladder tumor
Bladder Neoplasm
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Objective:To evaluate the efficacy and safety of immediate submucosal injection of pirarubicin(THP)combined with intravesical instillation of mitomycin(MMC)after TURBT in patients with non-muscle invasive bladder cancer.Method:The data of 63 patients with bladder urothelial cell carcinoma underwent TURBT were retrospectively analyzed.After immediate injected of THP after TURBT,the patients were received postoperative intravesical instillation of MMC once a week for eight weeks,later once every two weeks for four months, and at last once a month for six months.Cystoscopy was taken once every three months postoperatively.Result: The recurrence rate was 15.9% after follow-up period of 2 months-3 years.Six cases of side effects,one case of systemic bone metastasis and one case of death took place during intravesical instillation of MMC within three years postoperatively.Conclusion:Postoperative prophylactic submucosal injection of THP combined with regular intravesical instillation of MMC is effective and safe for prevention of recurence of bladder carcinoma after the operation.
Pirarubicin
Mitomycin C
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Objective To evaluate the seguential and alternate intravesical instillation of MMC BCG and THP for the prevention of bladder cancer recurrence.Methods The instillation was carrid out for 44 cases of bladder cancer after surgical management.All the patients have been followed up for 4-48 months an average of 30 months.Results The recurrence rate was 6.8%(3/44),all of them underment TURBT of TVBT.Conclusion Seguential and alternate intravesical instilation of MMC BCG and THP is an effective means of preventing bladder cancer recurrence.
Cancer recurrence
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Objective To investigate the possible mechanism and the efficacy of combined intravesical instillation of the MMC and HPC in the prophylaxis of local recurrence after resection of bladder cancer. Methods 36 patients with urinary bladder tumor were observed in the present study, 18 patients were administered with 1% HPC-MMC instilled into the urinary bladder and the other were administered conventional aqueous MMC after TURBT. The recurrence rate and side effect rate were compared in both group. Results The recurrence rate of MMC group is 33.33%(6/18), the recurrence rate of HPC-MMC group is 11.11%(2/18), the side effect rate of MMC group is 38.88%(7/18), the side effect of HPC-MMC group is 33.33%(6/18). Conclusions Combined intravesical instillation of the MMC and HPC could keep longer MMC in urine and could be effective against local recurrence of bladder cancer without additional side effects.
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Objective To evaluate the alternate intravesical instillation of MMC and IL 2 together with BCG for the prevention of bladder cancer recurrence. Methods The instillation was carried out for 41 cases of bladder cancer after surgical management.All the patients have been followed up for 38～66 months with an average of 50 months.TNFa levels were periodically detected after the instillation. Results No recurrence has been noted in all the 34 patients of Ta,T 1 and T 2 tumors except 1 with mixed squamous cancer. 3 of 7 T 3 cases underwent TURBT,recurrence was noted in 2 and the TNFa remained much higher after the instillation. Conclusions Alternate intravesical instillation of MMC and IL 2 together with BCG is an effective means of preventing bladder cancer recurrence.TNFa detection might serve as a marker for bladder cancer recurrence.
Bladder tumor
Bladder Neoplasm
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Objective: To evaluate the clinical effects of bladder instillation with mitomycin C(MMC) and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer.Methods: A total of 126 patients with superficial bladder cancer were randomly divided into MMC and pirarubicin group.The MMC group were treated with 30 mg of MMC and 30 ml of 0.9% sodium chloride injection through bladder instillation for 2 hours.The pirarubicin group were treated with 30 mg of pirarubicin and 30 ml of 5% glucose injection through bladder instillation for 30 minutes.The safety and postoperative recurrence of superficial bladder cancer in two groups were observed.Results: All patients were followed up for 24 months.The recurrence rates of MMC and pirarubicin group were 14.3% and 13.7%,the difference of which had no statistical significance and the tumour progression of two groups had no statistical significance(P 0.05).The incidence rates of chemical cystitis in MMC and pirarubicin group were 32.0% and 38.5%,the difference of which had no statistical significance(P 0.05).The adverse drug reactions of two groups were not obvious.Conclusions: The clinical effects of bladder instillation with MMC and pirarubicin on preventing the postoperative recurrence of superficial bladder cancer are similar.These two drugs can be used as the preferred drug for clinical bladder instillation.
Pirarubicin
Mitomycin C
Clinical Significance
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Purpose:To evaluate the early effect of intravesical instillation of pirarubicin (THP) for prevention of postoperative recurrence of superficial bladder cancer.Methods:Transurethral resection or partial cystectomy was performed on 34 patients with superficial bladder cancer , followed by THP intravesical instillation once a week for 8 weeks and then once a month until 1 year after surgery.Results:All patients have been followed up for 10 to 12 months . It showed that tumor recurrence occurred only in 2 patients (5.9%) .No systemic adverse reaction has been observed, and only 5 patients have transitory bladder irritation. Conclusions: Postoperative intravesical instillation of THP for superficial bladder cancer has good prophylactic effects on the recurrence with least side effects.
Pirarubicin
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Objective :To discuss the outcoming of treating with mitomycin C(MMC) after TUVBt as a treatment of superficial bladder carcinoma.Method:Retrospectively study of 46 cases from 1999 to 2005,underwent TUVBT.Result:Postoperation all the patients received mitomycin C(MMC) intravesical instillation.no one was recurrence in 33 cases followup duration 36 months,7 case recurrence.Conclusion :TUVBT is less invasive,with clear visual field,definitive resection depth,and less recurrence in treatment of superficial bladder carcinoma.
Mitomycin C
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Objective To compare the effect and safety of pirarubicin (THP) and mitomycin (MMC) by bladder instillation after transurethral resection of superficial bladder urothelial carcinoma.Methods Fourty seven patients of superficial bladder urothelial carcinoma after transurethral resection were randomly divided into two groups to receive intravesical instillation of THP or MMC,respectively.Periodical cystoscopy and blood, urine, liver and kidney function tests were performed in all, observe the efficacy and side effects.Results The tumor recurrent rate in THP group and MMC group were(8.7%)and(16.7%),respectively.The tumor recurrent rate of THP group differed significantly from the MMC group(P0.05). The recurrent rate of the bladder irritation in THP group and MMC group were(8.7%)and(12.5%),respectively.The recurrent rate of the bladder irritation of THP group differed significantly from the MMC group(P0.05).and there was 1 case of pirarubicin dysuria in THP.Conclusion Intravesical administration of THP after operation was mole effective than MMC,which had the merit of short duration,shorter period of treatmeat,and more convenience for preventing tumor recurrence.
Pirarubicin
Dysuria
Mitomycin C
Bladder tumor
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