INTRAHEPATIC ADVANCE PATTERN OF THE SOLITARY LIVER METASTASIS FROM COLORECTAL CANCER
Yasuki UnemuraShuichi FujiokaTakashi ImaiTomoyuki SaekiYoshiaki TanabeKatsumaro SUZUKITakeyuki MisawaSusumu KobayashiYoji Yamazaki
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Abstract:
Intrahepatic advance pattern of solitary metastatic liver tumor from colorectal cancer was considered on the basis of the classification according to pre- and intra-operative information in a series of 33 resected cases at the hospital. Small nodule; less than 3cm in tumor diameter, large nodule; more than 3cm, and proliferat-ing nodule; macroscopic existence of marginal proliferating form were defined, and the tumors were classi-fied into the following three types. 1) Small nodular type (S): both 3- and 5-year survival rates were 38%. Remnant liver recurrence was so high in the synchronously metastasized patients, whereas good prognosis in the metachronously metastasized patients. 2) Large nodular type (L): 3- and 5-year survival rates were 66 %and 54% respectively, and no prognostic difference about the distinction of metastasized period was seen. Mean diameter of the tumors specimen was 4.2±1.7cm (mean±S.D.). 3) Proliferating large nodular type (PL): the prognosis was as extremely poor as 1- and 2-year survivals were 33% and 0% respectively. The diameter of the tumor was 9.2±3.5cm, thus PL was considered as the clinically advanced type of L. We believe, that the intrahepatic advance pattern of solitary metastatic liver tumor from colorectal cancer can be pre-dicted pre- and intraoperatively by our classification, and the prediction is properly useful to the therapeutic planning.Keywords:
Nodule (geology)
Purpose:Tumor metastasis is the main cause of tumor death and poor long term effect in clinical treatment. In the process of metastasis, tumor cell adhesion is one of the key steps. It has been shown that P selectin and its ligands were related to tumor infiltration, invasion and the generation of metastastic lesions, and may be a prognostic factor or metastasis index. But the relationship between platelet P selectin and tumor emboli/metastasis need to be further investigated.
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P-selectin
Primary tumor
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Objective To detect the expression and role of PTTG mRNA in human colorectal cancer.Methods The expression of PTTG mRNA was evaluated in 12 normal colorectal tissues,20 colorectal adenoma tissues and 44 colorectal cancer tissues by RT-PCR.Results The expression of PTTG mRNA in colorectal cancer was significantly higher than that in colorectal adenoma and normal colorectal tissues.The PTTG mRNA expression in the Dukes C,D colorectal cancer was higher than that in the Dukes A,B cancer(P0.05).The expression in the colorectal cancer with lymph node metastasis was higher than that in the cancer without lymph node metastasis(P0.05).Conclusion The expression of PTTG mRNA increases in colorectal cancer,and is related with cell differentiation and metastasis.The abnormal expression of PTTG probably participates in genesis and development of colorectal cancers.
Colorectal adenoma
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Seedlings of Myrica gale were grown aeroponically and inoculated with suspensions prepared from mature nodules of M gale plants or with a homogenized preparation of a pure culture of the actinomycete isolated from Comptonia nodules. Morphological, anatomical, and cytological studies were made of early nodule development in these plants, and comparisons were made with similar stages in Comptonia and Casuarina Root hair infection was followed by prenodule formation in a manner similar to that in Comptonia In M. gale, most nodules originated with one or two primary nodule lobes. Thereafter, secondary nodule lobes formed sparsely and in a precisely ordered sequence. In 3-mo-old seedlings, nodules with up to five nodule lobes were observed, but the majority of nodules at this age were still one-to-three lobed In Comptonia the number of primary nodule lobes is much higher than in M. gale. In M. gale nodule roots developed from many but not all nodule lobes, usually in an ordered sequence.
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In this case report, we present a pleomorphic adenoma that presented as a hard nodule on the upper lip in a man in his 30s. Differential diagnosis is necessary, as there are multiple causes of a nodule in the lip. The nodule was excised extracapsularly and a histopathological examination was performed. Although the tumor was found to be benign, there is a risk of late malignant conversion, which underscores the importance of prompt treatment.
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