Epidemiological study of consanguineous marriage and its effects
3
Citation
18
Reference
10
Related Paper
Citation Trend
Abstract:
Background: Consanguinity increases the risk of congenital anomalies, autosomal recessive disorders, perinatal and antenatal morbidities. The objective of this study was to know the effects of consanguineous marriages and educate the people regarding the effects of the same.Methods:A community based Cross Sectional study was conducted amongst 130 married couples in the field practice area of KBNIMS, Kalaburgi, Karnataka, India by using simple random sampling technique. Data was collected in pre designed pre tested questionnaire.Results: Out of 130 married couples, 58 were consanguineously marriage (44.6%). Among these families, consanguineous marriages were more in Muslim families (56.05%) as compared to Hindu families (25%). Prevalence of abortions and preterm deliveries was noted to be 60% and 64.28% respectively in consanguineous marriages. It had been witnessed that 66.6% of hearing defects in the community were in consanguineous families and a 100% of all vision defects were seen in consanguineous conceptions.Conclusions:As per the study it was found that the prevalence of consanguinity was more in the Muslim population than in Hindu population. Maternal and child morbidity were more prevalent in consanguineous marriages as compared to non-consanguineous marriages. There is a lack of awareness and knowledge about the ill effects of consanguinity. Health education and genetic screening were suggested to curb consanguineous marriages in order to prevent adverse outcomes for better health.Keywords:
Consanguineous Marriage
Introduction: India has been subdivided in to two major regions with respect to a preference for or avoidance of consanguineous marriage. The deleterious health effects associated with consanguinity are caused by the expression of rare, recessive genes inherited from common ancestors. Objectives: To find out the prevalence and types of consanguinity and reproductive behaviour in rural area of Nagpur district. Methodology: study design: cross sectional study. Setting: Raipura village, a field practise area of Indira Gandhi Government Medical College, Nagpur. Study population: married couples. Result: The prevalence of consanguineous marriage in study couple was 16.43%. Most prevalent type of consanguineous marriage was seen in mother’s brother’s daughter type (73.04%). Significant association found in study couples and consanguinity in their parents. No significant effect of consanguinity was observed on foetal loss, neonatal mortality but significant association was found with congenital malformations.
Consanguineous Marriage
Daughter
Cite
Citations (2)
Background: Consanguinity increases the risk of congenital anomalies, autosomal recessive disorders, perinatal and antenatal morbidities. The objective of this study was to know the effects of consanguineous marriages and educate the people regarding the effects of the same.Methods:A community based Cross Sectional study was conducted amongst 130 married couples in the field practice area of KBNIMS, Kalaburgi, Karnataka, India by using simple random sampling technique. Data was collected in pre designed pre tested questionnaire.Results: Out of 130 married couples, 58 were consanguineously marriage (44.6%). Among these families, consanguineous marriages were more in Muslim families (56.05%) as compared to Hindu families (25%). Prevalence of abortions and preterm deliveries was noted to be 60% and 64.28% respectively in consanguineous marriages. It had been witnessed that 66.6% of hearing defects in the community were in consanguineous families and a 100% of all vision defects were seen in consanguineous conceptions.Conclusions:As per the study it was found that the prevalence of consanguinity was more in the Muslim population than in Hindu population. Maternal and child morbidity were more prevalent in consanguineous marriages as compared to non-consanguineous marriages. There is a lack of awareness and knowledge about the ill effects of consanguinity. Health education and genetic screening were suggested to curb consanguineous marriages in order to prevent adverse outcomes for better health.
Consanguineous Marriage
Cite
Citations (3)
Consanguinity has been shown to increase homozygosity and to reduce genetic variation in a group, which may protect against the expression of recessive genes that can lead to genetic disorders. Consanguineous marriages are practised widely in Kuwait. The major aim of this study is to delineate the association of consanguineous marriages with congenital disabilities in different Kuwaiti population subcultures. A total of 9104 married Kuwaiti females aged 15-79 years from different backgrounds were selected at ten primary health care centres from six governorates in Kuwait. Data were collected using a questionnaire and analysed with chi-squared tests. The data indicate significant differences in the occurrence of genetic diseases in consanguineous couples' offspring (4.88%) compared with those of non-consanguineous couples (4.13%) (p<0.002). The results also show significant differences in frequencies of genetic/environmental diseases in consanguineous couples' offspring (8.59%) compared with those of non-consanguineous couples (8.23%) (p<0.005). No significant differences between the two groups regarding environmental diseases were observed. A higher frequency of genetic diseases was found in first- (6.97%; p<0.001), second- (6.78%; p<0.001) and third-cousin (6.46%; p<0.022) couples' offspring compared with those of non-consanguineous couples. The frequency of congenital disabilities in the offspring of couples from consanguineous marriages (2.9%) is higher than that in the offspring of non-consanguineous marriages (2.3%). But this difference is not significant at the 0.05 level. First-cousin marriages have the highest frequency (3.5%) of congenital disabilities compared with other kinds of marriages (2.1-2.3%). Differences across groups are significant (p<0.036). Significant differences are found for first-cousin couples in both physical (2.37; p<0.042) and mental (0.74; p<0.037) disabilities compared with non-consanguineous couples. No significant differences were observed in deafness and blindness disabilities. The data show no significant differences between second- and third-cousin and non-consanguineous couples in physical, mental or deafness and blindness disabilities. There are no significant differences in the percentages of offspring with congenital disabilities in consanguineous and non-consanguineous marriages across sub-population groups for the total of four types of congenital disability.
Consanguineous Marriage
Cousin
Cite
Citations (24)
Turkey has a high rate of consanguineous marriages. Different nationwide surveys indicate that today 20-25% of marriages are consanguineous, with the rate having increased over the last 15 years. The results of many studies show that the rate of consanguinity among parents of children with rare recessive diseases is quite above Turkey's average and that the high consanguinity rate is one of the underlying factors of high infant and child mortality and fertility in Turkey.
Consanguineous Marriage
Total fertility rate
Cite
Citations (86)
Although consanguinity is widely practiced in Oman, the attitude of community towards consanguinity and the awareness of its health consequences to offspring remain largely unexplored.To analyse the levels and trends of consanguineous marriage and examine community awareness about congenital anomaly associated with consanguinity and attitude towards consanguinity in Oman.The data come from a nationally representative survey on Omani adults of age 18 years and above, irrespective of their marital status. Data were analysed using both descriptive and multivariate statistical techniques.The survey results indicate a very high rate (49%) of consanguineous marriage in Oman. There is a declining trend in consanguinity which may be attributed to decline in first cousin marriage. Omani adults have moderately high knowledge (69%) about health consequences of consanguineous marriage. There is a high positive attitude towards consanguineous marriage (75%) which appeared as a significant predictor of current practice of consanguineous marriage in Oman.The positive attitude of the Omani community towards consanguinity outweighs the negative health consequences of consanguinity, and the practice is likely to remain high in the near future. Strong educational and motivational programmes are needed to bring further changes in attitude towards consanguinity and, thus, reduce the burden of congenital anomalies associated with consanguinity in Oman.
Consanguineous Marriage
Marital status
Cite
Citations (28)
Consanguineous Marriage
Cite
Citations (2)
SummaryNineteen Arab children including six boys and 13 girls in ten sibships were diagnosed as having osteopetrosis over a 5-year period in various hospitals in Kuwait. Eighteen patients had an isolated autosomal recessive form and one had autosomal recessive osteopetrosis associated with renal tubular acidosis. The mean age of diagnosis was 24 months. Parental consanguinity was high amongst them (68%). Anaemia, hepatosplenomegaly, failure to thrive, recurrent infections and neurological manifestations were common. Associated congenital abnormalities were found in 26%. Deafiiess, hydrocephalus and dental caries were relatively less common. A high mortality (37%) owing to infection was noted. The medical management and recommendations for patient care are discussed briefly.
Osteopetrosis
Osteochondrodysplasia
Cite
Citations (14)
Background: In Saudi Arabia there is still a high prevalence of consanguineous marriage in spite of increased educational level. This may be attributed to the fact that this practice is more influenced by attitude towards this type of marriage rather than educational level. The Aim of this study was to determine knowledge and attitude towards consanguineous marriages among educated Saudi adults.Methods: A cross sectional study was conducted using an online questionnaire. A total of 680 educated Saudi adults living in Riyadh were asked about their socio-demographic characteristics, their knowledge and attitude towards consanguineous marriage.Results: Most of participants had poor knowledge and negative attitude (53.31% and 57.21% respectively). One third of participants had no idea about the possibility that consanguineous couples may have diseased offspring more than non-consanguineous couples. Those who had significantly higher attitude score towards consanguineous marriage were older age group, males, those who are married to their relatives, people who have frequent family history of consanguineous marriage and participants with parental consanguinity. Attitude towards consanguineous marriage can be predicted by age and knowledge.Conclusions: Changing the attitude can be done by changing level of knowledge. So, educational programs are recommended and should be directed to groups with higher attitude score.
Consanguineous Marriage
Positive attitude
Educational Attainment
Cite
Citations (10)
Background: A marriage is said to be consanguineous, where the marriages are solemnized among persons descending from the same stock or common ancestor with close biological relations. The aim of the study was to role of consanguinity in paediatric neurological disorders. Methods: The cases of the present study were selected from various units of paediatric ward in Velammal medical college hospital, Madurai, Tamilnadu, India, over a period of 2 years between Nov-2013 to oct-2015. This is a prospective observational study of 152 children, out of which 83 children were products of non-consanguineous with neurological disorders and 69 children were products of consanguineous marriage with neurological disorders, confirmed by history and clinical examination and correlated with appropriate investigations. Results: It was found that out of 152 neurological cases admitted, during the study period, 69 (45.3%) of patients were products of consanguineous marriage and 83 (54.6%) were products of non-consanguineous marriage. Out of 69 cases that were product of consanguineous marriage, 27 cases (39.1%) born of second degree consanguinity and 42 cases (60.8%) were products of third degree consanguinity. Out of the 69 cases, 7 (10.1 %) of them had siblings with similar neurological problems. The prevalence of seizure disorder was 27 (17.7%), developmental delay 13 (8.5%), isolated speech delay 2 (1.3%), hearing impairment 5 (3.2%), mental retardation 11 (7.2%), visual impairment 2 (1.3%), ataxia telangiectasia 2 (1.3%) among the products of consanguineous marriage. The above stated prevalence of neurological disorders being slightly higher than that of the products of non-consanguineous marriage. Conclusions: It is important to prevent hereditary diseases that are associated with consanguineous marriage through public education.
Consanguineous Marriage
Neurological examination
Cite
Citations (8)
This cross-sectional study was carried out to investigate the frequency of consanguineous marriage in a group of army conscripts in Ankara and the factors affecting this. Of 4153 soldiers, 387 were married. The rate of marriage between first cousins was found to be 19·1%, and the overall rate of consanguineous marriage was 24·1%. Consanguineous marriage was found to be significantly prevalent among soldiers who were born in and still living in the Eastern region; among those who lived in villages; among those whose parents as well as themselves had low educational levels; and among those whose marriages were arranged by their families. Neither the payment of bride-price nor the presence of consanguinity between parents was a significant factor for consanguineous marriage. In addition, the age of the soldier and the age at marriage were significantly lower among soldiers married to first cousins than among soldiers whose marriages were not consanguineous.
Consanguineous Marriage
Cite
Citations (12)