Effects of Exercise on Patients with Endometrial Cancer
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Endometrial cancer is the most common gynecological cancer affecting post-menopausal women. It has been well documented that old age, estrogen overexposure, obesity and physical inactivity are major risk factors contributing to the development of endometrial cancer. Increased physical activity or exercise can alleviate disease- and treatment-related symptoms and improve quality of life of cancer patients during and after treatment. However, few studies have been focused the effects of physical exercise for patients that were treated for endometrial cancer. This paper aims to provide an over view of the course and treatment of endometrial cancer, cancer- and treatment-related symptoms, and the effects of physical exercise.Keywords:
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New reliable approaches to stratify patients with endometrial cancer into risk categories are highly needed. We have recently demonstrated that DJ-1 is overexpressed in endometrial cancer, showing significantly higher levels both in serum and tissue of patients with high-risk endometrial cancer compared with low-risk endometrial cancer. In this experimental study, we further extended our observation, evaluating the role of DJ-1 as an accurate serum biomarker for high-risk endometrial cancer. A total of 101 endometrial cancer patients and 44 healthy subjects were prospectively recruited. DJ-1 serum levels were evaluated comparing cases and controls and, among endometrial cancer patients, between high- and low-risk patients. The results demonstrate that DJ-1 levels are significantly higher in cases versus controls and in high- versus low-risk patients. The receiver operating characteristic curve analysis shows that DJ-1 has a very good diagnostic accuracy in discriminating endometrial cancer patients versus controls and an excellent accuracy in distinguishing, among endometrial cancer patients, low- from high-risk cases. DJ-1 sensitivity and specificity are the highest when high- and low-risk patients are compared, reaching the value of 95% and 99%, respectively. Moreover, DJ-1 serum levels seem to be correlated with worsening of the endometrial cancer grade and histotype, making it a reliable tool in the preoperative decision-making process.
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Endometrial cancer is the most common gynecological cancer affecting post-menopausal women. It has been well documented that old age, estrogen overexposure, obesity and physical inactivity are major risk factors contributing to the development of endometrial cancer. Increased physical activity or exercise can alleviate disease- and treatment-related symptoms and improve quality of life of cancer patients during and after treatment. However, few studies have been focused the effects of physical exercise for patients that were treated for endometrial cancer. This paper aims to provide an over view of the course and treatment of endometrial cancer, cancer- and treatment-related symptoms, and the effects of physical exercise.
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This study aims to determine the relationship between physical exercise and obesity in adolescents. The method used is a systematic review using four databases: ClinicalKey Nursing, Emerald Insight, Sage Journals, and ScienceDirect. The results showed that of the thirteen articles reviewed, nine pieces showed that regular physical exercise could reduce body weight, body mass index (BMI), body fat percentage, and body composition. Physical exercise is also related to obesity status and is a strategy to control obesity as well as an obesity prevention factor which is not only recommended to prevent obesity but can maintain a healthy body; lack of physical exercise can increase the risk of obesity by 3.08 times greater than adolescents who do exercise physique. Four other articles stated that obesity in adolescents was not directly related to physical exercise. Still, they reported the occurrence of obesity due to food consumption habits that can increase body fat. In conclusion, physical exercise is recommended as a strategy for preventing and managing obesity. It is associated with obesity status in adolescents, which can be known from the value of body mass index (BMI).
Keywords: Physical Exercise, Obesity, Adolescents
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Introduction: The health benefits of regular physical activity alone are real, and the World Health Organisation has afforded great importance to the issue of obesity, and considers it to be an epidemic, which is threatening global health. Despite the fact that the subject of obesity emerged in developed countries, Arab countries began experiencing this phenomenon, due to changes in lifestyle among its citizens. Physical activity may favourably affect body fat distribution. Our study aims to study the impact of physical activity and exercise on obesity. Method: The research sample was 165 adolescents with an average age of 17.8 years old. A questionnaire was used to estimate physical activity and exercise. The body mass index (BMI) is used to determine obesity. Result: The results of the study indicated that there is a relationship between physical activity and exercise and obesity, and also between the amount of exercise and type of physical activity and obesity. Conclusion: Physical activity and exercise have an impact on obesity. Through the study results, we recommend the importance of physical activity and exercise for teenagers, because the continuous practice of physical activity reduces obesity.
Keywords: obesity, physical activity and exercise, adolescence.
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Endometrial cancer is the fifth most common cancer diagnosed in women in developed countries. This research used genetics to assess relationships between endometrial cancer and, previously identified and novel, risk factors. This work brings new insights by providing evidence that HDL and LDL cholesterol levels are linked to endometrial cancer risk. Further, I have shown that two gynaecological diseases, which are comorbid with endometrial cancer, also share genetic risk architecture with endometrial cancer. This work also advances the understanding of biological mechanisms of endometrial cancer by identifying candidate susceptibility genes.
Epidemiology of cancer
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To determine whether physical activity enjoyment mediated the association between motivation and physical activity in patients with heart failure.
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Abstract Background: The analysis of long non-coding RNA (lncRNA) in endometrial cancer is quite a novel field of science. Although numerous lncRNA sequences have been identified up until today, their correlation with endometrial cancer is still undetermined. The aim of this study was to analyse the expression of four lncRNA sequences: FAM3D-AS1 , LINC01230 , LINC01315 and LINC01468 and to investigate their significance in the risk of developing endometrial cancer.Methods: LncRNA sequences have been investigated in paraffin embedded tissue blocks (archival postoperative specimens) in endometrial cancer patients (Cases, n=120) and in cancer-free controls (n=80) using real-time PCR assay.Results: This study revealed a lower expression of LINC01468 in endometrial cancer patients than in controls. Both LINC01468 and FAM3D-AS1 were positively correlated with Body Mass Index (BMI) in cancer-free controls.Conclusions: LncRNA LINC01468 may be a protective factor in development of endometrial cancer.
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Key content Of the 20 most common tumour types, endometrial cancer has the strongest association with obesity. Endometrial cancer should be considered in young, obese women with irregular or heavy menstrual bleeding. To reduce the risk of postoperative complications, surgery for endometrial cancer should be performed using minimal access techniques whenever possible. For women who are unfit for, or who decline, surgery, alternative treatments include progestins or radiotherapy, but these have lower efficacy and are associated with a higher risk of disease relapse. Obesity is associated with reduced overall survival following endometrial cancer because of increased cardiovascular mortality; it may also affect disease‐specific survival. Learning objectives To further understanding of the mechanisms through which obesity drives endometrial carcinogenesis. To improve understanding of the potential difficulties associated with the management of endometrial cancer in obese women. To increase knowledge of alternative treatment options for women who are unfit for, or who decline, standard endometrial cancer management. Ethical issues The number of young, premenopausal women with endometrial cancer is increasing – how should these women be managed? Should super‐obese women with endometrial cancer only be treated in cancer centres? After treating a woman's endometrial cancer, how should she be counselled her about her weight and cardiovascular disease risk?
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