Does ispaghula husk stimulate the entire colon in diverticular disease?
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Abstract:
The effect of ispaghula husk on colonic motility of the right and left side was examined in 10 patients with left sided diverticular disease using an untethered pressure sensitive radiotelemetry capsule. After treatment, ispaghula husk reduced mouth to rectum transit by a median of 8.8 hours and the time to midtransverse colon by five hours. In the right colon there was an increase in the median percentage activity of 7% and the median number of pressure waves greater than 5 mm Hg/hour rose by 35.3. Motility changes in the left colon were less pronounced. Five of the seven patients with abdominal pain and six of the nine patients with altered bowel habit responded to treatment. These results suggest that it is ispaghula husk9s action on the right unaffected colon which alleviates the symptoms of left sided diverticular disease.Keywords:
Diverticular disease
Rectosigmoid Colon
Abstract Carcinomas, nodes, and metastases arising from the colon and rectum have been classified clinically and pathologically. Primary sites include the colon, rectosigmoid junction, and the rectum. Clinical assessment is based on physical examination, imaging, endoscopy, and/or surgical exploration. Factors that influence prognosis have been included.
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THIS statistical study covers all patients with carcinoma of the rectum and rectosigmoid admitted to the Veterans Administration Hospital, Hines, Ill., from 1931 to 1946. This institution has been the tumor center for all Veterans Administration hospitals in the Middle West and the southern states, and there has been accumulated a wealth of material for study and analysis. The total number of patients admitted to the institution for the fifteen year period has been 131,279. Of this number, 16,097 have been admitted for malignant tumors. There have been 1,341 cases of carcinoma of the colon and rectum; in 844 of these there was carcinoma of the rectum and rectosigmoid, and in 497 there was carcinoma of the remainder of the colon.
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Character of Symptoms.
—The frequency of the most important symptoms in 400 male patients suffering with carcinoma of the rectum and rectosigmoid is given in table 1. TheseRectosigmoid Colon
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Rectal involvement by prostatic carcinoma: barium enema findingsSE Rubesin, MS Levine, M Bezzi, HM Pollack, I Laufer, H Herlinger and G HarrisAudio Available | Share
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The effect of ispaghula husk on colonic motility of the right and left side was examined in 10 patients with left sided diverticular disease using an untethered pressure sensitive radiotelemetry capsule. After treatment, ispaghula husk reduced mouth to rectum transit by a median of 8.8 hours and the time to midtransverse colon by five hours. In the right colon there was an increase in the median percentage activity of 7% and the median number of pressure waves greater than 5 mm Hg/hour rose by 35.3. Motility changes in the left colon were less pronounced. Five of the seven patients with abdominal pain and six of the nine patients with altered bowel habit responded to treatment. These results suggest that it is ispaghula husk9s action on the right unaffected colon which alleviates the symptoms of left sided diverticular disease.
Diverticular disease
Rectosigmoid Colon
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Operative experiments on laboratory animals and roentgen studies on man have yielded most of the knowledge concerning the muscular activity of the colon. The information obtained with the roentgen rays is limited because only gross changes are revealed. Operative experiments on animals also have some shortcomings due to inability to elicit subjective symptoms or to the abnormal conditions which anesthesia and surgical intervention represent. This is a study of the movements of the rectum before and after a meal and further shows the symptoms produced by the prolonged presence of a mass in the rectum. A balloon inserted into the lower colon of man through a proctoscope and filled with water has served as a medium for recording movements of the colon. Although the lower bowl was emptied of fecal matter before the experiment started, the results are interpreted as applying to a filled colon because the size and shape
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There is a sound radiobiologic basis for the combined use of preoperative radiation therapy and surgery in the treatment of operable carcinoma of the rectum and rectosigmoid. It is recommended that a planned joint effort be made by surgeons and radiation therapists to evaluate the place of radiation therapy for carcinoma of the rectum and rectosigmoid. There is evidence that preoperative radiation therapy will improve the survival of patients who have metastases to the regional lymphatics and that pelvic recurrence can be eliminated or reduced.
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