Pregnancy Outcome Following In Utero Exposure to Lithium: A Prospective, Comparative, Observational Study
Orna Diav‐CitrinSvetlana ShechtmanEsther TahoverVictoriya Finkel‐PekarskyJudy ArnonDebra KennedyAida ErebaraAdrienne EinarsonAsher Ornoy
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Lithium taken during the first trimester of pregnancy appears to increase the risk of cardiovascular anomalies in infants, although some of these anomalies resolve spontaneously. Lithium also raises the likelihood of miscarriage. On the other hand, the risk of illness recurrence is high for women who discontinue taking medication during pregnancy, and so the decision should be made on an individual basis. It is recommended that women treated with lithium during organogenesis receive fetal echocardiography and level-2 ultrasound.Abstract A healthy pregnant woman at 28 weeks of gestation was admitted with complete loss of fetal movement. Fetal heart rate (FHR) monitoring showed a fixed flat FHR pattern with no variability. Ultrasound examination revealed no fetal breathing movement. The fetus showed heart failure with extremely diminished left heart contractility. No abnormalities were found in the fetus. We assessed that the fetus was in a brain death‐like status. After discussion, we decided not to deliver the baby but to monitor it carefully using FHR monitoring and continuous fetal ultrasound examinations, assuming the baby was dying or at least had little possibility of survival. However, 8 h after admission, FHR monitoring showed some variability and after another 12 h the fetus recovered completely. The baby was born at 35 week of gestation by cesarean section. The baby sustained some white matter brain damage, but with no significant clinical delay of motor development. This is a rare case of in utero recovery from a fetal brain death‐like status.
Fetal movement
Cardiotocography
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AIM To investigate the effect of transplantation immunologic reaction of mouse by fetal liver cells utero injection. METHODS C57BL/6 fetal liver cells were injected intraperitoneally into the fetus of pregnant BALB/c mice at day 14 to 16 of gestation. At 7～9 weeks age, the surviving fe male fetus received transplantation of C57BL/6 newborn cardiac tissue grafts. Mice's cardiac tissue graft survival time after transplantation, mixture lymphocytes culture and delayed type hypersensitivity were observed to confirm the anti rejection effect of the method of fetal liver cells utero injection. RESULTS As compared to those in the control groups, the cardiac tissue graft's survival time after transplantation of the fetal liver utero injection group were prolonged ,and the other rejection datas of the utero injection group were significantly different from those of controls ( P 0.01). CONCLUSION Method of fetal liver cells utero injection can prolong the survival time of mice cardiac tissue graft. The suppression effect on rejection is efficient.
Intraperitoneal injection
Fetal Tissue Transplantation
Ratón
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ABSTRACT One of every five pregnancies ends in miscarriage, disputing the common misconception that miscarriage is rare. Early pregnancy loss has a complex impact on women's mental health, requiring compassionate, trauma-informed care. This article explores the emotional and psychological impacts of miscarriage, and strategies for nurses to support the needs of patients after a miscarriage.
Early Pregnancy Loss
Recurrent miscarriage
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Summary Techniques for sampling pure fetal blood, fetal skin and for fetal examination by fetoscopy are described in detail after experience gained in 151 diagnostic fetoscopies on 145 patients. Of particular importance were a real‐time scanner and a particle size analyser. The region of insertion of the umbilical cord into the placenta was the optimum site for obtaining pure fetal blood, and this was achieved in 136 out of 143 patients (95 per cent) sampled at 18 to 23 weeks gestation. This made maternal blood transfusion before prenatal diagnosis of haemoglobinopathies unnecessary. An anterior placenta rarely prevented successful fetoscopy, and often made fetal blood sampling easier. Four fetal losses (3·7 per cent) were judged to be due to fetoscopy.
Fetoscopy
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DELAYED parturition leads to quite different results, depending on the species, in its effects on the offspring. In some, like the rabbit with normally a gestation period of 30 to 32 days, the fetuses continue to grow if carried past term, but prolongation past 35 or occasionally 36 days is fatal to them in utero. In man, by contrast, weight gain ceases at about 42 weeks,93 and various signs of inadequate fetal nutrition supervene, but the fetus can survive in utero for many weeks, usually not encountering serious difficulty until delivery, which becomes hazardous even though the fetus is not . . .
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AbstrcatObjective:To investigate the effect of tolerance induction on rat liver transplantation by fetal hepatocytes utero injection.Methods:LOU/CN fetal hepatocytes were injected intraperitoneally into the fetus of pregnant CHN rats at day 14 to 16 of gestation.Heterotopic transplantation was carried out to the 7-9 weeks old surviving male fetus,using male LOU/CN livers. Rats' survival days after liver transplantation and mixture lymphocytes culture were observed to confirm the anti-rejection effect of the method of fetal hepatocytes utero injection.Results:As compared to those in the control groups, the survival time after transplantation of the utero injection group was prolonged ,and the mixture lymphocytes culture datas of the utero injection group were statistically significant(P0.01)Conclusion:The method of fetal hepatocytes utero injection can prolong the survival time of rat liver transplantion, the induction effect of immune tolerance effect is efficient.
Fetal Tissue Transplantation
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One of every five pregnancies ends in miscarriage, disputing the common misconception that miscarriage is rare. Early pregnancy loss has a complex impact on women's mental health, requiring compassionate, trauma-informed care. This article explores the emotional and psychological impacts of miscarriage, and strategies for nurses to support the needs of patients after a miscarriage.
Recurrent miscarriage
Early Pregnancy Loss
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One of every five pregnancies ends in miscarriage, disputing the common misconception that miscarriage is rare. Early pregnancy loss has a complex impact on women's mental health, requiring compassionate, trauma-informed care. This article explores the emotional and psychological impacts of miscarriage, and strategies for nurses to support the needs of patients after a miscarriage.
Recurrent miscarriage
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