Contribution of hydrophobic/hydrophilic modification on cationic chains of poly(ε-caprolactone)-graft-poly(dimethylamino ethylmethacrylate) amphiphilic co-polymer in gene delivery
Shangcong HanHaiying WanDaoshu LinShutao GuoHongxu DongJianhua ZhangLiandong DengRuming LiuHua TangAnjie Dong
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Keywords:
Cationic polymerization
Ethyl acrylate
Caprolactone
Zeta potential
Abstract In the present paper the results of the studies on the autoacceleration in polymerisation of ethyl and n ‐propyl acrylate are reported. The merits and demerits of both mechanisms proposed by BURNETT and DUNCAN have been critically discussed and the results have been interpreted, following BURNETT et al . It has been observed that the critical degree of conversion where the autoacceleration starts, increases with the decrease of the initiator concentration; for any particular concentration of the initiator it is higher for n ‐propyl acrylate than for ethyl acrylate.
Ethyl acrylate
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Abstract Summary: Novel, star‐shaped, amphiphilic block copolymers composed of fully degradable poly(caprolactone) were synthesized by sequential addition polymerization. In the first step, four‐arm macroinitiators were produced by ring‐opening polymerization of caprolactone by initiation with pentaerythritol. Then, block copolymers were synthesized by sequential addition of 4‐(2‐benzyloxyethyl)‐ ε ‐caprolactone to the four‐arm macroinitiators. Star‐shaped, amphiphilic block copolymers containing poly(caprolactone)‐ block ‐poly[4‐(2‐hydroxyethyl)caprolactone] segments were obtained by catalytic debenzylation. Four‐arm amphiphilic polycaprolactone star block copolymer. image Four‐arm amphiphilic polycaprolactone star block copolymer.
Polycaprolactone
Caprolactone
Pentaerythritol
Star (game theory)
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Patch test
Ethyl acrylate
Patch Testing
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Data on allergic contact dermatitis from acrylates and 4 patients sensitized during routine patch testing are reported. During 1982-1985, we used 7 different acrylates for tests. 1 patient out of 22 (= 4.5%) was sensitized to ethyl acrylate and butyl acrylate (1% pet.). Since September 1985, we have used a commercial (meth)acrylate series containing 28 substances. 3 of 24 patients tested became sensitized to ethyl acrylate, 2-hydroxyethyl acrylate and 2-hydroxypropyl acrylate (0.5% pet.). Because active sensitization with acrylates can be very harmful, it may be necessary to use lower concentrations than recommended. Currently, we test ethyl acrylate, 2-hydroxyethyl acrylate and 2-hydroxypropyl acrylate at 0.167% pet.
Ethyl acrylate
Patch test
Patch Testing
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With ethyl methacrylate,butyl acrylate,2-hydroxy ethyl methacrylate,methacrylic acid 2,2,2-trifluoroethyl ester as the raw materials,fluoro-acrylate copolymer are prepared by solution polymerization.The hardness,adhesion,waterproofness,solvent resistance and surface performance are determined.The testing result indicates that the films made by fluoro-acrylate copolymer solution have better properties than those made by pure acrylate copolymer.
Ethyl acrylate
Butyl acrylate
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Ethyl acrylate
Methyl acrylate
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Abstract The aminocyanopentenedioate (I) dimerizes in refluxing pyridine to give the pyridinedione (II) as the major product.
Ethyl acrylate
Ethyl ester
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Delivering a missing gene or a functional substitute of a defective gene has the potential to revolutionize current medical care. Of the two gene delivery approaches, viral and synthetic vectors, synthetic cationic vectors possess several practical advantages but suffer from poor transfection efficiency. A new approach to gene delivery using charge-reversal amphiphiles is described. This synthetic vector transforms from a cationic to an anionic amphiphile intracellularly. This amphiphile performs two roles: first, it binds and then releases DNA, and second, as an anionic multicharged amphiphile, it destabilizes lipid bilayers. A charge-reversal amphiphile was synthesized and fully characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using these vectors compared to current cationic amphiphiles.
Cationic polymerization
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Abstract Ethyl α‐(hydroxymethyl)acrylate product: ethyl α‐(hydroxymethyl) acrylate product: ethyl α‐(bromomethyl)acrylate
Hydroxymethyl
Ethyl acrylate
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The title compound, C15H15NO4, which is a key intermediate in the synthesis of compounds used in organic light-emitting devices, has been synthesized by the reaction of 5-(chloromethyl)quinolin-8-ol hydrochloride with 2-hydroxyethyl acrylate. Molecules in the solid state are linked by O—H⋯N intermolecular hydrogen bonds to generate centrosymmetric dimers.
Ethyl acrylate
Meth-
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