Thiourea dioxide as a unique eco-friendly coreactant for luminol chemiluminescence in the sensitive detection of luminol, thiourea dioxide and cobalt ions
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Thiourea dioxide, a unique reductant that can generate oxygen upon decomposition, has been investigated as an efficient, cost-effective, and stable coreactant.Keywords:
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Development of novel high-sensitivity chemiluminescence assay for luminol using thiourea derivatives
We have screened about 100 thiourea derivatives in order to develop a sensitive chemiluminescence detection for luminol derivatives. Among these derivatives, we found a new compound, 2-(3-methylthioureido) thiazole, that could be used to measure luminol in the presence of hydrogen peroxide (H2O2). The detection limits of luminol and N-(4-aminobutyl)-N-ethylisoluminol (ABEI) were 10 fmol and 100 fmol, respectively. The mechanism of proposed chemiluminescence reaction was studied by electron spin resonance (ESR) with and without superoxide dismutase (SOD) and the addition of ethanol. The results showed that 2-(3-methylthioureido) thiazole has the ability to generate hydroxyl radical from H2O2, and produces intense chemiluminescence in the presence of luminol. The proposed novel chemiluminescence reaction for luminol and luminol derivatives was applied to a high performance liquid chromatography (HPLC) assay for amino compounds. Copyright © 1999 John Wiley & Sons, Ltd.
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Development of novel high-sensitivity chemiluminescence assay for luminol using thiourea derivatives
We have screened about 100 thiourea derivatives in order to develop a sensitive chemiluminescence detection for luminol derivatives. Among these derivatives, we found a new compound, 2-(3-methylthioureido) thiazole, that could be used to measure luminol in the presence of hydrogen peroxide (H2O2). The detection limits of luminol and N-(4-aminobutyl)-N-ethylisoluminol (ABEI) were 10 fmol and 100 fmol, respectively. The mechanism of proposed chemiluminescence reaction was studied by electron spin resonance (ESR) with and without superoxide dismutase (SOD) and the addition of ethanol. The results showed that 2-(3-methylthioureido) thiazole has the ability to generate hydroxyl radical from H2O2, and produces intense chemiluminescence in the presence of luminol. The proposed novel chemiluminescence reaction for luminol and luminol derivatives was applied to a high performance liquid chromatography (HPLC) assay for amino compounds. Copyright © 1999 John Wiley & Sons, Ltd.
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Thiourea dioxide, a unique reductant that can generate oxygen upon decomposition, has been investigated as an efficient, cost-effective, and stable coreactant.
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Abstract Ultrasonically induced chemiluminescence of luminol in an aqueous alkaline solution is described for the determination of cobalt(II). This novel method is capable of detecting cobalt(II) more sensitively than any other method with a detection limit of 0.07 pg and more selectively than any other chemiluminescence method.
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Uniquely, thiourea dioxide not only can reduce carbonyl compounds but also generate an oxidant to trigger luminol chemiluminescence. Herein, derivatization-free carbonyl compound detection using bifunctional chemiluminescence coreactant thiourea dioxide has been developed for the first time with the second most crucial flavor benzaldehyde as a representative.
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ルミノールは塩基性条件下，遷移金属イオンなどの触媒存在下で過酸化水素と反応し，6員環ペルオキシド中間体を経て2価のアミノフタル酸陰イオンの励起状態を生じ，これが基底状態となる際に発光すると考えられている．本研究では28種類のCo(III)錯体を合成し，ルミノールが過酸化水素と反応し化学発光する際の触媒作用について検討した．Co(III)錯体の構造に基づき五つのグループに分けて検討を行った．触媒作用の評価には，フローインジェクション分析法（FIA）を用いた．配位子の違いにより発光量に極めて大きな差異が認められた．検討した錯体の中で[Co(NO2)(NH3)5]Cl2及び[Co(CO3)(NH3)4]Clが顕著な触媒作用を示した．これら2種類のCo(III)錯体を用いて，FIAによる過酸化水素定量への応用を試みた．最適な検出条件を検討し，検出限界（S/N＝3）について調べた結果，[Co(NO2)(NH3)5]Cl2では0.2 nM（2 fmol），[Co(CO3)(NH3)4]Clでは5 nM（50 fmol）と高感度な値が得られた．検量線は，いずれのCo(III)錯体とも10 μMまで良好な直線性（r＞0.99）を示した．共存イオンの影響について検討し，実試料への適用を試みたところ河川水中の過酸化水素の測定が可能であった．
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The chemiluminescence reaction of luminol-hydrogen peroxide-cobalt (II) was studied using home-made instrument. As the instrument has been modified and the optimum conditions on the chemiluminescence reaction have been worked out. The sensitivety of the method was increased and the detection limit of cobalt is 7.4×10~(-3) g/mL. The linear range of the working curves is in 1×10~(-11)～1×10~(-7)g/mL Co (II). The variation coefficient is between 5.5% and 0.9% over the linear range of the working curves. The interference behaviors of 46 foreign ions have been examined. The means of eliminating interferences have been found. The method can be applied successfully to the determination of trace cobalt in water., blood, ores. The mechanism of the reaction was also investigated. It was proved that Co(II) is oxidized to Co (III) in the chemiluminescence reaction.
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