Evaluation of Genetic Susceptibility Loci for Chronic Hepatitis B in Chinese: Two Independent Case-Control Studies
Li WangXiaopan WuWei ZhangDahai ZhuYing WangYanping LiYao TianRongcheng LiZhuo LiXinlin ZhuJunhong LiJun CaiLi LiuXiaoping MiaoYing LiuHui Li
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Background A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world. Methods and Findings We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464–0.628, P = 4.068×10−16 and OR = 0.696, 95%CI: 0.601–0.806, P = 1.062×10−6, respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441–0.833, P = 0.002). Conclusion Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies.Keywords:
Hepatitis B
Chinese population
Han Chinese
Objective To investigate the vascular endothelial growth factor(VEGF) gene variations in the promoter region in Chinese Han population.Methods The polymorphisms of 300 Chinese Han healthy individuals from Northern China were analyzed using the method of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) or direct sequencing.The commercial statistics package SPPS11.5 was used to compare the distribution of the allele and the genotype,and to analyze their correlations with the data on European reported.Results Significant differences were observed between European and Chinese Han healthy individuals with regards to the frequencies of the genotype and allele for-2578C/A and-1154G/A(P 0.01) Conclusion The frequency of-2578A/A,-1154G/G genotypes in Chinese Han population is significantly lower than that in European.
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This study aims to investigate the difference of pelvic size and shape between Tibetan and Chinese Han women. Data on pelvic dimension measures including interspinous diameter (IS), intercrestal diameter (IC), external conjugate (EC) and transverse outlet (TO) were acquired from two population-based studies amongst Tibetan women in Lhasa, and Chinese Han women in Shaanxi province in China. After coarsened exact matching, there was no statistical difference between any characteristics amongst Tibetan and Chinese Han women (p>.05). The generalised estimating equation models showed Tibetan women had significantly lower IS and IC means than Chinese Han women (IS: 24.39 cm vs. 24.77 cm, p<.001; IC: 26.35 cm vs. 26.93 cm, p<.001) but statistically higher in TO mean (9.12 cm vs. 9.03 cm, p<.001). This study showed Tibetan women have smaller pelvis compared to Chinese Han women. This should offer a useful literature on the comparison of pelvis between Tibetan and Chinese Han women although the difference is small.Impact StatementWhat is already known on this subject? Previous studies in China indicated different populations have different dimensions of pelvis, with the pelvis of Uighur women being bigger than Chinese Han women, and that of Zhuang and Tu women being smaller than Chinese Han women. Little research reports the specific size of Tibetan women's pelvis. Living at high altitude, the Tibetan population have differentiated demographics and show local adaptions, such as unelevated haemoglobin, and significant catch-up growth for infants compared with Chinese Han infants. Therefore, there is a strong rationale for better understanding pelvic characteristics amongst this population.What the results of this study add? This study showed Tibetan women have smaller pelvises compared to Chinese Han women. Tibetan women have a smaller interspinous diameter and intercrestal diameter than Chinese Han women, which leads to relatively narrow hip.What the implications are of these findings for clinical practice and/or further research? This study provides useful comparative information on pelvic features between Tibetan and Chinese Han women although the findings of differences were small. In addition, during the formulation of women's health policy, the results of this study can provide data to support the selection of appropriate indicators of obstetrics and gynaecology for different populations of pregnant women during antenatal care and delivery.
Chinese population
Han Chinese
Demographics
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Objective To investigate distribution status of CYP450 2C19 genotype in Han healthy subjects in Jiangsu Province.Methods The CYP2C19 genotype of 81 Han healthy subjects were determined by the polymerase chain reaction-restriction fragment length polymorphism method(PCR-RFLP).Results The frequency of CYP2C19 homozygous extensive metabolisms(homEMs),heterozygous extensive metabolisms(hetEMs) and poor metabolisms(PMs) in the 81 Chinese subjects was 38.3%,45.7% and 16.0%,respectively.Conclusion The frequency of CYP2C19 poor metabolisms coincides with its frequency of Chinese population.
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ObjectiveTo determine the distribution of the single neucleutide polymorphisms (SNPs) of the vascular endothelial growth factor (VEGF) gene in Chinese Han population. Methods252 healthy Chinese Han subjects were studied with PCR technique. The results were compared with the data on European Caucasians reported. ResultsThe frequencies of VEGF gene allele C and A were respectively 71.8% and 28.2%. The genotypes of CC, CA and AA were 48.8%, 46.0% and 5.2%, respectively. The frequencies of VEGF promoter 2578A/A polymorphism in Chinese Han population were significantly different from those in European Caucasian population( P 0.01). Conclusion2578A/A homozygote which results to low VEGF expression of Chinese Han subjects is remarkably less than that of European Caucasians.
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POPULATION: Chinese Han and Thai.
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To investigate the distribution of Colton, Diego, Kell and Yt rare blood groups in Chinese Nanjing Han population, so as to improve the transfusion capability of patients with rare blood group and to further enrich the rare-blood-donor bank.A total of 2 015 blood samples from the blood donors were selected randomly to screen the presence of K⁺ and Kp(c+) (Kell), Yt(b+) (Yt), Co(b+) (Colton), Di(a+b+) and Di(a+b-) (Digeo) antigen allele by using PCR and multiplex PCR.Out of 2005 samples, 1 case with K⁺ gene, 8 cases with Yt(b+) gene and 100 cases with Di(a+b+) gene, 2 cases with Di(a+b-) were identified, while no Kp(c+) and Co(b+) were detected.The frequencies of K⁺, Yt(b+) and Di(a+), Di(b+) are 0.0003, 0.0013 and 0.0258, 0.9742, respectively. They are very rare blood groups in Chinese Nanjing Han population.
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Chinese population
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Objective To investigate thiopurine methyltransferase(TPMT) activity distribution in Chinese Han and Yao population. Methods TPMT activity of erythrocyte (RBC) in healthy subjects was measured by RP-HPLC method. Results The mean values of TPMT activity were (11.96±3.27)nmol·h~ -1·mL~ -1 packed RBC in 273 healthy Chinese Han adults, (13.02±2.78)nmol·h~ -1·mL~ -1 packed RBC in 88 healthy Chinese Han children, and(13.27±3.92)nmol·h~ -1·mL~ -1 packed RBC in 148 healthy Chinese Yao children, respectively. No subject had hardly detectable erythrocye TPMT activity. The frequency distribution histogram in Chinese Han and Chinese Yao children appeared to be normal. There was no statistically significant in TPMT acitvity between Chinese Yao children and Han children, and there was no gender differences in TPMT activity. There was no significant age-related differences in TPMT activity in the Chinese Han adults and Chinese Han children. However, TPMT activity correlated positively with age in Chinese Yao children with a small value of γ (γ= 0.2596). Conclusion The frequency distribtion of TPMT activity was unimodal in Chinese Han and Yao population.
Thiopurine methyltransferase
Han Chinese
Chinese population
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