PREMATURE LABOR TREATMENT WITH RITODRINE IN MULTIPLE PREGNANCY WITH THREE OR MORE FETUSES
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BIENIARZ, JOSEPH; SHAH, NIRANJANA; DMOWSKI, W PAUL; RAO, RAMAA; SCOMMEGNA, ANTONIO Author InformationKeywords:
Ritodrine
Premature labor
Treatment of preterm labor with beta-sympathomimetics has been questioned because of the many maternal and fetal complications associated with its use. Nifedipine, a calcium antagonist, has been shown to suppress uterine activity in vitro and in vivo. A randomized prospective study was performed to compare the efficacy of nifedipine to ritodrine in the suppression of preterm labor. Data obtained from 42 women, of which 19 were randomized to the ritodrine group and 23 to the nifedipine group, were analyzed. Ritodrine and nifedipine proved to be equally effective in the suppression of preterm labor. However, the nifedipine group had fewer maternal and fetal complications.
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Tocolytic agent
Premature labor
Preterm labour
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Tocolytic agent
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Beta-adrenergic agonists are commonly used to arrest premature labor. Although treatment of preterm labor with these agents can delay delivery by 24 to 48 hours, the potential risks and benefits to the mother and infant before and after delivery have not been adequately assessed.
Ritodrine
Premature labor
Adrenergic agonist
BETA (programming language)
Tocolytic agent
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Ritodrine
Premature labor
Tocolytic agent
Preterm labour
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Premature labor
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Tocolytic agent
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Ritodrine
Terbutaline
Premature labor
Preterm labour
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It is the thesis of the author that the use of Ritodrine in the treatment of premature labor is potentially dangerous and possibly even lethal. Ritodrine is being overused in the attempt to control and delay premature labor. Only 25 to 50 per cent of patients complaining of premature labor pains actually proceed to true preterm labor. Because there is no definitive screening test to firmly establish the diagnosis of preterm labor, many women are treated unnecessarily with a drug that many obstetricians question as to its efficacy, safety, and cost. If it is used, it must be in a hospital with adequate facilities both in manpower and the ability to identify and treat the medical and obstetrical complications. Ritodrine is too potentially dangerous to be used as an attempt to "do something" it there are questionable indications.
Ritodrine
Premature labor
Preterm labour
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Ritodrine
Tocolytic agent
Tocolytic
Preterm labour
Premature labor
Parotitis
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Two patients in premature labor were treated continuously for six and 13 weeks with intravenous magnesium sulfate (MgSO4) for tocolysis. In each case, conventional therapy with intravenous and oral ritodrine failed to abate uterine contractions, and attempts to taper the MgSO4 were unsuccessful. Both pregnancies proceeded uneventfully otherwise, with normal fetal growth. Long-term MgSO4 may be a safe and efficacious alternative for occasional patients not responding to other modes of therapy for the treatment of premature labor.(Obstet Gynecol 67:38S, 1986)
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Tocolytic agent
Premature labor
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