Combined use of ritodrine and magnesium sulfate for tocolysis of preterm labor
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Ritodrine
Premature labor
Tocolytic agent
Preterm labour
Treatment of preterm labor with beta-sympathomimetics has been questioned because of the many maternal and fetal complications associated with its use. Nifedipine, a calcium antagonist, has been shown to suppress uterine activity in vitro and in vivo. A randomized prospective study was performed to compare the efficacy of nifedipine to ritodrine in the suppression of preterm labor. Data obtained from 42 women, of which 19 were randomized to the ritodrine group and 23 to the nifedipine group, were analyzed. Ritodrine and nifedipine proved to be equally effective in the suppression of preterm labor. However, the nifedipine group had fewer maternal and fetal complications.
Ritodrine
Tocolytic agent
Premature labor
Preterm labour
Tocolytic
Sympathomimetics
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There is some controversy regarding the optimum duration of tocolysis. This retrospective multicentre study was performed to evaluate whether long-term (> 2 days) tocolysis is effective in treating threatened premature labour. A total of 1147 eligible patients were grouped according to whether or not tocolytics were given, and according to route of administration and whether or not ritodrine (the standard tocolytic regimen in Japan) or other tocolytic was given. They were then further stratified into three subgroups, using the Baumgarten and Gruber tocolysis index (TI), to assess the efficacy of tocolysis treatment according to the risk of premature labour. Prolongation of gestation was significantly longer in patients treated with tocolytics for > 2 days compared with the unmedicated, bed-rest group. In women receiving tocolysis, the mean duration of prolonged gestation was 2.2 times longer in the intermediate-risk TI group and 3.1 times longer in the high-risk TI group compared with the unmedicated group. In the patients who received tocolysis, IV ritodrine was used in 86% of cases and was considered safe and effective for prolonging gestation in cases of threatened premature labour.
Ritodrine
Tocolytic agent
Preterm labour
Regimen
Premature labor
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Uterine hypertonia with severe fetal distress occurred during maternal seizures in labor. The administration of ritodrine resulted in quick relaxation of the uterus and recovery of the compromised fetus.
Ritodrine
Premature labor
Tocolytic agent
Preterm labour
Obstetric labor complication
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Premature labor
Tocolytic agent
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Premature labor
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Tocolytic agent
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Tocolytic agent
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Tocolytic agent
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Tocolytic agent
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