Dramatic effect of homoallylic substitution on the rate of palladium-catalyzed diene cycloisomerization
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A gold-catalysed cycloisomerization of 1,5-diynes is described, which offers a selective approach to access 1,3,4-trisubstituted pyrroles.
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Abstract A protocol for the Au‐catalyzed cycloisomerization of boronated enynes is developed.
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Gold-catalyzed cycloisomerization of 1,5-enynes has been investigated with the aid of density functional theory calculations at the B3LYP level of theory. We have examined how substituents influence the reaction paths in the cycloisomerization of 1,5-enynes catalyzed by both AuCl and [AuL]+ (L = phosphine).
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An efficient synthetic method to prepare architecturally challenging spiro tetrahydro‐3 H ‐dicyclopenta[ a,b ]naphthalene derivatives from Au(I)‐catalyzed intramolecular sequential cycloisomerization of linear 1,3,9‐ene‐allene‐ynes is described. The proposed cycloisomerization pathway involves an initial gold‐catalyzed 1,3‐ene‐allene cycloisomerization, followed by a formal [4+2] cycloaddition to give fused spirocarbocyclic products containing a quaternary centre.
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This chapter contains sections titled: Introduction Cycloisomerization of CO onto CCC Cycloisomerization of CO onto CC Cycloisomerization of CN onto CCC Cycloisomerization of CN onto CC Ene–Yne Cycloisomerization: CC onto CC Other Transformations Conclusion References
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Abstract The reaction conditions developed for the cycloisomerization of various 2‐ethinylbiaryls to phenanthrenes are also applied in the cycloisomerization of heteroaryl analogues.
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