Spontaneous Ocular Squamous Cell Carcinoma in Twin Goats: Pathological and Biomolecular Studies
M. MaràGiovanni Di GuardoAldo VenutiGiuseppe MarruchellaChiara PalmieriM. De RugeriisLucio PetrizziPaola SimeoneConsuelo RizzoLeonardo Della Salda
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Etiology
Bovine papillomavirus
Parenchyma
Papillomaviridae
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Koilocyte
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Mann D.M.A., Davies J.S., Hawkes J. & Yates P.O. (1982) Neuropathology and Applied Neurobiology 8, 55–61 Immunohistochemieal staining of senile plaques Immunohistochemical staining of serum proteins, including immunoglobulins, was carried out on formalin‐fixed cerebral tissue from 24 autopsy cases (twenty dements, four controls) and fifteen biopsy cases (ten dements, five controls). Sixteen of the autopsy cases showed focal regions where there was staining of globulins and other serum proteins within senile plaque ‘cores’, nerve cell perikarya and astrocytes. This pattern of staining, generally, occurred either in relation to areas of cerebral infarction or in the neighbourhood of small arteries displaying arteriosclerotic changes. In tissue areas, distant from these vascular alterations, no staining occurred. Furthermore, none of the biopsy cases showed any such areas of staining. These findings indicate that the positive immunohistochemical reactions demonstrated within senile plaques (and other tissue components) are more likely to result from leakage of serum proteins, including immunoglobulins out of damaged vessels and into the brain parenchyma, rather than being indicative of the involvement of immunological mechanisms in the aetiology of plaques, as has been suggested by other workers.
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Squamous cell carcinomas (SCCs) usually show a standard histopathologic picture only varying with regard to their degree of differentiation. The authors describe a case of clear cell SCC that was studied by light and electron microscopy. The clear cells showed an empty cytoplasm that was periodic acid‐Schiff and alcian blue negative. By electron microscopy these cytoplasms consisted of empty spaces and were not surrounded by membranes, which would be consistent with lipid vacuoles. The differential diagnosis of this uncommon variant of SCC requires consideration of other clear cell tumors.
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Papillomaviruses have been reported to be very difficult to grow in cell culture.Also, there are no descriptions of cell cultures from lesions of bovine cutaneous papillomatosis, with identification of different bovine papilloma virus (BPV) DNA se-different bovine papilloma virus (BPV) DNA sequences.In the present report, we describe primary cell cultures
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Objective To investigate the diagnosis and differential diagnosis of sclerosing hemangioma of the lung(SHL).Method Detailed pathologic observations were conducted on 8 cases of SHL,with particular attention upon theirsecondary pathological changes.Results SHL usually occured in female patientsof middle or young ages,and mostly located at the peripheral region of middle or right lobes.Under microscope,the basic pathological changes were irregularly distributed clefts and papillary structures in parenchyma areas of tumor cells.Secondary changes were usually presented,such as hemorrhage,chronic inflammatory cells infiltration,foamy cells accumulation,hyaline change of small blood vessels and fibrosis.Misdiagnosis was easily made because of these secondary changes.Conclusion Discovery of parenchyma areas of tumor cells was the key point of SHL diagnosis when secondary pathological changes were marked.
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Objective To detect the clinicopathological significance of p16 and p53 gene expression in oral squamous cell carcinomas. Methods The expression of P16 and P53 were examined in 31 cases of squamous cell carcinomas with immunohistochemical techniques. Results The positive staining of P16 appeared in cell nuclei and cytoplasmas, while P53 appeared only in cell nuclei. The positive rate of P16 expression was 54.8%(13/17). 16 of 31(51.6%) samples expressed P53 protein, among which, squamous cell carcinoma grade Ⅰ was 45.5%(10/12), grade Ⅱ 33.3%(1/3), grade Ⅲ～Ⅳ 83.3%(5/6), and there was a significant difference between grade Ⅰ and grade Ⅲ～Ⅳ. Conclusion There was no correlation between the expression of p16 and p53 genes, so further studies examining mechanisms of p16 in activation are needed to clarify the relationship between p16 and p53 in oral squamous cell carcinoma.
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The literature on the etiology, pathogenesis, clinical manifestations and pathology, basic approaches to the treatment of congenital and acquired pathological deformation of the internal carotid artery has been analyzed. The review discusses the possible risk factors and diseases that lead to the development of pathological deformations as well as existing hypotheses of pathogenesis. Open and unresolved issues of the etiology and pathogenesis of this disease are identified. The disputable issues on the emergence and development of vascular deformations in children, young people and elderly are discussed. The authors posit a hypothesis that congenital and acquired pathological deformations are different diseases which differ by etiology, pathogenesis, clinical and pathomorphological picture, prognosis, approaches to diagnosis and treatment; the relationship between them has not been proved.Проведен обзор литературы по вопросам этиологии, патогенеза, клиническим и патоморфологическим проявлениям и основным подходам к лечению врожденных и приобретенных патологических деформаций внутренней сонной артерии. Рассмотрены возможные факторы риска и заболевания, приводящие к развитию патологических деформаций, существующие гипотезы патогенеза. Выявлены открытые и неразрешенные вопросы этиологии и патогенеза данной патологии. Обсуждаются дискутабельные вопросы возникновения и развития деформаций сосудов у детей, в молодом и старшем возрасте. Выдвинуто предположение, что врожденные и приобретенные патологические деформации - это разные заболевания с отличающимися этиологией, патогенезом, клинической и патоморфологической картиной, прогнозом, подходами к диагностике и лечению, связь между которыми не доказана.
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扁平上皮癌はお互いに類似性をもっているが, 相違する所見が分化度によって様々である。口腔扁平上皮癌の悪性度による超微構造は多くの研究者により報告されている。超微構造に関する研究では高分化型扁平上皮癌と低分化型扁平上皮癌との間に明確な相違があることが報告されている。発癌を含む増殖障害は細胞増殖の増加率としばしば関係している。過去20ないし30年にわたり, ヒト悪性腫瘍の組織学的悪性度および腫瘍態度の指標として細胞増殖マーカーが注目されている。高倍率の視野での核分裂像数が口腔扁平上皮癌の分化度の判定のための形態学的所見の一つである。口腔腫瘍のラベリング・インデックス由来のPCNAやKi-67を含む細胞周期抗原の免疫組織学的マーカーを用いて多くの研究が報告されている。増殖能の意義はアポトーシスへ向かう細胞の数による。増殖能とアポトーシスのバランスの不一致が腫瘍発生に関係している。p53は癌抑制遺伝子としてよく知られており, 不必要な細胞のアポトーシスを誘導することができる, 変異型p53によるアポトーシスの回避は悪性腫瘍の発生に関係している。多くの研究は口腔癌の細胞増殖とp53の過剰発現と相関があることを報告している。本総説は扁平上皮癌の病理組織学的悪性度と超微構造的所見, 細胞増殖, アポトーシス関連遺伝子との関連について述べる。
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