The Comorbidity of Diabetes Mellitus and Depression
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The results of treatment of 103 patients with tuberculosis and non-specific diseases of the lungs with concomitant diabetes mellitus were analysed. The main principles of preoperative preparation and postoperative management of the patients are presented. The incidence of operative complications was 10.7%, postoperative--17.5%, mortality--2.9%. The clinical effect was achieved in 97.1% of patients. Reactivation of tuberculosis after operation was noted in 7.8% of patients.
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Background and Purpose: Obesity and depression are highly comorbid and far from effective treating. Celastrol was reported useful for obesity, but its role in the obesity-depression comorbidity remains unknown. This study aims to investigate the efficacy and associated mechanism of celastrol in this comorbidity.
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We identify a representative sample of US diabetes patients with comorbid hypertension and obesity and then evaluate health-care expenditures in this population across comorbidity categories. The underlying hypothesis is that the presence of comorbid obesity and hypertension poses an additional burden on patients with diabetes, thus impacting their overall resource utilization. More than one-third of diabetes patients suffer from comorbid obesity and hypertension, which outnumbers diabetes patients with neither or only one of these comorbidities. The results of multivariate regressions clearly show the significant impact these comorbidities have on the health-care expenditures of the diabetes population. For example, a person with diabetes and obesity has health-care expenditures 14% greater than a diabetes patient without obesity. Adding hypertension to a diabetes patient raises health-care expenditures by 26%. Finally, diabetes patients with both comorbid obesity and hypertension – the fastest growing group of diabetes patients – have health-care expenditures 40% higher than those without these comorbidities. Our results indicate that diabetes patients are placing an increasing strain on health-care resources, and health-care providers should consider the management of comorbid hypertension and/or obesity, as these have significant effects on resource utilization and expenditures beyond the underlying diabetes condition.
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Hypertension frequently coexists with obesity, diabetes, hyperlipidemia, or metabolic syndrome, anditsassociation with cardiovascular disease is well established. The identification and management of these risk factors is an important part of overall patient management. In this paper, we find the most relevant patterns of hospitalized patients with cardiovascular diseases, consideringaspects of their comorbidities, such as triglycerides, cholesterol, diabetes, hypertension, and obesity. To find the most relevant patterns, several clusterizations were made, playing with the dimensions of comorbidity and the number of clusters. There are three main patient types who require hospitalization: 20% whose comorbidities are not so severe, 44% with quite severe comorbidities, and 36% with fairly good triglycerides, cholesterol, and diabetes but quite severe hypertension and obesity. The comorbidities, such as triglycerides, cholesterol, diabetes, hypertension, and obesity, were observed in different combinations in patients upon hospital admission.
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Background Diabetic dermopathy is the most common cutaneous marker of diabetes mellitus. The relationship of diabetic dermopathy to internal complications of diabetes mellitus, such as nephropathy, retinopathy, and neuropathy, is still unknown. Methods The possible role of diabetic dermopathy as a clinical sign of internal complications in diabetes mellitus was investigated. One hundred and seventy‐three patients with diabetes mellitus, of whom 125 (72%) had insulin‐dependent diabetes mellitus and 48 (28%) had non‐insulin‐dependent diabetes mellitus, were studied. Results Diabetic dermopathy was present in 69 (40%) of patients, statistically more significant in patients 50 years of age and older. The mean diabetic duration was significantly higher in patients with diabetic dermopathy than in those without. The associations of diabetic dermopathy with retinopathy, nephropathy, and neuropathy were each statistically significant, and the increased frequency of diabetic dermopathy correlated with an increased number of these three complications in each patient. Conclusions Some of the factors that affect the development of internal complications in diabetes mellitus may play a role in the development of diabetic dermopathy, and diabetic dermopathy may serve as a clinical sign of an increased likelihood of these internal complications in diabetic patients.
Diabetic Neuropathy
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Objective: To define the extent of comorbidity in depression. Method: The level of medical comorbidity in depression was assessed on the basis of the empirical literature and results from the National Institute of Mental Health (NIMH) conference on Depression's Toll on Other Illnesses. Results: The global incidence of depression underscores the need to develop integrative treatment strategies for these disorders. An NIMH conference entitled ‘The Unwanted Cotraveler: Depression's Toll on Other Illnesses' has highlighted the impact of increased depression prevalence in the presence of medical disorders. Economic data from a large health insurance claims database concludes that the presence of a psychiatric condition, particularly depression, considerably increases the medical costs, as well as the cost of caring for the psychiatric condition. Conclusion: Federally sponsored research intervention centres need to address these issues and provide opportunities for diverse medical specialties to collaborate on testing novel treatment approaches.
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Obesity and depression represent two fundamental problems of public health at a global level; paediatric obesity is alarming both per se and through the risk of maintaining the obese status in adulthood and of continuing to be exposed to comorbidity, implicitly. On the other hand, depression in children is a genuine diagnostic problem (considering its masked clinical symptomatology) and a diagnostic necessity (considering its severe consequences and mostly the pathological alterations of food-related behaviour). This paper seeks to elaborate a synthesis of the current scientific literature regarding the causes of obesity – depression comorbidities in children, with a focus on the interrelation and common etiopathogenic origin.
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Depression
Sedentary lifestyle
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