Evoked potential changes in clinically definite multiple sclerosis: a two year follow up study.
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Visual, spinal and somatosensory evoked potentials were performed on 56 patients with clinically definite multiple sclerosis at the beginning and end of a 2 1/2 year follow-up period. At the initial examination one or both visual evoked potentials were abnormal in all but nine patients (84%), five of whom had abnormalities of either spinal or somatosensory evoked responses; that is, one or more abnormal results were obtained from 52 of 56 (91%) patients. At the final examination there were abnormalities of one or more evoked potentials in 55 of the 56 (98%) patients. There was an increase in latency of the components of the evoked responses over the period; reduction in latency in individual patients was exceptional. The change in these electrophysiological measurements correlated with the increase in clinical disability of the group of patients over the period of study.Keywords:
Somatosensory evoked potential
Evoked potential
Visual evoked potentials
Evoked potential
Somatosensory evoked potential
Visual evoked potentials
Electroretinography
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Somatosensory evoked potential
Evoked potential
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Somatosensory evoked potential
Evoked potential
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Somatosensory evoked potential
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Somatosensory evoked potential
Evoked potential
Visual evoked potentials
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Intraoperative neurophysiologic monitoring (IONM), including somatosensory evoked potential (SEP), and transcranial electric motor evoked potential (MEP), had been utilized during brain or spine surgery to identify neurologic deficits. But some neurologic deficits, such as abulia, could not be detected through routine IONM. MEP or SEP might not monitor non-motor or sensory lesions during surgery. We experienced a 72-year-old case with an anterior communicating aneurysm who experienced abulia after surgery even though routine IONM was performed. There was no abnormality on IONM during aneurysm clipping surgery, but she turned into an abulic state. This case alerts us to the possibility that monitoring failure could occur despite standard IONM procedures using MEP and SEP.
Somatosensory evoked potential
Evoked potential
Clipping (morphology)
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The long-term effects for the neural activities on somatosensory area caused by transcranial direct current stimulation (tDCS) have been showed with somatosensory evoked potentials (SEPs) and high frequency oscillations (HFOs) in animals and humans. This study investigates the relationship of SEPs with HFOs before and after applying cathodal tDCS (0, 15, 30, 45, 60 min) to human left somatosensory cortex for 15 min at 2 mA. The amplitudes of N20 and P30 evoked by right median nerve stimulation were slightly decreased after cathodal tDCS. Likewise, HFOs were affected by cathodal tDCS but there weren't steadily decrement during the entire HFO, the effects were oscillating depending on the peak of HFOs or the elapse time after tDCS. tDCS may leave the different influences between time- and location-dependent somatosensory processing.
Somatosensory evoked potential
Transcranial Direct Current Stimulation
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Somatosensory evoked potentials (SEPs) reflect the activity of somatosensory pathways mediated through the dorsal columns of the spinal cord and the specific somatosensory cortex. In this study we aimed to demonstrate the effects of physiologic parameters such as height, age and gender on N9, N13, N20 SEP components and the central conduction time (CCT) to median nerve stimulation in Turkish population. The results revealed a statistically significant correlation between height, gender and SEP latencies (p < 0.05 and p < 0.0005 respectively) whereas no significant age related changes was found in SEPs. In all groups CCT was not influenced by these parameters.
Somatosensory evoked potential
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Objective Intraoperative electrophysiological monitoring is gaining a wider application in spinal surgery.The present article is to explore the application value of somatosensory evoked potential(SEP) and motor evoked potential(MEP) in spinal surgery.Methods We employed both SEP and MEP for dynamic monitoring of 7 cases of spinal surgery,and adopted SEP alone for another 3.Results SEP was successfully induced and recorded in all the cases,while MEP only in 3 cases.Compared with preoperative forewarning potential,the wave amplitude of SEP was decreased during intraoperative monitoring in 2 cases,but restored to normal after the operation was stopped or the surgical methods adjusted.One case showed obviously improved symptoms after surgery though with an increased wave amplitude of SEP during intraoperative monitoring.No significant changes were observed in either amplitude or latency of the wave in the 3 cases with MEP recorded.Conclusion Evoked potential monitoring,especially with combined SEP and MEP during spinal surgery,can effectively reduce mechanical damage to nerves,increase the success rate of resection,and raise the confidence of the surgeons.
Somatosensory evoked potential
Spinal Surgery
Evoked potential
Intraoperative neurophysiological monitoring
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Visual, spinal and somatosensory evoked potentials were performed on 56 patients with clinically definite multiple sclerosis at the beginning and end of a 2 1/2 year follow-up period. At the initial examination one or both visual evoked potentials were abnormal in all but nine patients (84%), five of whom had abnormalities of either spinal or somatosensory evoked responses; that is, one or more abnormal results were obtained from 52 of 56 (91%) patients. At the final examination there were abnormalities of one or more evoked potentials in 55 of the 56 (98%) patients. There was an increase in latency of the components of the evoked responses over the period; reduction in latency in individual patients was exceptional. The change in these electrophysiological measurements correlated with the increase in clinical disability of the group of patients over the period of study.
Somatosensory evoked potential
Evoked potential
Visual evoked potentials
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Citations (60)