Pregnancy: Cytogenetic characteristics of ectopic pregnancy
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Abstract:
During a 12 month period, tissue was collected from 30 surgically managed patients presenting with vital ectopic pregnancies. Chorionic villi of the removed tissue were successfully karyotyped by (semi-) direct chromosome technique in 22 cases. Only one abnormal chromosomal complement, a triploidy (69,XXX) was found. As controls, 10 cases of intrauterine pregnancies were investigated, all showing a normal karyotype. These findings do not suggest an important role for chromosome abnormalities in the aetiology of vital ectopic pregnancies.Keywords:
Chorionic villi
Etiology
Chromosomal analysis
Overdiagnosis
Early Pregnancy Loss
Early pregnancy factor
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Chromosome analysis of blood culture and bone marrow mitoses from a patient with chronic myeologenous leukaemia revealed a Ph 1 ‐positive cell‐line with 45 chromosomes and, later, a series of mutually related lines with 50–53 chromosomes including Ph 1 . The cell‐line with 45 chromosomes was sensitive to therapy, whereas the cells with 50–53 chromosomes seemed to be more or less resistant to the applied drugs. This apparent resistance suggests that these lines may have contributed to the haematologically and clinically poor condition of the patient at the time of their observation. The close relationship among the hyperdiploid cell lines suggests a common origin and gradual evolution of the lines on a selectional basis.
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Problems in early pregnancy are among the most common conditions in gynecology and - with management becoming less invasive and depending more on accurate ultrasound and a good understanding of serum biochemistry - many countries now recommend that all maternity units have an early pregnancy section dedicated to managing these conditions. In additi
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The purpose of this paper was to evaluate the reproductive outcome after ectopic pregnancy (EP) from a population-based register in the centre of France. Since 1992, all the women aged 15–44 years, who permanently reside in the target area and who were treated either by surgical or medical procedures for an ectopic pregnancy in one of the area centres, have been registered and prospectively followed until 45 years of age. The analysis presented was based on the 155 women registered between January 1992 and March 1994 who were followed up for at least 6 months, and who were seeking a new pregnancy. The mean follow-up period was 16 months. A total of 102 women (66%) obtained a pregnancy. The first conception was intrauterine for 92 women, and 10 had a recurrence of ectopic pregnancy. Risk factors of recurrence were prior spontaneous abortion and prior tubal damage. For those women who conceived, the mean time to obtain pregnancy (’time to pregnancy‘) was 4.8 months. The 1 year cumulative intrauterine pregnancy rate (i.e. the probability of obtaining an intrauterine pregnancy within 1 year of seeking pregnancy) was 70%. After multivariate analysis by a Cox regression, the factors associated with higher fertility were age < 30 years, high educational level and no prior tubal damage.
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Cytogenetics is the diagnostic study of chromosomal structure and properties, as well as cell division, using a variety of methods, one of which is “karyotyping.” It refers to a method of photographing a stained preparation in which the chromosomes are organised in a uniform pattern. The advent of modern techniques such as “karyotyping” has made it feasible to visualize undetected chromosomal abnormalities such as short chromosome segments and chromosome translocations. Because such techniques enabled each pair of chromosomes to be identified separately, they have further aided our understanding of the chromosomal basis of a certain significant genetic diseases. Every organism has its own unique karyotype, which is defined by its number and shape. Karyotypic variation, on the other hand, occurs in different individuals of the same species, as well as between different species. Monitoring cytogenetic data of economically significant fishes as well as threatened fishes can hold importance of the succeeding generations. This review article highlights the variation in the chromosomal number & classification, methods of chromosome preparation and karyotypic analysis of various fish species of India with a special reference to fishes of Kashmir Himalayas.
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Objective Cytogenetics method was analysed in Mongolian idiocy and the reason which induce the disease.Methods The method of cytogenetics as cell culture,plate,making,G banking and karyotype analysis ect,has been adopted in the cytogeneties study of patient's chromosome of pripheral blood lymphocyte.Result It was found that the karyotype of 21 patients were abnormal,including 18 ease of standard type,and2 case of translocation type,and 1 case of mosaic type.Conclusion:The cytogenetic technology is an use- ful method to diagnose chromosome abnormality-related disease Down syndrome is relation to mother~ age,genetics,enviroment,ect, factors and other.
Chromosome analysis
Abnormality
Chromosomal analysis
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Chromosome abnormality
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Objective:Analysis of 74 cases of adult acute leukemia patients with chromosome abnormalities and the distribution of subtypes of karyotype changes in characteristics.Method:On the preliminary diagnosis of acute leukemia morphology,immunology,cytogenetics,molecular biology testing.Result:Chromosomal abnormalities in patients with acute leukemia karyotype in AML,ALL was respectively,64.4%(38/59)and 73.3%(11/15),with an average chromosome abnormalities accounted for 66.2%(49/74).Chromosome abnormalities from the view of the characteristics,M3 more consistent chromosomal change according to t(15;17)(q22;q11.2)changes in the main;while other types of leukemia,there was inconsistency chromosomal abnormalities,especially in M4 there was a clear inconsistent.Conclusion:Acute leukemia according to analysis of chromosomal abnormalities,complex karyotype is a sign of poor prognosis.Some of the specific chromosomal abnormalities and the FAB subtypes closely related.Therefore,the chromosomal abnormality karyotype analysis in leukemia diagnosis,classification,treatment and prognosis aspects play an important role.
Abnormality
Chromosomal analysis
Chromosome abnormality
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During a 12 month period, tissue was collected from 30 surgically managed patients presenting with vital ectopic pregnancies. Chorionic villi of the removed tissue were successfully karyotyped by (semi-) direct chromosome technique in 22 cases. Only one abnormal chromosomal complement, a triploidy (69,XXX) was found. As controls, 10 cases of intrauterine pregnancies were investigated, all showing a normal karyotype. These findings do not suggest an important role for chromosome abnormalities in the aetiology of vital ectopic pregnancies.
Chorionic villi
Etiology
Chromosomal analysis
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Abstract Prenatal diagnosis on chorionic villous tissue was performed for a woman with the karyotype 46,XX,t(2;18)(q32;q12)—a subtle ‘difficult’ translocation. The case illustrates the necessity of good quality cytogenetics for accurate prenatal diagnosis. For chorionic villi this can be obtained only with long‐term culture.
Chorionic villus sampling
Chorionic villi
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