Which kind of transition is important for sound representation? An event-related potential study
17
Citation
70
Reference
10
Related Paper
Citation Trend
Keywords:
Auditory event
Sensory memory
A new faster paradigm to measure the duration of auditory sensory memory, as indexed by mismatch negativity (MMN) suppression to stimuli presented at increasing inter-stimulus intervals (ISI), is proposed. Trains of three stimuli were delivered at very short ISI (300 ms). The inter-train interval varied according to the memory probe interval (MPI) tested. Trains started randomly with a deviant or standard stimulus (50% each), with their event-related brain potentials subtracted to obtain the MMN. The new paradigm provided MMNs identical to the conventional one at MPIs of 0.4 and 4.0 s in young subjects, and revealed MMN suppression when the MPI was increased to 5.0 s in older subjects. The new paradigm estimates auditory sensory memory duration in one-third the time of conventional MMN.
Sensory memory
Stimulus (psychology)
Echoic memory
Engram
Cite
Citations (57)
Mismatch negativity (MMN) is an event-related potential that is elicited by deviant sounds that are presented along with frequent sounds in the absence of attention. Auditory MMN is generated by the comparison process between sensory memory trace of a frequent auditory event and a deviant event. It is well known that frequent sounds are encoded in memory trace and processed as a single unit within 160-170 ms. This study examined whether deviant sound would be similarly processed as a temporal unit. Twelve healthy men were presented with relatively short standard sounds and relatively long deviant sounds that contained an omitted (i.e. silent) part. Three types of deviant sounds were designed to vary in duration. The MMN amplitude was gradually enhanced from the short to long duration deviant events that contained an omitted part. In contrast, MMN latency showed no significant differences among the deviants. These findings show that deviant sounds are also processed as a unitary event.
Sensory memory
Engram
Echoic memory
Auditory event
Contingent negative variation
Cite
Citations (7)
Event Abstract Back to Event Mismatch Negativity in Autism Spectrum Disorder Ulrich Schall1, 2*, Benjamin Weismueller3, 4, Renate Thienel2, 3, Anne-Marie Youlden5 and Ross Fulham3 1 University of Newcastle, PRC Translational Neuroscience & Mental Health Research, Australia 2 Schizophrenia Research Institute, Australia 3 University of Newcastle, Australia 4 University of Bremen, Germany 5 Educare, Australia Background: Growing evidence suggests impaired low-level sound processing in Autism Spectrum Disorders (ASD). Mismatch Negativity (MMN) represents a psychophysiological measure of low-level sound processing in primary auditory cortex. A reduction of the MMN event-related potential has been repeatedly reported in children diagnosed with ASD. However, previous studies did not sufficiently take into account developmental changes in sensory processing of auditory information. We hypothesized that the ability to process complex auditory information improves with brain development but not in ASD. Methods: Study participants were 18 boys aged between 6 to 15 years meeting DSM-IV ASD criteria. Data were compared to 15 age-matched healthy boys. All study participants were neuropsychologically assessed including IQ (Wechsler Abbreviated Scale of Intelligence). MMN was recorded in response to pitch, intensity, and stimulus duration deviance as well as in response to complex sounds (i.e. phonemes). Results: ASD children presented with lower IQ and impaired performance in verbal fluency and social cognition. Verbal fluency performance significantly correlated with MMN amplitudes in response to phoneme deviants. A strong differential association of MMN with age depending on stimulus complexity was equally found in both groups. Conclusion: These findings suggest that MMN captures brain maturation of low-level auditory information in 6 to 15 year old boys but does not discriminate children with ASD from their healthy counterparts despite ASD children were presenting with poor verbal fluency, lower IQ, and impaired social cognition. Keywords: mismatch negativity, brain maturation, verbal fluency, Austism, phonems Conference: XII International Conference on Cognitive Neuroscience (ICON-XII), Brisbane, Queensland, Australia, 27 Jul - 31 Jul, 2014. Presentation Type: Poster Topic: Cognition and Executive Processes Citation: Schall U, Weismueller B, Thienel R, Youlden A and Fulham R (2015). Mismatch Negativity in Autism Spectrum Disorder. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). doi: 10.3389/conf.fnhum.2015.217.00387 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Feb 2015; Published Online: 24 Apr 2015. * Correspondence: Prof. Ulrich Schall, University of Newcastle, PRC Translational Neuroscience & Mental Health Research, Newcastle, Australia, Ulrich.schall@newcastle.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ulrich Schall Benjamin Weismueller Renate Thienel Anne-Marie Youlden Ross Fulham Google Ulrich Schall Benjamin Weismueller Renate Thienel Anne-Marie Youlden Ross Fulham Google Scholar Ulrich Schall Benjamin Weismueller Renate Thienel Anne-Marie Youlden Ross Fulham PubMed Ulrich Schall Benjamin Weismueller Renate Thienel Anne-Marie Youlden Ross Fulham Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
Auditory event
Sensory memory
Stimulus (psychology)
Cite
Citations (0)
Echoic memory
Sensory memory
Auditory event
Cite
Citations (0)
The N1, P2, and P3 event-related potentials (ERPs) are impaired in first-episode schizophrenia (FESz). Reduced pitch-deviant mismatch negativity (MMN) is present in chronic schizophrenia but not FESz. We examined effect sizes of, and correlations between, N1, P2, P3, and MMN in 106 FESz and 114 matched psychiatrically well controls to determine which ERPs maximally differentiated groups, and whether late sensory/perceptual deficits (N1, P2) affected preattentive memory (MMN) and conscious attention (P3). Furthermore, we compared hallucinators and nonhallucinators within FESz. Participants completed 1 of 3 oddball tasks, silently counting target tones among standard tones. Sixty-seven FESz and 72 matched participants also completed pitch-deviant MMN testing. Measures were z-scored from task appropriate controls before merging samples. Mean z-scores for N1, P2, and P3 were significantly abnormal in FESz, while pitch-deviant MMN was not. N1 showed the largest deficit (z = 0.53), and only N1 was smaller in hallucinators (n = 71) than nonhallucinators (n = 27). Among all participants, early sensory processing (N1, P2) correlated with later cognitive processing (P3), and P2 and P3 also correlated with automatic preattentive memory (pitch-deviant MMN). In well individuals, N1 was associated with MMN. These data are consistent with bottom-up sensory/perceptual processes affecting more cognitive processes. However, N1 and MMN were not associated in FESz, suggesting different auditory cortex physiology underlie these ERPs, which is differentially affected in FESz. Larger P2 and P3 with greater estimated premorbid intellect in patients indicate a possible neuroprotective effect of intellect in FESz.
Schizophrenia Spectrum
Auditory event
Cite
Citations (15)
An event-related brain potential (ERP) component called mismatch negativity (MMN) is elicited by physically deviant auditory stimuli presented among repetitive, "standard," stimuli. MMN reflects a mismatch process between sensory input from the deviant stimulus and a shortduration neuronal representation developed by the standard stimulus. The MMN amplitude is known to correlate with pitch-discrimination performance. The purpose of the present study was to investigate whether the MMN is different in absolute pitch (AP) possessors and nonpossessors. ERPs were recorded from AP and non-AP groups, which were matched with regard to musical training. It was found that deviant stimuli differing from standard tones by a quartertone or a semitone elicited an MMN irrespective of whether the stimulus was located on (white key/black key) or off the Western musical scale. These results were obtained with both sinusoidal and piano tones. The MMN was larger and earlier when the stimuli were piano tones than when they were sinusoidal tones and when the standard-deviant difference amounted to a semitone rather than a quartertone. However, differences between the groups were not found in auditory information processing reflected by the MMN component of the ERP. In the light of the earlier MMN results showing a close correlation between the MMN and pitch- discrimination accuracy, it might be concluded that pitch discrimination and identification are based on different brain mechanisms. In addition, the differences in the MMN amplitude and latency between sinusoidal and piano tones might be interpreted as suggesting that sensory memory traces, as reflected by the MMN, are capable of storing information of very complex sound structures also.
Sensory memory
Semitone
Stimulus (psychology)
Auditory event
P3a
Absolute pitch
Cite
Citations (50)
The mismatch negativity (MMN) is a frontal negative deflection in the human event-related potential that typically occurs when a repeating auditory stimulus changes in some manner. The MMN can be elicited by many kinds of stimulus change, varying from simple changes in a single stimulus feature to abstract changes in the relationship between stimuli. The main intracerebral sources for the MMN are located in the auditory cortices of the temporal lobe. Since it occurs whether or not stimuli are being attended, the MMN represents an automatic cerebral process for detecting change. The MMN is clinically helpful in terms of demonstrating disordered sensory processing or disordered memory in groups of patients. Improvements in the techniques for measuring the MMN and in the paradigms for eliciting it will be needed before the MMN can become clinically useful as an objective measurement of such disorders in individual patients.
Sensory memory
Stimulus (psychology)
Engram
Cite
Citations (580)
In adults, deviant sounds occurring among repetitive standard sounds elicit the mismatch negativity (MMN) component of auditory event‐related brain potential (ERP) even when these sounds are not attended to. MMN appears to be generated in the auditory cortex by a comparison process between deviant auditory input and a neuronal sensory‐memory trace that is formed by the repetitive standard stimuli and which represents their physical features. Recent ERP studies have shown that MMN is also elicited in newborns and in older infants by physical changes in simple tones, as well as by changes in phonemes. Thus, MMN might provide a new tool for objective assessment of normal and deficient development of auditory discrimination, sensory memory, and speech perception in infants.
Sensory memory
Echoic memory
Engram
Auditory perception
Auditory event
Cite
Citations (26)
Mismatch negativity (MMN) of the event related potential (ERP) is generated when patients can discriminate two different kinds of stimuli even if he or she is not conscious of their differences. The authors examined auditory ERPs of passive paradigm in 16 patients with severe multiple handicaps. All patients showed no or scarce clinical response to human voices or environmental sounds. This study investigated whether they showed MMN, since it is hard to evaluate their auditory perception clinically. Auditory stimuli were the tone bursts of 700 and 1,000 Hz in frequency offered at a 4:1 occurrence. Nine of 16 patients showed a definite N2 wave followed by an N 1 wave. The latency of the N 2 wave ranged from 150 to 596 milliseconds after the onset of the target stimuli. This N 2 was considered compatible with mismatch negativity (MMN) in healthy patients. These results suggest that the patients could discriminate subtle difference in two kinds of tones, although their responses to auditory stimuli were very poor.
Auditory event
Negativity effect
Auditory stimuli
Sensory memory
Auditory perception
Tone (literature)
Cite
Citations (0)
The mismatch negativity (MMN) is an event-related potential component that signifies neurophysiological processing of fine acoustic differences. The MMN indicates attention-independent change detection, reflects auditory sensory memory and provides a physiological measure of difference sensitivity. This paper will provide an overview of current research where results gained by MMN testing in different patient groups were central to the interpretation of an assumed abnormality of processing or storing acoustic features.
Sensory memory
Auditory event
Neurophysiology
Negativity effect
Component (thermodynamics)
Cite
Citations (28)