Effect of Laser Photocoagulation on the Retinal Vessel Diameter inBranch and Macular Vein Occlusion
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To investigate the response of retinal vessel diameters to photocoagulation treatment and their role for the success of laser treatment in patients with retinal vein occlusion.The study included 14 patients with branch vein occlusion or macular vein occlusion. The ophthalmologic examination included best-corrected visual acuity, biomicroscopy, fundus photography, and fluorescein angiography. Retinal vessel diameters were quantified before and after laser photocoagulation using a retinal vessel analyzer.Retinal vessel diameters.In cases manifesting macular vein occlusions, no significant change of the vessel diameter in any vessel was observed during the follow-up period. In the group with branch vein occlusion, all vessels tended to constrict after the laser photocoagulation. The effect of laser treatment on retinal vessel diameters was significant for superotemporal (P =.045, analysis of variance [ANOVA]) and inferotemporal branch veins (P =.03, ANOVA). Vasoconstriction was more pronounced in the occluded branch veins (P =.009, ANOVA) compared with the nonaffected veins (P =.12; ANOVA). The change of visual acuity after 3 months was correlated with the change of vessel diameter 3 months after laser treatment for occluded venular branches (r = 0.78, P =.02, linear regression). There was no correlation between the number of laser burns and the change of vessel diameters in the affected veins in this period (r = 0.12, P =.75, linear regression).Our results show that retinal photocoagulation in patients with branch vein occlusion has a vasoconstrictive effect on occluded veins. The correlation between the change in visual acuity and the change in vessel diameter indicates that branch vein constriction after photocoagulation may be an early indicator of the success of laser treatment.Keywords:
Fundus (uterus)
Retinal Vein
Fundus Photography
Laser coagulation
To investigate the response of retinal vessel diameters to photocoagulation treatment and their role for the success of laser treatment in patients with retinal vein occlusion.The study included 14 patients with branch vein occlusion or macular vein occlusion. The ophthalmologic examination included best-corrected visual acuity, biomicroscopy, fundus photography, and fluorescein angiography. Retinal vessel diameters were quantified before and after laser photocoagulation using a retinal vessel analyzer.Retinal vessel diameters.In cases manifesting macular vein occlusions, no significant change of the vessel diameter in any vessel was observed during the follow-up period. In the group with branch vein occlusion, all vessels tended to constrict after the laser photocoagulation. The effect of laser treatment on retinal vessel diameters was significant for superotemporal (P =.045, analysis of variance [ANOVA]) and inferotemporal branch veins (P =.03, ANOVA). Vasoconstriction was more pronounced in the occluded branch veins (P =.009, ANOVA) compared with the nonaffected veins (P =.12; ANOVA). The change of visual acuity after 3 months was correlated with the change of vessel diameter 3 months after laser treatment for occluded venular branches (r = 0.78, P =.02, linear regression). There was no correlation between the number of laser burns and the change of vessel diameters in the affected veins in this period (r = 0.12, P =.75, linear regression).Our results show that retinal photocoagulation in patients with branch vein occlusion has a vasoconstrictive effect on occluded veins. The correlation between the change in visual acuity and the change in vessel diameter indicates that branch vein constriction after photocoagulation may be an early indicator of the success of laser treatment.
Fundus (uterus)
Retinal Vein
Fundus Photography
Laser coagulation
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Objective:To observe the changes in retinal thickness around the fovea in retinal vein occlusion (RVO). Methods:There were 40 eyes of patients including 30 eyes of central retinal vein occlusion (CRVO) and 10 eyes of branch retinal vein occlusion (BRVO) involved in the study.10 eyes of 10 healthy volunteers served as control group.Optical coherence tomography (OCT) was performed with 2 radial scans centred on the fovea. Results:OCT supplied detailed images of retinal structure in retinal vein occlusion.The nasal rim of fovea (472.30±152.84μm) was thicker than that of temporal rim (390.43±123.96μm) in CRVO.The affectd rim of fovea (513.20±230.32μm) was thicker than that of the opposite rim (335.60±103.41μm) in BRVO. Conclusions:Retinal damage near the occlused site is more severe than that far away in RVO.OCT could reveal minor changes in retinal architecture that can be visualized difficultly following retinal vein occlusion.
Retinal Vein
Fovea centralis
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Objective To observe retinal vein occlusion's(RVO)character in fundus fluorescein angiograohy and discuss the significance in clinic diagnosis.Methods Retrospectively reviewed and analysed the clinical and fundus fluorescein angiography(FFA)data of 298 RVO patients who were confirmed by FFA.Results There are 97 eyes suffering central retinal vein occlusion(CRVO);While,another 201 eyes,suffering branch retinal vein occlusion(BRVO),have 117 occluded retinal veins,most of which(58.21%)are superotemporal veins.There are 12 eyes(5.9%)in hemi-central rentinal vein occlusion.Neovascularization occurs in 32 eyes(10.74% of the total).The prevalence of macular cystoid edema was 104 eyes(35.14% of the total).Retinal capillary nonperfusion is demonstrated in 139 eyes(46.64% of the total),Most cases of RVO occurred 50 years old.Conclusion The morbidity of BRVO is more than CRVO.Most of BRVO are superotemporal veins.Two main complications are neovascularization and macular cystoid edema.FFA contribute to the diagnosis,types,therapy and prognosis of RVO.
Retinal Vein
Fundus (uterus)
Fundus fluorescein angiography
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Aim to analyze and compare the effectiveness of conservative treatment and complex methods (intravitreal injections of angiogenesis inhibitors and retinal laser coagulation) of the central retinal vein occlusion treatment.
Material and methods. Based on the case histories, there were analyzed the results of central retinal vein occlusion treatment in 40 patients (the average age is 63) who were treated at the Republican Ophthalmological Hospital.
Results. The course of combined therapy including the anti-VEGF injections and retinal laser coagulation showed the best results: a more significant and persistent decrease of retinal edema and a more marked increase of visual acuity, if compared to conservative therapy of the central retinal vein occlusion.
Conclusion. The results obtained allow us to recommend the complex treatment of the central retinal vein occlusion as the best method for fast and persistent elimination of retinal edema, increased visual acuity and prevention of complications.
Retinal Vein
Laser coagulation
Central retinal vein
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Objective To assess the effect of vitrectomy for vitreous hemorrhage secondary to retinal vein occlusion.Methods Retrospectively analyzed 241 patients with vitrectomy for vitreous hemorrhage which were 28 retinal vein occlusion patients(11.6 %).Evaluated the sites,visual prognosis,retinal vein occlusion-related complications and surgery-related complications,following-up of 6 months to 2 years.Results 26 patients visual acuity increased(92.9%),2 cases remained(7.1%).11 cases of central retinal vein occlusion,17 cases of branch vein occlusion in the 28 patients.Postoperative visual acuity of branch retinal vein occlusion was better than the central retinal vein occlusion(Z = 1.1342,P = 0.0235).Patients'course less than 2 months(10 cases),got better visual prognosis than more than 2 months(18 cases)(P 0.05).Improved visual acuity in combined surgery with statistically significant difference than vitrectomy(P 0.05).Conclusion Vitrectomy is an effective treatment for vitreous hemorrhage secondary to retinal vein occlusion.Surgery opportunity after 2 ～ 3 months when clots not absorbed.Cataract extraction combined with vitrectomy is safe and feasible for cataract combined with vitreous hemorrhage secondary retinal vein occlusion.
Vitreous hemorrhage
Retinal Vein
Central retinal vein
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The purpose of this study was to evaluate the effects of intravitreal bevacizumab injection in the treatment of macular thickness and reduced visual acuity in patients with branch retinal vein occlusion.In this retrospective study, we evaluated 15 eyes of 15 consecutive patients diagnosed with branch retinal vein occlusion between May 2008 and June 2011 at our institution. Detailed ophthalmologic examination, optical coherence tomography, and/or fundus fluorescein angiography was performed at diagnosis and during follow-up. A 1.25 mg intravitreal bevacizumab injection was administered to all patients on average 2.73 (1-7) times. Visual acuity and macular thickness were evaluated before and after treatment.Eleven patients were female (73.3%) and four were male (26.6%). The mean patient age was 62.6 years. The patients were followed for a mean of 11.4 (range 4-24) months. Mean best-corrected visual acuity was 0.92 ± 0.52 logMAR (logarithm of the minimum angle of resolution) before treatment and 0.66 ± 0.42 logMAR at the last examination. The increase in visual acuity was found to be statistically significant (P = 0.031). Mean macular thickness was 395.46 ± 106.55 μm before treatment and 302.26 ± 84.6 μm after the final treatment. The decrease in macular thickness was statistically significant (P < 0.001).Intravitreal bevacizumab injection was effective for treatment of retinal vein branch occlusion.
Fundus (uterus)
Retinal Vein
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To evaluate quantitatively the effect of grid laser photocoagulation in macular edema due to central and branch retinal vein occlusion, using the retinal thickness analyzer.Five patients with cystoid and non-cystoid macular edema were studied before and after argon grid laser treatment. All were examined clinically, with fluorescein angiography, and measurement of retinal thickness. Macular thickness was correlated to visual acuity measured on the ETDRS chart.Laser-slit images obtained with the retinal thickness analyzer in patients with macular edema disclosed discrete intraretinal changes after photocoagulation. Biomicroscopy and fluorescein angiography were insensitive to these small changes in the retinal thickness. No patient had any change in visual acuity after three months, but the retinal thickness was greater at this interval. The retinal thickening may be explained by a postoperative inflammatory response or by altered retinal blood flow or, in two of the eyes, by the effect of combined peripheral photocoagulation.The retinal thickness analyzer offers a refined tool for the diagnosis of subclinical changes of macular edema in retinal vein occlusion and is therefore also useful for assessing the effects of treatment.
Retinal Vein
Central retinal vein
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OBJECTIVE To study Characteristic of optic disk vein branch in the patients with hemi retinal vein occlusion (HRVO) and normal retinal vessels METHODS Retinal vein branch of optic disc, fundus condition and prognosis of the visual acuity were observed and with color photograph, fundus fluorescein angiography, and 90D Hruby and slit lamp in forty seven patients (48 eyes) The data of the patients were compared with normal retinal vessels of 26 cases (30 eyes) RESULTS (1)The percentage of one branch was 7 1% in the patients with HRVO and 33 3% in the normal retinal vessels ( P 0 05 ); there were 67 9% and 50 0%( P 0 05),25 0% and 16 7%( P 0 05) respectively in two branches and three branches (2) Position of occlusion: there were 21 eyes (43 8%) in the superior branch occlusion of retinal vein; 26 eyes (54 1%) in the inferior branch; and 1 eye (2 1%) was diagonal position The were 21 eyes (43 8%) were ischemic and 19 eyes (39 6%) were nonischemic in those eyes, and the recorded of 8 eyes (16 6%) were not detailed (3) The prognosis of visual acuity: The follow up time was average of 7 months in 40 patients with HRVO The initial visual acuity 0 2 or more were 26 eyes (65 0%),and 34 eyes ( 85 0%) last number of for the visual acuity 0 5 or more eyes was increased from 11 eyes (2 7 5%) to 17 eyes (42 5%) among them in the follow up period (4)Complications: The macular cystoid edema were 19 eyes (39 6%), and retinal neovascularization 7 eyes (14 6%) including optic disk neovascularization 2 eyes (4 2%) among 48 eyes One eye (2 1%)was only optic disk neovascularization CONCLUSION When the retinal vein branches in optic disc vein were two the ratio of HRVO was higher The prognosis of visual acuity and complications is milder than central retinal vein occlusion, and more serious than branch retinal vein occlusion
Fundus (uterus)
Retinal Vein
Optic disc
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Objective To investigate the relative factor, danger factor, and complications which affected visual acuity in patients with retinal vein occlusion. Methods One hundred and forty-one patients with retinal vein occlusion were studied retrospectively after treatment for three months. Results 76. 60% of the total patients were aged 55 years. 93. 93% of the lesions occurred in the temporal branch of the retinal vein. If original visual acuity was good, the extent of occlusion was small, and the prognosis of visual acuity would be better. Arteriosclerosis was the most dangerous factor leading to retinal vein occlusion and hypertension. Cystoid macular edema (CME) occupied the highest rate of the complications of retinal vein occlusion. Photocoagulation had significant effect on improving visual acuity of the patient with branch retinal vein occlusion, but no obvious effect on the patient with complete retinal vein occlusion. Conclusion There is close relationship between retinal vein occlusion and body status. CME is the main factor leading to reduce visual acuity. In concern to the prognosis of visual acuity, original visual acuity and extent of occlusion were closely related. Photocoagulation has significant effect on preventing complications of retinal vein occlusion, protecting and improving visual acuity in early stage.
Retinal Vein
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