Role of Airway Eosinophilia and Eosinophil Activation in Sephadex-induced Inflammation
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We report the histological, histochemical, immunohistochemical, and ultrastructural features in a case of gastric carcinoma with squamous differentiation and massive eosinophil infiltration, with peripheral blood eosinophilia, without evidence of allergic or parasitic disease. The unfavourable prognostic significance of squamous differentiation and eosinophilia is pointed out. The hypothesis of more aggressive cellular clones, within the neoplasia, capable of expressing morphological changes and/or different functional activities is considered.
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Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by central eosinophilic degeneration or necrosis, prominent eosinophils, many multi-nucleated giant cells and abundant fibroblasts. They were restricted to the cecal submucosa. The mesenteric arteritis consisted of fibrinoid necrosis of the intima and media, intense inflammatory cell infiltration and fibrosis in the arterial wall. An affected artery in the cecum was continuous with the mesenteric artery. The foregoing tissue changes in this rat correlate with the high absolute blood eosinophil count found in this animal.
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We report a case of esophageal squamous cell carcinoma (SCC) with marked eosinophil infiltration which was identified postoperatively in the esophageal wall in areas not surrounding the SCC. The eosinophil infiltration was seen in the submucosa, muscle and adventitia, but not in the mucosa. Eosinophilic esophagitis (EoE) is a pathological condition defined as eosinophil infiltration within the esophageal mucosa. Eosinophil infiltration at the invasion front of esophageal SCC is termed tumor-associated tissue eosinophilia (TATE). However, the eosinophil infiltration in this case may be pathologically different from both EoE and TATE. To our knowledge, this is the first report of esophageal SCC with eosinophil infiltration.
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List of contributors Preface Structural analysis of amino acid and cDNA nucleotide sequence of eosinophil major based protein Immunoglobulin receptors on eosinophil leucocytes Interleukin-5 Eosinophil chemotactic factors in asthma and allergy Interactions between monocytes, macrophages and eosinophils Interactions between PAF, cytokines, the CD 11/18 complex and eosinophil adherence reactions in vitro IgE-dependent eosinophil effector mechanisms Eosinophils and pulmonary hyperresponsiveness in the rat Potential involvement of interleukin-5 and platelet-activating factor in eosinophil recruitment in the rat The role of neutophils and eosinophils in a model of asthma in the guinea pig Eosinophil granule proteins in bronchial asthma Mononuclear cell-derived eosinophil-activating factors Inhibition of allergen-induced cutaneous eosinophilia Eosinophils, T-lymphoeytes and late-phase skin reactions Inhibition of PAF-induced eosinophilia by AH 21-132 Eosinophils and bronchial hyperresponsiveness in bronchial astma Pharmacology of eosinophils Index
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We evaluated the bronchial hyperresponsiveness to methacholine in the two cases of eosinophilic pneumonia with infiltration of eosinophils into bronchial mucosa. Bronchial responsiveness was not increased in either case in spite of marked infiltration of eosinophils into the bronchial mucosa and submucosa. Hypodense eosinophils are reported in the sputum of patients with bronchial asthma. This suggests that infiltration of activated eosinophils into the bronchial mucosa is an essential factor in bronchial hyperresponsiveness.
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The authors examined 25 minute early gastric cancers (EGC) and 13 small EGC in order to investigate the incidence and possible causes for the infiltration of eosinophils. The degree of eosinophil infiltration was higher in tumour stroma than in adjacent normal-appearing mucosa; this correlation was statistically significant (P < 0.001). Tumour-associated tissue eosinophilia (TATE) was not correlated with size, histological type, necrosis of the tumour nor gastritis activity in adjacent non-tumoral mucosa. Electron microscopy, performed in 4 cases of small EGC, showed tumour stromal eosinophils with morphological evidence of activation similar to those described for tissue eosinophils in various disorders. Some tumour cells in intimate contact with activated eosinophils exhibited focal cytopathic changes. TATE represents local inflammation probably leading to tumour cell damage. The immunological role of the eosinophils against tumour cells in vivo deserves further investigation.
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Submucosa
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