Obestatin, Acyl Ghrelin, and Des-acyl Ghrelin Responses to an Oral Glucose Tolerance Test in the Restricting Type of Anorexia Nervosa
Toshiro HaradaToshihiro NakaharaDaisuke YasuharaShinya KojimaKen‐ichiro SagiyamaHaruka AmitaniAlessandro LavianoTetsuro NaruoAkio Inui
93
Citation
21
Reference
10
Related Paper
Citation Trend
Keywords:
Obestatin
Anorexia nervosa
Ghrelin, a circulating peptide hormone produced in the stomach, has attracted much attention because of its stimulatory effect on food intake, but the effect of ghrelin may represent only half the story. Using a bioinformatics approach, Zhang et al. (see the Perspective by Nogueiras and Tschöp) show that ghrelin encodes a second peptide hormone that is processed from the same protein precursor as ghrelin. In rodents, a synthetic version of this hormone, obestatin, has the opposite physiological effect as ghrelin--it suppresses food intake. Obestatin mediates its actions through an orphan G protein-coupled receptor, GPR39, which shares sequences with, but is distinct from, the receptor targeted by ghrelin. J. V. Zhang, P.-G. Ren, O. Avsian-Kretchmer, C.-W. Luo, R. Rauch, C. Klein, A. J. W. Hsueh, Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 , 996-999 (2005). [Abstract] [Full Text] R. Nogueiras and M. Tschöp, Separation of conjoined hormones yields appetite rivals. Science 310 , 985-986 (2005). [Summary] [Full Text]
Obestatin
Cite
Citations (0)
To investigate the role of ghrelin and obestatin in obesity mechanisms.A total of 88 obese children and 25 normal children were enrolled. Moreover, 46 obese children took part in a summer camp for weight reduction. Fasting ghrelin, obestatin and other biochemical parameters were measured in all subjects and re-measured in 45 obese children finishing the camp.The ghrelin levels in the control and obese groups were 67.26 +/- 23.41 pmol/L and 56.53 +/- 15.97 pmol/L with a significant difference (p = 0.039), while the obestatin levels (89.41 +/- 23.63 vs. 83.13 +/- 17.21 pmol/L) were not significantly different (p = 0.083). The ghrelin/obestatin ratio in the controls was significantly higher than that in the obese group (p = 0.014). In the latter, fasting insulin and alanine aminotransferase were independent factors for ghrelin; fasting insulin, weight and gender were independent factors for obestatin and alanine aminotransferase was an independent factor for ghrelin/obestatin. Moreover, ghrelin, obestatin and ghrelin/obestatin increased after weight reduction (p < 0.05, respectively), and the increment in ghrelin and obestatin was associated with a decrement in insulin resistance.These data suggest that ghrelin, obestatin and/or the ghrelin/obestatin ratio are associated with obesity in childhood.
Obestatin
Cite
Citations (61)
Ghrelin gene can generate various bioactive molecules besides Ghrelin.In this review,not only the Ghrelin derived peptide were introduced,but the physiological functions,distributions and the factors which affect secretion of Des-acyl ghrelin and Obestatin were reviewed.This paper aimed to provide theoretical basis for future researches on Des-acyl ghrelin and Obestatin in the field of animal production.
Obestatin
Cite
Citations (0)
Background Ghrelin and obestatin are two gastric hormones encoded by the same preproghrelin gene that convey information concerning nutritional status to the central nervous system. Ghrelin has been considered as an appetite stimulating peptide that has a role in the regulation of energy homeostasis. Obestatin has been described for its appetite suppressing effects opposing ghrelin's effect on food intake. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese children compared to non-obese and correlate them to food macronutrients intake. Methods This study is a cross-sectional case control study comprising 60 obese children, in addition to 31 age- and sex-matched controls. All children were subjected to clinical examination, anthropometric assessment, and a 3-day 24-h dietary recall. Fasting serum ghrelin and obestatin levels were evaluated, the ghrelin/obestatin ratio was calculated and they were correlated to macronutrients intake. Results Obese children had significantly lower serum fasting levels of ghrelin, obestatin and the ghrelin/obestatin ratio than the control group. The mean intake of total energy and macronutrients was significantly higher in obese children. Ghrelin showed positive correlation with total energy and fat intake in the obese group. Obestatin had positive correlations with total energy and fat intake while the ghrelin/obestatin ratio had a negative correlation with the total energy intake in the control group. Conclusions Ghrelin, obestatin and the ghrelin/obestatin ratio were significantly lower in obese children and significantly associated with their total energy intake. Disturbed ghrelin to obestatin balance may have a role in the etiology and pathophysiology of obesity.
Obestatin
Energy homeostasis
Cite
Citations (14)
Obestatin
Gastroparesis
Cite
Citations (19)
Background: Obestatin and ghrelin are two gastric hormones that have a potential role in dietary intake regulation. Obestatin/ghrelin ratio has been proposed as activity markers in obesity. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese compared to control subjects and to determine their relationship with anthropometric and metabolic parameters. Methods: Fasting obestatin and ghrelin levels were measured using enzyme-linked immunosorbent assay ELISA in 28 obese and 24 healthy subjects. The fasting ghrelin/obestatin ratio was calculated. Anthropometric and metabolic parameters were also assessed. Results: Obese patients had significantly lower obestatin and ghrelin blood levels compared with controls. The Ghrelin/Obestatin ratio was significantly lower in obese group 0.813±0.0417 ng/ml than in the control group 0.896±0.049 ng/ml, (p<0.001). In obese patients, obestatin and ghrelin were significantly and negatively correlated with BMI and positively correlated with HDL-C. Conclusion: Circulating preprandial ghrelin to obestatin ratio is decreased obese subjects. We suggest that low preprandial ghrelin to obestatin ratio may be involved in the etiology and pathophysiology of obesity.
Obestatin
Cite
Citations (1)
三肽， ghrelin， des 酰 ghrelin 和 obestatin 从普通专业版荷尔蒙被导出， preproghrelin 由张贴翻译处理，在胃从内分泌的房间发源。检验这些肽的效果，我们在自由地感动有意识的老鼠模特儿使用了胃肠的活动性的压力计的测量。Ghrelin 在美联储和动物的 fasted 状态在窦和十二指肠的活动性上施加 stimulatory 效果。Des 酰 ghrelin 处于动物的 fasted 状态在窦的活动性上，然而并非在十二指肠的活动性上施加禁止的效果。Obestatin 处于喂的状态，然而并非处于动物的 fasted 状态在窦和十二指肠的活动性上施加禁止的效果。在大脑的 NPY Y2 或 Y4 受体可以调停 ghrelin 的行动，在大脑的 CRF 类型 2 受体调停 des 酰 ghrelin 的行动，而 CRF 录入 1 和类型 2 受体，大脑调停 obestatin 的行动。迷走神经传入路径可能涉及 ghrelin 的行动，然而并非在 des 酰 ghrelin 的行动包含了，而迷走神经传入路径力量部分涉及 obestatin 的行动。
Obestatin
Cite
Citations (0)
Obestatin
Anorexia nervosa
Cite
Citations (93)
Circulating Ghrelin Levels and Obestatin/Ghrelin Ratio as a Marker of Activity in Ulcerative Colitis
Background/Aims Ghrelin levels are known to increase in patients with ulcerative colitis (UC), but serum obestatin levels in UC patients are not well elucidated. The aim of this study was to examine the relationship between serum ghrelin and obestatin levels and disease activity in UC patients. Methods The serum ghrelin and obestatin levels were measured in 21 UC patients (12 with active disease and 9 in remission) using enzyme-linked immunosorbent assay. The relationship between the circulating levels of these 2 hormones and disease activity was analyzed. The colonic mucosal mRNA expression of ghrelin and obestatin was measured by quantitative reverse transcription polymerase chain reaction. Results The mean serum ghrelin values were significantly higher in patients with active disease than in patients with remission (1370.6±404.3 vs. 783.5±235.3 pg/mL, P=0.001). Colonic mucosal mRNA expression of ghrelin was also significantly higher in patients with active disease than in patients in remission (0.805±0.214 vs. 0.481±0.356, P=0.018). However, the mean serum obestatin levels and colonic mucosal mRNA expression of obestatin were not significantly different between both groups. The circulating obestatin/ghrelin ratio was significantly lower in patients with active UC than in patients in remission (0.32±0.08 vs. 0.58±0.20, P=0.001). Conclusions The serum ghrelin levels and the obestatin/ghrelin ratio were related to the activity of UC, but serum obestatin was not related to activity of UC. The ghrelin levels and the obestatin/ghrelin ratio could serve as activity markers in patients with UC. Keywords: Colitis, ulcerative; Disease activity; Ghrelin; Obestatin; Ratio
Obestatin
Cite
Citations (22)