Piperazine (Antepar) Neurotoxicity
21
Citation
6
Reference
10
Related Paper
Citation Trend
Abstract:
PIPERAZINE, available for oral use as the citrate,¶ has been found effective against pinworm and ascaris infections.1 2 3 Its structural formula is as follows: Widespread experience with this compound has disclosed virtually no significant toxic manifestations at recommended doses of 50 to 75 mg. of the hexahydrate per kilogram of body weight per day, and only mild diarrhea and occasional urticaria are listed in a standard textbook of pharmacology.4 Neurologic findings have been reported in England by White and Standen5 and by Sims,6 and in this country by Howie,7 in patients taking up to three times the recommended dosage. An unusual . . .Keywords:
Piperazine
Neurotoxicity
Piperazine
Cite
Citations (27)
Piperazine is taken as parent compound,bromacetophenone and its derivatives are made to have substitution reaction with 1-ethoxycarbonyl piperazine,and then some prochirality compounds are received by hydrolyzing.13 compounds(3 of which are novel) are synthesized together,4 of which are desired.As this method is simple and easy,the yield is relatively high,and it could be used in the commercial process.
Piperazine
Cite
Citations (0)
A series of monosubstituted piperazine derivatives were obtained by the reaction of piperazine with trimethylacetic arylcarboxylic anhydrides in good yields, which were prepared in situ from arylcarboxylic acid with trimethylacetyl chloride in the presence of triethylamine.
Piperazine
Triethylamine
Reaction conditions
Cite
Citations (8)
The densities and viscosities of aqueous solutions of piperazine (PZ) and aqueous blends of 2-amino-2-methyl-1-propanol (AMP) and piperazine have been measured at (298, 303, 308, 313, 318, 323, 328, and 333) K. The experiments covered the concentration range of (0.2 to 0.8) mol·L-1 piperazine (mass fraction piperazine (1.74 to 6.88) %) for the (PZ + water) system and mass fraction of (2 to 8) % for piperazine-activated blended AMP solutions. The results are compared with the available data in the literature. The experimental density and viscosity data were correlated as a function of temperature and concentration of amine.
Piperazine
Mass fraction
Propanol
1-Propanol
Cite
Citations (87)
Piperazine-containing compounds serve as one of the most important classes of compounds throughout all fields of chemistry. Alas, current synthetic methods have fallen short of providing a general method for the synthesis of highly decorated piperazine fragments. Herein, we present a site-selective approach to the C–H functionalization of existing piperazine compounds using photoredox catalysis. This manifold relies on the predictable differentiation of electronically distinct nitrogen centers within the piperazine framework, granting access to novel C-alkylated variants of the starting piperazines.
Piperazine
Photoredox catalysis
Surface Modification
Cite
Citations (60)
Abstract Piperazine based compounds are gaining more attention in today’s research as the piperazine nucleus is found in many biologically active compounds. Substitution in nitrogen atom of piperazine with a suitable fragment containing donor atoms, make it unique for versatile binding possibilities with metal ion. Piperazine derived ligands and their metal complexes have shown applications in different fields like antimicrobial, antioxidant, antihistaminic, anticancer, DNA binding and protein binding, catalyst in ring opening polymerization (ROP), etc. Metal-organic framework derived from piperazine based ligands has also been reported in the literature. This paper presents the synthesis, and characterization of a series of piperazine based ligands. The asymmetrical ligands have been synthesized by cyclization of bis-chloroethyl amine with suitable amine. Some of the representative metal complexes are also synthesized and characterized.
Piperazine
Cite
Citations (5)
The treatment of 2-fluorobenzylchloride (1), 3-fluorobenzylchloride (2), 4-fluorobenzylchloride (3), 3-trifluoromethylbenzylchloride (4) and 4-trifluoromethylbenzylchloride (5), 2-fluorobenzylbromide (6), 3fluorobenzylbromide (7), 4-fluorobenzylbromide (8), 3trifluoromethylbenzylbromide (9) and 4-trifluoromethylbenzylbromide (10) with piperazine (A) in the presence of triethylamine gave the corresponding 1,4-Di-(2-fluorobenzyl)-piperazine (11), 1,4-Di-(3fluorobenzyl)-piperazine (12), 1,4-Di-(4-fluorobenzyl)-piperazine (13), 1,4-Di-(3-trifluoromethylbenzyl)-piperazine (14) and 1,4-Di-(4trifluoromethylbenzyl)-piperazine (15) in reasonably good yields. In analogous reactions, morpholine (B) reacted smoothly with 1-10 to form the respective fluorine containing monosubstituted derivatives (16-20) in moderate yields. The compounds were characterized by using IR, and 1 H and 19 F NMR spectroscopy, MS and elemental analysis. The piperazine derivatives (11-15) and morpholine derivatives (16-20) have been subjected to antibacterial screening.
Piperazine
Morpholine
Triethylamine
Cite
Citations (0)
Abstract A solution of piperazine or its salts is heated with 2,6-dichloroquinonechlorimide, and the color produced is measured at 525 nm to obtain the concentration of piperazine. The color developed obeys Beer’s law in the concentration range of 6.4–51.2 μg piperazine/ml. The results of the proposed method agree with those of the official methods within ± 1.0% for piperazine and its salts and ± 2.0% for formulations. The method is rapid and precise and gives reproducible results. It is suitable for the analytical control of piperazine or its salts and their formulations.
Piperazine
Cite
Citations (2)
Abstract 1,4-Diamino-2,3,5,6-tetra(hydroxyimino)piperazine (DAPH4), 1-amino-4-(phenyl)-2,3,5,6-tetra(hydroxyimino)piperazine (PAPH4), 1-amino-4-(1-naphthyl)-2,3,5,6-tetra(hydroxyimino)piperazine (NAPH4) and 1-amino-4-(benzyl)-2,3,5,6-tetra(hydroxyimino)piperazine (BAPH4) were synthesized by the reaction of cyanogen di-N-oxide with substituted aminoglyoximes at −10°C. Their polymeric complexes with Ni(II), Cu(II) and Co(II) were prepared and characterized by 1H NMR, UV.-visible, IR and elemental analyses.
Piperazine
Tetra
Cite
Citations (0)
Crystalline products of the reactions of piperazine (PZ) solutions with CO2 sourced from the air and dry ice represent three carboxamides of piperazine, piperazinium carboxamide trihydrate (PZH+CO2−)·3H2O, piperazinium piperazine-4-carboxamide (PZH+)(PZCO2−), and bis-(piperazinium) piperazine-1,4-bis(carboxamide) trihydrate (PZH+)2(PZ(CO2−)2)·3H2O, whose crystal structures were revealed by single crystal X-ray diffraction studies. The interplay of hydrogen bonding affords the crystal stability of these hydrolytically labile piperazine carbamate derivatives which have not been observed in the solid state before. The crystal structure of piperazine monohydrate PZ·H2O is reported as well.
Piperazine
Carboxamide
Crystal (programming language)
Cite
Citations (10)