Synthesis and characterization of a series of phenyl piperazine based ligands
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Abstract Piperazine based compounds are gaining more attention in today’s research as the piperazine nucleus is found in many biologically active compounds. Substitution in nitrogen atom of piperazine with a suitable fragment containing donor atoms, make it unique for versatile binding possibilities with metal ion. Piperazine derived ligands and their metal complexes have shown applications in different fields like antimicrobial, antioxidant, antihistaminic, anticancer, DNA binding and protein binding, catalyst in ring opening polymerization (ROP), etc. Metal-organic framework derived from piperazine based ligands has also been reported in the literature. This paper presents the synthesis, and characterization of a series of piperazine based ligands. The asymmetrical ligands have been synthesized by cyclization of bis-chloroethyl amine with suitable amine. Some of the representative metal complexes are also synthesized and characterized.Keywords:
Piperazine
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In the title compound, C15H17N3O, the aldehyde group is twisted relative to the quinoline group by17.6 (2)° due to the presence of a bulky piperazinyl group in the ortho position. The piperazine N atom attached to the aromatic ring is sp (3)-hybridized and the dihedral angle between the mean planes through the the six piperazine ring atoms and through the quinoline ring system is 40.59 (7)°. Both piperazine substituents are in equatorial positions.
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The combination of a piperazine and boronic groups within one molecule can result in a totally novel biological activity.
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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bis-(2-chloroethy1)amine was synthesized from raul material diethanolamine with SOCl2 in this study.1-(3-chloropheny1)piperazine was obtained in the substituted reaction of bis-(2-chloroethy1)amine with 3-chloroaniline,and reacted with 1-bromo-3-chloropropane to give 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine.The 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine is important medicinal intermediates to preparation of 1,4-N,N-substituted piperazines.
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The triphenylbismuth diacetate reacted selectively with different aminoindazole derivatives in presence of copper diacetate to engender a new series of mono phenyl aminoindazole compounds in good to high yields. Moreover, the same reagent with 4-chloro-2-methyl-2H-indazol-7-amine led to a mixture of mono- and N,N-diphenylaminoindazoles. However, its combination with 2H-indazol-4-amine provided only one N,1-diphenylaminoindazole compound.
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Abstract The "racemic" diketopiperazines (III), which are obtained from the self‐condensation of DL‐amino acid esters such as (I) are shown to consist of mixtures of the cis‐ and trans‐isomer.
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