Split-course Chemoradiotherapy: An Effective Treatment of Anal Cancer in the Frail or Elderly
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The treatment of choice for anal cancer is chemoradiotherapy.Skin reaction and bowel symptoms such as tenesmus, diarrhoea and bleeding are common side effects.We report a patient who developed stridor as a result of chemoradiotherapy for anal cancer and discuss the pathogenesis and potential consequences.
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It is well established that persons living with HIV (PLWH) have highly elevated rates of anal HSIL and anal cancer compared with those who are not living with HIV. The 5-year risk of anal cancer following anal HSIL has been reported to be as high as 14.1% among PLWH compared with 3.2% among those who are not living with HIV. To address these concerns, the AIDS Malignancy Consortium completed a large-scale, randomized trial to compare strategies for the prevention of anal cancer among PLWH with anal HSIL. The objective of the study was to determine whether treating anal HSIL was effective in reducing the incidence of anal cancer in PLWH compared with active monitoring. This paper describes the design of the ANal Cancer/HSIL Outcomes Research Study (ANCHOR) with respect to estimating the anal cancer event rate in this high risk population.
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Immunosuppression
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Chemoradiotherapy
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Chemoradiotherapy
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This editorial describes the contents of this special issue of Sexual Health devoted to anal cancer. The aim of the issue is to provide readers with information to assist them in making decisions about what to do about detecting anal cancer early in men who have sex with men with HIV. Should they be advocating screening? It discusses the epidemiology of HPV infection, anal intraepithelial neoplasia, and anal cancer in MSM, heterosexual men and women; anal cancer screening and treatment of anal cancer. And most importantly, what should be done about vaccinating boys with the HPV vaccine.
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Anal Carcinoma
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Anal cancer accounts for only 1.5% of  gastrointestinal malignancies but this disease has shown a steady increase in incidence particularly in HIV positive males. The understanding of pathophysiology and treatment of anal cancer has changed radically over last thirty years . Risk factors have been identified and organ preservation by chemoradiotherapy has become a standard. This article aims to review  the clinical presentation, diagnostic evaluation, and treatment options for anal cancer in the light of current literature . Key words : anal cancer, anal canal, anal margin, chemoradiotherapy, HIV, HPV, salvage, recurrence, imaging.
Chemoradiotherapy
Anal Carcinoma
Presentation (obstetrics)
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Anal cancer incidence is elevated among HIV-infected individuals, especially men who have sex with men (MSM). However, no national guidelines exist for anal cancer screening or treatment of precancerous anal lesions, in part because data are lacking on progression of anal intraepithelial neoplasia (AIN) to anal cancer. To explore this issue, researchers in Australia reviewed the records of 574 patients (95% MSM, 73% …
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Заболеваемость раком анального канала настолько стабильно растет, что, как отмечается в специальной литературе, за последние 20 лет практически удвоилась. Почти все случаи заболевания сочетаются с персистирующей инфекцией – вирусом папилломы человека и вирусом иммунодефицита. Раку анального канала часто сопутствуют аногенитальный рак, остроконечные кондиломы, интраэпителиальная гиперплазия шейки матки и рак шейки матки. До сих пор лечение пациентов с диагнозом рака анального канала носит разнородный характер и отличается ограниченным клиническим опытом. The number of anal cancer diagnoses has been rising steadily, so that the incidence has doubled in the past 20 years. Almost all anal cancer are induced by persistent infection with human papillomaviruses and/or immunodeficiency. Anal cancer is associated with a history of HPV-related anogenital disease, including anogenital warts, as well as gynecological intraepithelial neoplasias and cancer. Hitherto the care of patients with anal cancer has been heterogeneous and little experience exists with the primary management of anal cancer.
Anus neoplasms
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