Normative Distribution of Complete Blood Count from Early Childhood through Adolescence: The Bogalusa Heart Study
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Mean corpuscular hemoglobin
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Complete blood count
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Background: Febrile seizures (FS) are the most common type of convulsion in young children. The predisposing factors are still under investigation; however, iron insufficiency might play a role in this regard. Objectives: Our objective was to determine the association between iron status and febrile seizure. Patients and Methods: This prospective case-control study was conducted among 109 children aged 6 months to 6 years and hospitalized for the first episode of FS. The case group was compared to a group of 70 age- and sex-matched controls admitted to the same ward with the same diagnosis of infection. The control and case groups were matched based on family history of FS, age, sex, temperature, cause of illness, erythrocyte sedimentation rate (ESR), white blood cells (WBC), and platelets. Venous blood samples were examined for complete blood count (CBC), serum iron, serum ferritin, and total iron-binding capacity. The CBC included measurements of red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), WBC, and platelets. Results: There were no significant differences between the study groups in terms of temperature, ESR, WBC, and platelets. The mean Hb, HCT, ferritin, iron, and MCH were significantly lower in the case group than in the control group. The mean level of MCV in the FS group was lower than the mean level of MCV in the control group, but the difference was not significant. Conclusions: Low levels of serum ferritin and iron might play a role in the pathogenesis of simple febrile seizure. Further longitudinal studies are clearly needed to confirm our findings.
Mean corpuscular hemoglobin
Complete blood count
White blood cell
Venous blood
Erythrocyte sedimentation rate
Mean platelet volume
Febrile seizure
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Objective To investigate the changes of red blood cell volume distribution width (RDW) and its clinical significance in children with malnutritional and anemia.Methods The RDW was detected and analysed in 63 children who were suffered from moderate or severe malnutrition complicated with anemia.The control group included 30 children who were out-patient health examination.The hemoglobin(Hb),red blood count(RBC),mean corpuscular volume (MCV),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC) and RDW were detected in both groups.Results According to the MCV、MCHC,the children of malnutritional anemia were devided into three types of anemia including macrocytic anemia,normocytic anemia and microcytic anemia.There was no significant difference in RDW among three types of anemia.The RDW in malnutrition group was more significantly elevated than that in control group(P0.01).Conclusion RDW is of great importance in diagnosing malnutritional anemia.
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Asparaginase, an effective drug in the treatment of childhood acute lymphoblastic leukemia (ALL), has become an important component of most childhood ALL regimens during the remission induction or intensification phases of treatment. The incidence range of asparaginase-associated lipid abnormalities that are seen in children is 67–72%. Lipemia causes erroneous results, which uses photometric methods to analyze blood samples. We describe a case of l-asparaginase-associated severe hyperlipidemia with complete blood count abnormalities. Complete blood count analysis was performed with Beckman COULTER® GEN·S™ system, which uses the Coulter Volume, Conductivity, Scatter technology to probe hydrodynamically focused cells. Although an expected significant inaccuracy in hemoglobin determination occurred starting from a lipid value of 3450 mg/dl, we observed that triglyceride level was 1466 mg/dl. Complete blood count analysis revealed that exceptionally high hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration levels vs. discordant with red blood cell count, mean corpuscular volume, and hematocrit levels. Total leukocyte count altered spontaneously in a wide range, and was checked with blood smear. Platelet count was in expected range (Table 1). Thus, we thought it was a laboratory error, and the patient’s follow-up especially for red cell parameters was made by red blood cell and hematocrit values. Table 1. Patient’s complete blood count analysis according to the days of induction Day of induction Hb (g/dl) Hct (%) MCV (fl) MCH (pg) MCHC (g/dl) RDW (%) RBC (× 106/μl) WBC (× 10³/μl) Plt (× 10³/μl) 26 11.2 30.8 92 34 36.5 18 3.3 1.2 124 30 14.1 31 93 42 45 17.6 3.4 10.1 156 33 16.8 27 92 57 62 17 2.9 2.3 113 36 18.9 29 97 63 65 18.9 3.01 13.5 182 37 13.6 28.5 98 47 47 20 2.8 6.7 151 38 8.9 26.3 98 33 33 22 2.6 2.7 117 Hb, hemoglobin; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin; Hct, hematocrit; RBC, red blood cell count; RDW, red cell distribution width; WBC, white blood cell count; Plt, platelet count.
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Objectives: Hemoglobin & red blood cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width) among adolescent. Study Design: Cross-Sectional study (Descriptive). Setting: Department of Physiology, Baqai Medical University (BMU) Karachi. Period: 6 months from February to August 2017. Material & Methods: A total of 500 students of MBBS, BDS, DPT with having age ranges from 18-25 years were enrolled in this study. The anthropometric measurement [height (m2) and weight (kg)] was recorded for calculation of the Body Mass Index and Complete blood count i-e Hemoglobin (Hb%), Mean Corpuscular Volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW) was done and calculated. Data analysis was done on Microsoft excel & SPSS version 22.0 was used. Results: It was seen that the comparison of Hb%, MCV & RDW had no significant (p>0.001) association of study participants to different categories of Body Mass Index. Mean corpuscular hemoglobin (MCH) (X²=28.278, p<0.001) and Mean corpuscular hemoglobin concentration (MCHC) (X²=15.659, p=0.016) were statistically significantly association with different categories of Body Mass Index. Conclusion: Mean corpuscular hemoglobin and Mean corpuscular hemoglobin concentration had statistically significant (p<0.001) association with body mass index (BMI).
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A complete blood cell count (CBC) is one of most common test requested by a doctor that gives information about the cells in a patient`s blood. These days, counting the cells in a patient`s blood is generally automated by use of an automated analyzer. Because an automated cell counter samples and counts so many cells, the results are very precise. In addition to counting, automated analyzers also measure the amount of hemoglobin in the blood and red blood cell indices including mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red blood cell distribution width (RDW). These informations are very helpful to a physician who is trying to identify the cause of a patient`s disease. If the red cells are smaller or larger than normal, or if there`s a lot of variation in the size of the red cells, these data can help guide the direction of further testing and expedite the diagnostic process so patients can get the treatment they need quickly. Therefore, we need to pay more attention to the interpretation of CBC results. (Korean J Med 78:531-539, 2010)
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In this study, hematology was evaluated in jundiá fish males and females fed with three protein levels: 24, 27 and 30% CP. A total of 270 fishes (135 males and 135 females – initial weight of 216.38 ± 26.73 g) were fed during 100 days, in a water re-use system containing 18 tanks (six treatments and three replicates). After this period, six fishes by treatment were captured for blood collection, by which the following values were obtained: hematocrit, hemoglobin, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and platelets. The males showed higher values (P<0.01) of red blood cells, hematocit and hemoglobin comparing to the females. The females showed higher platelet values. Platelets and mean corpuscular hemoglobin concentration were affected by dietetic protein level. Corpuscular volume and mean corpuscular hemoglobin were not affected by the diet protein level nor the fish sex (P>0.05). It can be concluded that jundiá fish males showed higher hematological parameters compared to females. The dietary protein influences in platelets and mean corpuscular hemoglobin concentration of jundiá fish.
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Mean corpuscular hemoglobin
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Iron deficiency anemia is common problem during pregnancy. Red cell size variation (anisocytosis) is the earliest morphologic changes in iron deficiency anemia. Red cell distribution width is a quantitative measure of red cell size variation and it can give the idea of early iron deficiency before other test to become positive. 190 pregnant women were included in this study. Red cell distribution width was compared between iron deficient & non-iron deficient pregnant women. Red cell distribution width also compared with Hb level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and peripheral blood film in prelatent iron deficiency, latent iron deficiency, mild and moderate iron deficiency anemia. Red cell distribution width had sensitivity 82.3% and specificity 97.4%. Whereas Hb level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and peripheral blood film all had 56.6%, 29.2%, 68.1%, 15% and 38.9% sensitivity but specificity was 90.9%, 98.7%, 83.1%, 96.1% and 98.7% in the detection of iron deficiency. Red cell distribution width appears to be a reliable and useful parameter for detection of iron deficiency during pregnancy.
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Objective: Elevated blood glucose may be affect complete blood count parameters. In this study, we compared the hemogram parameters of healthy individuals and cases with impaired glucose tolerance.
Method: We examineted 134 patients with impaired glucose tolerance and 30 healthy cases. Patients files were evaluated retrospectively and the levels of hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell, red cell distribution wide, mean platelet volume, platelet distribution wide, leukocycte, neutrophil, lymphocycte, platelet, and hemoglobin A1c were recorded. Control and patient groups were compared in terms of these parameters with student T test. In addition, the relationship between hemoglobin A1c value and complete blood count parameters were determined in patients with impaired glucose tolerance.
Results: There was no significantly difference between study and control groups in terms of hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell count, red cell distrubition wide, leukocycte, neutrophil, lymphocycte, platelet levels. The mean platelet volume and platelet distribution wide values were significantly higher in the patient group than the control group (p value: 0.002, p value: 0.04 respectively).
Conclusion: Complete blood count is an easy, inexpensive test that can be performed in most hospitals. If our study results are supported by other studies, some hemogram parameters may be used to diagnose of impaired glucose tolerance.
Mean corpuscular hemoglobin
Mean platelet volume
Complete blood count
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Background: Febrile seizures (FS) are the most common type of convulsion in young children. The predisposing factors are still under investigation; however, iron insufficiency might play a role in this regard. Objectives: Our objective was to determine the association between iron status and febrile seizure. Patients and Methods: This prospective case-control study was conducted among 109 children aged 6 months to 6 years and hospitalized for the first episode of FS. The case group was compared to a group of 70 age- and sex-matched controls admitted to the same ward with the same diagnosis of infection. The control and case groups were matched based on family history of FS, age, sex, temperature, cause of illness, erythrocyte sedimentation rate (ESR), white blood cells (WBC), and platelets. Venous blood samples were examined for complete blood count (CBC), serum iron, serum ferritin, and total iron-binding capacity. The CBC included measurements of red blood cell (RBC), hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), WBC, and platelets. Results: There were no significant differences between the study groups in terms of temperature, ESR, WBC, and platelets. The mean Hb, HCT, ferritin, iron, and MCH were significantly lower in the case group than in the control group. The mean level of MCV in the FS group was lower than the mean level of MCV in the control group, but the difference was not significant. Conclusions: Low levels of serum ferritin and iron might play a role in the pathogenesis of simple febrile seizure. Further longitudinal studies are clearly needed to confirm our findings.
Mean corpuscular hemoglobin
Complete blood count
White blood cell
Erythrocyte sedimentation rate
Venous blood
Mean platelet volume
Febrile seizure
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