The localization of an anti-tumour monoclonal antibody (791T/36) in gastrointestinal tumours
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Abstract Fifty-six patients with gastrointestinal cancers and four patients with benign colorectal tumours have been injected with radiolabelled anti-tumour monoclonal antibody (791T/36) to assess the degree of localization of the antibody by external scintiscanning and measurements on resected specimens. Twenty-nine patients with primary colorectal cancer showed increased uptake of the radiolabelled antibody in the resected tumours, with a tumour to normal tissue (T:NT) ratio of 2·5:1. All but two of fifteen patients with recurrent or metastatic tumour showed positive images of the deposits on external scintiscanning. Twelve patients with noncolonic gastrointestinal malignancy were studied and in only two patients were tumours demonstrated by external scanning. There were no positive images in four patients with benign colonic disease nor could increased uptake of radiolabelled antibody be demonstrated in the resected specimens. Immunohistology and autoradiography have shown that the antibody can be demonstrated in the pseudoacini and stroma of colon cancer. There are indications that this may represent localization to a cell surface antigen which becomes detached in the processing of the histological sections. It seems that in the gastrointestinal tract the monoclonal antibody 791T/36 is consistently taken up by colorectal cancer. Only a few noncolonic cancers and no benign colonic tumours take up the antibody. This antibody uptake may prove of value in the detection of occult metastases and in the targeting of antitumour agents.Keywords:
Gastrointestinal cancer
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Objective To observe the clinical effect and side reactions of HCPT+DDP+CF and 5-Fu on the treatment of phase Ⅳ gastrointestinal cancer.Methods 54 cases of phase Ⅳ gastrointestinal cancer were treated with the regimen of HCPT+DDP+CF and 5-Fu for more than two cycles.Results Three of 54 cases got the complete response and twenty two part response.The total response rate was 51.8%.The major side reactions were gastrointestional tract reaction,myelosuppression,temporary kidney functional damage and alopecia.Conclusion The regimen of HCPT+DDP+CF and 5-Fu is effective in the treatment of phase Ⅳ gastrointestinal cancer,and well tolerated.
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Gastrointestinal cancer
Large intestine
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Distinctive syndromes correlating skin manifestations and gastrointestinal malignancies are described. The skin lesions may precede, accompany, or follow the primary disease in the gastrointestinal tract and can be important diagnostic clues. They should alert the physician to the possibility that his patient may have an associated internal cancer.
Gastrointestinal cancer
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Gastrointestinal cancer
Cancer Treatment
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Objective: To explore the clinical significance of Ang-2 in the diagnosis of malignant tumor of gastrointestinal tract.Methods:The serum contents of Ang-2 in 56 cases of malignant tumors in gastrointestinal tract and 12 cases of healthy subjects were measured by ELISA.The results were analyzed with SPSS11.0.Results:The serum contents of Ang-2 in patients with malignant tumor in gastrointestinal tract were significantly higher than those in healthy group(P0.05).There was no difference in the content of serum Ang-2 between gastric cancer and intestinal malignant tumor(P0.05).Conclusion:It is valuable to determine the serum content of Ang-2 for diagnosis of malignant tumor in gastrointestinal tract.
Gastrointestinal cancer
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Gastrointestinal cancer
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Cancers of the gastrointestinal tract are one of the most rewarding interfaces in translational medicine—particularly on colorectal cancer—leading to greater understanding of the genetic mechanisms leading to cancer and the development of novel targeted therapies. Diagnosis of gastrointestinal tract cancers is usually made or suspected at endoscopy, confirmed by biopsy....
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The low plasma levels of vitamin A of patients with cancer of the gastrointestinal tract probably are not due to a decreased capacity of the livers of those patients to store the vitamin.
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