Motor activity and the GABAA-receptor in the ventral pallidum/substantia innominata complex
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Muscimol
Substantia innominata
Ventral pallidum
GABA receptor antagonist
Laryngeal motoneurons in the nucleus ambiguus were activated antidromically to ipsilateral recurrent nerve stimulation in urethane-chloralose anaesthetized rats. GABAA agonist muscimol and the antagonist bicuculline were applied separately or together with GABA iontophoretically with a multibarrel pipette glued with a recording electrode. The majority of neurons (119/155) which did not respond to the recurrent nerve stimulation exhibited activities mostly related to inspiration. Other 32 neurons were classified as laryngeal motoneurons, according to the criteria. Bicuculline application antagonized GABAA-mediated inhibition while muscimol or GABA reversed this effect significantly. Dose dependent changes were observed for administration of these GABAA-related agents. It can be concluded therefore that laryngeal motoneurons received GABAA-mediated inhibition.
Muscimol
GABA receptor antagonist
Nucleus ambiguus
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Muscimol
Picrotoxin
GABA receptor antagonist
Baclofen
Nipecotic acid
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Muscimol
Picrotoxin
GABA receptor antagonist
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Muscimol
Picrotoxin
GABA receptor antagonist
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Citations (2)
In unrestrained rats, frequency ranges of dorsal hippocampus electrograms were studied after intraventricular injections of the GABA, muscimol, baclofen, bicuculline and picrotoxin. The data obtained corroborates the idea of an interrelationship between the agonists and antagonists of the GABA receptors. A possibility of participation of these receptors in the formation and/or modulation of total electrical hippocampal activity, is discussed.
Muscimol
Picrotoxin
Baclofen
GABA receptor antagonist
GABAB receptor
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Muscimol
GABA receptor antagonist
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Muscimol
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Periaqueductal gray
GABA receptor antagonist
Escape response
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Muscimol
GABA receptor antagonist
Medial forebrain bundle
GABA receptor
Forebrain
Gamma-Aminobutyric Acid
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In the present study, muscimol (a GABA receptor agonist), bicuculline (aGABA receptor antagonist), nipecotic acid (an inhibitor of GABA uptake) and3-mercaptopropionic acid (an inhibitor of GABA synthesis) were injected intothe dorsal raphe nucleus of rats with chronically embedded cannula, the dose ofeach drug was 4μg/μl. The influences of such injection on pain threshold andanalgesic effect of acupuncture (AEA) were investigated. Injection of muscimol or nipecotic acid caused respectively a rise in painthreshold (+20%-+40%, P0.05 and P0.01) and a marked enhancementof AEA. These effect was found to be apparent for at least 2h. The pain thresholdwas insignificantly changed after injection of bicuculline or 3-mercaptopropionicacid (P0.05), but injection of either drug could cause a significant decline ofAEA (P0. 05 and P0. 01). These results indicated that GABA in dorsal raphenucleus played an important role in modulation of pain transmission.
Muscimol
Nipecotic acid
GABA receptor antagonist
Dorsal raphe nucleus
Picrotoxin
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Muscimol
Substantia innominata
Ventral pallidum
GABA receptor antagonist
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Citations (17)