Transport and metabolism of adenosine in the perfused human placenta

Placenta (1995)

C.G. Acevedo Sergio Rojas M. Ramírez Iván Bravo

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Keywords:

Hypoxanthine

Inosine

Topics:

Adenosine and Purinergic Signaling

Pregnancy and preeclampsia studies

Neonatal Health and Biochemistry

10.1016/0143-4004(95)90030-6

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Studies on the Mechanism of Antibody Formation

Nippon Saikingaku Zasshi (1968)

Kazunari HAGIWARA Tomiyoshi Ito Kazuaki FUJIMOTO Eiichi SAKAKIBARA

The present investigation was made to clarify the action of adrenalin on the formation of inosine, which was identified as antibody-promoting factor. The results obtained were as follows.Adrenalin displayed its action at two locations in the course of metabolic degradation of ATP and adenosine. At one location, it accelerated the degradation from ATP or adenosine to inosine and hypoxanthine, and at the other it inhibited the conversion from inosine and hypoxanthine to xanthine. Especially, when adrenalin and adenosine were used together, inosine and hypoxanthine were found to have increased about 1.7 times after incubation for 40-60 minutes, but xanthine did not behave in the same manner. The optimal rate of adrenalin was 100μg per ml of basic medium.

Hypoxanthine

Inosine

Xanthine

10.3412/jsb.23.822

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Compartmentation of cardiac adenine nucleotides and formation of adenosine

Pflügers Archiv - European Journal of Physiology (1976)

J�rgen Schrader E. Gerlach

Inosine

Hypoxanthine

Adenine nucleotide

Adenosine monophosphate

10.1007/bf00585148

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Citations (142)

Determination of rat cerebrospinal fluid concentrations of adenosine, inosine, hypoxanthine, xanthine and uric acid by high performance liquid chromatography

Journal of Pharmacy and Pharmacology (1988)

Gary A. Walter John W. Phillis Michael H O'Reagan

Abstract Isocratic reverse-phase high performance liquid chromatography techniques were developed to resolve and quantitate the purine nucleosides adenosine (Ado) and inosine (Ino) and their metabolites hypoxanthine (Hyp), xanthine (Xan), and uric acid (UA) in the cerebrospinal fluid of the rat. The moving phase composition for resolving hypoxanthine, xanthine and uric acid was a 0.22 M, pH 5.8 phosphate buffer. The moving phase composition for resolving adenosine and inosine was a 0.22 M, pH 6.8 phosphate buffer, 7% methanol (v/v) and 2.5 mM tetrabutylammonium phosphate. The observed cerebrospinal fluid concentrations in the rat were: Ado = 35 ± 9 nM (s.e.m.), Ino = 359 ± 85 nM, Hyp = 243 ± 77 nM, Xan = 1340 ± 423 nM and UA = 6130 ± 678 nM.

Hypoxanthine

Inosine

Xanthine

10.1111/j.2042-7158.1988.tb05201.x

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Citations (24)

Specificity of adenosine uptake into the heart and inhibition by dipyridamole

European Journal of Pharmacology (1970)

Norbert Kolassa K. Pfleger W. Rummel

Hypoxanthine

Inosine

Ribose