Probiotics andHelicobacter pyloriinfection*
Shigeru KamiyaMotomichi TakahashiTaki ManzokuKentaro OkaTakako OsakiTomoko HanawaSatoshi KurataHaruhiko Taguchi
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Abstract:
Probiotics involving Lactobacillus, Bifidobacterium, Saccharomyces, Clostridium butyricum, etc. have been reported to have inhibitory effects on Helicobacter pylori infections in in vitro and in vivo studies. In addition, these probiotics have been reported to be effective in clinical studies; the patients treated with triple therapy combined with probiotics had a higher H. pylori eradication rate than those with triple therapy only, and antibiotic-associated gastrointestinal side effects during H. pylori eradication therapy were reduced in the patients treated with a probiotics supplemented regimen. It was also reported that probiotic supplementation reduced side effects and permitted a slight improvement in eradicating H. pylori in second-line eradication therapy.Keywords:
Helicobacter Infections
Background: Long‐term acid suppression is believed to accelerate atrophic gastritis in Helicobacter pylori ‐positive patients. The influence of long‐term therapy with lansoprazole has not been examined. Aim: To study the clinical and endoscopic efficacy and histological evolution of gastric mucosa during 5 years of maintenance treatment with lansoprazole, 30 mg. Methods: Seventy‐eight patients with endoscopically proven oesophagitis were followed for 5 years. Biopsies taken at the start of the study, during follow‐up and after 5 years were available for 73 patients. Results: The total endoscopic relapse rate was 14.1%. At the start of the study, 34 patients were Helicobacter pylori negative and 39 were Helicobacter pylori positive (two atrophy, 25 antral gastritis, 12 pangastritis). At 5 years, no histological changes had occurred in Helicobacter pylori ‐negative patients. In the Helicobacter pylori ‐positive group, 20 patients developed pangastritis, six had normal histology and one had antral gastritis. Ten of the 12 patients with pangastritis had reduced antral activity. There was no increase in intestinal metaplasia, but there was a tendency towards regression of atrophy in the antrum and towards increased atrophy in the body of the stomach. Conclusions: Maintenance treatment with lansoprazole, 30 mg, is efficacious. The development of glandular atrophy and intestinal metaplasia was not accelerated in Helicobacter pylori ‐positive patients. Helicobacter pylori eradication must be considered only because of the higher cancer risk associated with chronic Helicobacter pylori ‐related gastritis.
Lansoprazole
Intestinal metaplasia
Helicobacter
Metaplasia
Atrophic gastritis
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Gastric biopsy
Helicobacter Infections
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Abstract Background: Various evidences have recently been provided indicating the relationship between infection with Helicobacter pylori and the extra-gastric complication, especially atherosclerosis. Atherosclerosis is the most important predisposing factor for cardiovascular disorders due to the high prevalence of cardiovascular disorders in developing countries (areas where a high population of people are infected with Helicobacter pylori ), in particular in Iran. Methods: In a current systematic review and meta-analysis study, we collected all studies of the isolation of Helicobacter pylori from atherosclerotic plaques in Iranian cardiovascular patients to investigate the presence or absence of a relationship between Helicobacter pylori infection and susceptibility to atherosclerosis. The present meta-analysis was done by Comprehensive Meta-Analysis software (CMA-Ver. 2.0). This software has the ability to combine studies and impact sizes into the results and is highly acceptable. Results: Overall, the frequency of H. pylori in atherosclerotic plaques in the coronary artery disease (CAD) patients was estimated to be 41.30%. However, the highest and lowest frequency of infection with Helicobacter pylori were 80% and 0%, respectively. Conclusions: However generally, regarding the previous studies, we collected all the Iranian published articles and showed that the infection with Helicobacter pylori was significantly related with the atherosclerosis, but further complementary and more extensive studies are required to confirm this hypothesis.
Helicobacter
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There are increasing data on the association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura and the significant increase in platelet count after bacterial eradication. The aim of this review was to consider the studies so far published on Helicobacter pylori infection and idiopathic thrombocytopenic purpura in order to evaluate a possible correlation between these two conditions. A review of the literature showed that 306 out of the 524 patients investigated (54.8%) were positive for Helicobacter pylori infection and that the bacterium was eradicated in 83% of cases. Eradication therapy was accompanied by a complete or partial platelet response in approximately half the cases. Overall, these data show that Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura is effective in increasing platelet count. However, since the studies so far published are few, sometimes controversial and involve small series of patients, further studies on larger numbers of patients with longer followup are needed to confirm these preliminary findings.
Thrombocytopenic purpura
Helicobacter
Purpura (gastropod)
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Purpose To identify the relationship betw een Helicobacter pylori and reflux esophagitis. Methods A case-control study was designed.Among 20 128 patients who accepted gastroscopic examination from March 2002 to Feb. 2004.Tho se 641 patients with reflux esophagitis were included in the case group,and 64 1 controls were selected from the same population by matching sex,age and endosc opic examination date.The Helicobacter pylori infection positive status of e ach patient was determined by positive result of either the rapid urease test or Gimsa staining. Results The rate of reflux esophagitis was 3.18% (641/2 0 128).The Helicobacter pylori positive rate was significantly lower in the case group (39.8%) than in the control group (45.7%,OR:0.785,95%CI:0.629-0.979 ) . Conclusions Helicobacter pylori infection may decre ase the occurrence of reflux esophagitis.
Reflux esophagitis
Esophagitis
Rapid urease test
Helicobacter
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【Objectives】To learn the status and analyze the related factors of helicobacter pylori infections in children in Changsha,and provide theory basis for prevention.【Methods】1890 0 to 5-year-old children were randomly selected to make seroepidemiological investigation on helicobacter pylori infections,and questionnaire was used to understand the related factors【.Results】Helicobacter pylori infection rate for children aged 0～15 in Changsha was 20.4%,the percentages of infection for male and female were 18.4% and 21.9%,respectively.There has an irregular increasing trend of helicobacter pylori infection rate with the increasing of age,and the age group 13～15 years showed the highest infection rate.However,the infection rate of helicobacter pylori is decreased with the increasing of family income,but the rate was increasing in highest family income group.Hp infection rate of children whose parents have a history of gastric ulcer was significantly higher than children whose parents without a history of gastric ulcer.There have statistical differences.【Conclusions】Helicobacter pylori infection rates for children aged 0～15 in Changsha at the middle level,and Hp infection correlated to age,family income,family gastric ulcer.Helicobacter pylori infection was irregular increasing with the increasing of age and the decreasing of family income.Familial aggregation of Helicobacter pylori infection was shown in this study.
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Helicobacter
Family income
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Helicobacter Infections
Spirillaceae
Helicobacter
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