The Relationship Between Helicobacter pylori and Reflux Esophagitis(A Case - Control Study)
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Purpose To identify the relationship betw een Helicobacter pylori and reflux esophagitis. Methods A case-control study was designed.Among 20 128 patients who accepted gastroscopic examination from March 2002 to Feb. 2004.Tho se 641 patients with reflux esophagitis were included in the case group,and 64 1 controls were selected from the same population by matching sex,age and endosc opic examination date.The Helicobacter pylori infection positive status of e ach patient was determined by positive result of either the rapid urease test or Gimsa staining. Results The rate of reflux esophagitis was 3.18% (641/2 0 128).The Helicobacter pylori positive rate was significantly lower in the case group (39.8%) than in the control group (45.7%,OR:0.785,95%CI:0.629-0.979 ) . Conclusions Helicobacter pylori infection may decre ase the occurrence of reflux esophagitis.Keywords:
Reflux esophagitis
Esophagitis
Rapid urease test
Helicobacter
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Objective To investigante the association between Helicobacter pylori(Hp) infection and reflux esophagitis.Methods 202 patients with reflux esophagitis and 240 controls were enrolled in this study.Serum samples from these patients were tested for specific IgG antibodies to Hp,using enzyme-linked immunosorbent assay(ELISA).Gastric biopsy specimens obtained during endoscopy were used for pathological and rapid urease test.Results The ratio of the Hp infection was 20.30% in patients with reflux esophagitis and 43.33% in the controls.There was signifcant difference between the two groups.Conclusion There was a negative correlation between Hp infection and reflux esophagitis.
Reflux esophagitis
Esophagitis
Rapid urease test
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Esophagitis
Rapid urease test
Reflux esophagitis
Urea breath test
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Background/Aims: Helicobacter pylori (H. pylori) has been generally accepted as the main etiologic factor in gastrointestinal disease. However, some recent reports suggest a protective role of H. pylori in gastroesophageal reflux disease. We assessed the H. pylori prevalence in reflux esophagitis and development rate of reflux esophagitis after H. pylori eradication. Methods: A total of 398 patients (173 reflux esophagitis patients and 225 chronic gastritis or peptic ulcer patients) from 1998 through 2000 were included in this study. Reflux esophagitis was graded from A to giaccording to the Los Angeles (LA) classification. Among these patients, 86 patients (is cured group and 39 ongoing infection group) underwent H. pylori eradication and subsequent follow-up endoscopy. Results: The rate of H. pylori infection was significantly lower in reflux esophagitis group than in control group (47.3% vs 65.7%, p=0.000l). There was no significant difference in the H. pylori infection rate according to the grade of esophagitis (LA-A 40.3%, LA-B 59.1%, LA-C 50.0%, LA-D 28.6%; p=0.094). After H. pylori eradication therapy, reflux esophagitis was newly developed in 4 cases (8.5%) of cured group and 2 cases (5.1 %) of ongoing infection group. Conclusions: There may be no protective role of H. pylori in reflux esophagitis.
Reflux esophagitis
Esophagitis
Peptic
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This study aimed to evaluate the possible effects of Helicobacter pylori (H. pylori) infection in reflux esophagitis with scleroderma.There were a total of 138 patients with scleroderma in our hospital between October 1998 and June 2005. Among these patients, 64 consecutive patients of scleroderma, who did not receive medication for gastrointestinal diseases, underwent endoscopy after informed consent. H. pylori was examined using an H. pylori IgG ELISA. The endoscopists graded esophageal mucosal breaks according to the Los Angeles Classification of Esophagitis.Among the 64 patients, 37 patients (57.8%) were positive for H. pylori infection. Reflux esophagitis was observed in 10 of 37 H. pylori-positive patients and in 19 of 27 H. pylori-negative patients. Significantly fewer H. pylori-infected patients had reflux esophagitis than H. pylori-negative patients (p<0.01). The odds ratio for H. pylori infection and reflux esophagitis was 0.16 (95%CI; 0.052-0.47).These findings suggest an important role for H. pylori infection in reflux esophagitis with scleroderma.
Reflux esophagitis
Esophagitis
Scleroderma (fungus)
Helicobacter Infections
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Objective To investigate the correlation between reflux esophagitis and Helicobacter pylori infection in patients with gastric cancer.
Methods
From August 2015 to January 2017, 45 patients with gastric cancer treated in People's Hospital of Xinjiang Uygur Autonomous Region and 45 patients with reflux esophagitis treated with gastric cancer in our hospital during the same period were enrolled in this study. Helicobacter pylori Infection rate, and Helicobacter pylori infection and reflux esophagitis correlation analysis.
Results
The incidence of Helicobacter pylori infection in patients with gastric cancer complicated with reflux esophagitis and gastric cancer were 22.22% and 88.89%, respectively, with significant difference (χ2=15.568, P＜0.05). Helicobacter pylori infection in gastric cancer with reflux esophagitis was lower than in patients with gastric cancer.
Conclusion
Helicobacter pylori infection in gastric cancer patients may have a protective effect on the pathogenesis of reflux esophagitis.
Reflux esophagitis
Esophagitis
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Objective Study on the relationship between helicobacter pylori(HP) infection and reflux esophagitis.Methods Select Group of reflux esophagitis(286) and control groups(240),the use of anti-HP-IgG antibody serological testing,rapid urease test for detection of HP infection and pathology.Results HP infection rate in patients with reflux esophagitis is 20.3%,while the control group 43.3%(P0.05).Conclusion HP infection and reflux esophagitis in inverse correlation exists.
Reflux esophagitis
Esophagitis
Rapid urease test
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[Objective]To investigate the correlation between reflux esophagitis(RE)and Helicobacter pylori(Hp).[Methods]One hundred and twenty-five patients with RE and 70 normal controls were collected in the study.Two pieces of living tissues from greater and lesser curvature of gastric antrum respectively were obtained to detect Hp infection by urease test and biopsy.[Results]The infective rate of Hp was 35.24% in RE patients and 63.33% in controls.The difference between them was significant(P0.05).[Conclusion]Hp may have a protective effect against RE.
Reflux esophagitis
Rapid urease test
Esophagitis
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Objective: To investigate the relationship between Helicobacter pylori (Hp) infection and reflux esophagitis (RE). Methods: Ninety-seven patients identified as reflux esophagitis by gastroscopy were retrospectively analyzed, and 104 controls with chronic gastritis were enrolled in this study. 14C breath test was used for Hp detection. Results: The ratio of the Hp infection was 45.4% in patients with reflux esophagitis and 63.5% in the controls (P0.01). The ratio of the Hp infection of RE A, B, C grade were 59.4%, 42.0% and 26.7% respectively,and there was no obvious difference among those groups (P0.05). Conclusion: Hp infection may be a protective factor for RE.
Reflux esophagitis
Esophagitis
Chronic gastritis
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Objective To identify the relationship between Helicobacter pylori and reflux esophagitis.Methods Among 7230 patients who accepted gastroscopic examination from Feb.1997 to Feb.2003,6885 patients was analyzed who were enrolled in the study and divided 4 groups by matching sex and age.(1) 298 controls were selected from the control group;(2) those 588 patients with duodenal ulcer alone group;(3) those 167 patients with reflux esophagitis were included in the RE-group;(4) those 26 patients with reflux esophagitis with duodenal ulcer group by the same population.The Helicobacter pylori infection positive status of each patient was diagnosed by positive result of the rapid unease test and warthinstary staining. Results The Helicobacter pylori positive rate was 45.64%,71.77%,36.52% and 38.46% respectively in these 4 groups.Helicobacter pylori positive rate was significantly lower in the RE-group than in the DU group(χ~2=70.087,P=0.000),and the was significantly higher in the DU group than in the DU+RE group(χ~2=13.246,P=0.00)?There was no significant difference in Helicobacter pylori positive rates between the control group and the RE-group(χ~2=3.638,P=0.35).Conclusion It shouldn' t be denied that Helicobacter pylori has a potential protective effect on esophagus,Helicobacter pylori infection may decrease the occurrence of reflux esophagitis.
Reflux esophagitis
Esophagitis
Helicobacter
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Some studies suggest that Helicobacter pylori (H. pylori) infection would be a protective factor for the gastroesophageal reflux. The aim of this study was to explore this fact. A group of 72 children, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with gastroesophageal reflux by 24-hour continuous esophageal pH monitoring (results were interpreted using the Boix-Ochoa score), underwent upper endoscopy with gastric biopsy to detect the presence of H. pylori by the rapid urease testing and for bacteriological and histologic examination. 19 children (26.39%) had H. pylori infection, while 53 (73.61%) did not. The grade of esophagitis was classified according to the Los Angeles classification system. Out of 47 children with esophagitis A, 16 (34.04%) had H. pylori infection, while out of the 25 children with esophagitis B, only 3 (12%) had H. pylori infection, with statistic significance (χ2 = 54.69, P << 0.05, 95% confidence interval [CI]). Regarding the value of the Boix-Ochoa score, it appears that the presence of the H. pylori determines lower pH-metry scores (F = 8.13, P = 0.0015, 95% CI). The presence of the H. pylori was not an important factor in the gastroesophageal reflux. On the other hand its relationship with esophagitis appears to be inverse ratio. The fact that the H. pylori presence is statistically greater in the grade A esophagitis could confirm the hypothesis that the bacteria would slow down the development of the esophagitis.
Esophagitis
Reflux esophagitis
Rapid urease test
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