Disproportional exaggerated aspartate transaminase is a useful prognostic parameter in late leptospirosis
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AIM:To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually.However, sequential follow-up of liver biochemical data remained lacking.. METHODS:The biochemistry data and clinical symptoms of 11 sporadic patients were collected and analyzed, focusing on the impacts of leptospirosis upon liver biochemistry tests. RESULTS:The results disclosed that of the 11 cases, 5 or 45% died.The liver biochemistry data in the beginning of the disease course were only mildly elevated.Nevertheless, late exaggerated aspartate transaminase (AST) elevations were noted in three cases who finally died when compared with the typical course.Besides, significant higher AST/alanine transaminase (ALT) ratios (AARs) of the peak levels for transaminase were also noted in the cases who eventually succumbed.The mean±SD of AARs for the survival group and dead group were 5.65±2.27(n = 5) and 1.86±0.64(n = 6) respectively (P = 0.006).The ratios of the cases who finally died were all more than 3.0.Conversely, the survival group's ratios were less than 3.0. CONCLUSION:Serial follow-up of transaminase might provide evidence to predict some rare evolutions in leptospirosis.If AST elevated progressively without a concomitant change of ALT, it might indicate an acute disease course with ensuing death.Additionally, AAR is another prognostic parameter for leptospirosis.Once the value was higher than 3.0, a grave prognosis is inevitable.Keywords:
Aspartate transaminase
Transaminase
Concomitant
Elevated transaminases
Alanine aminotransferase
Liver disease
AIM:To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually.However, sequential follow-up of liver biochemical data remained lacking.. METHODS:The biochemistry data and clinical symptoms of 11 sporadic patients were collected and analyzed, focusing on the impacts of leptospirosis upon liver biochemistry tests. RESULTS:The results disclosed that of the 11 cases, 5 or 45% died.The liver biochemistry data in the beginning of the disease course were only mildly elevated.Nevertheless, late exaggerated aspartate transaminase (AST) elevations were noted in three cases who finally died when compared with the typical course.Besides, significant higher AST/alanine transaminase (ALT) ratios (AARs) of the peak levels for transaminase were also noted in the cases who eventually succumbed.The mean±SD of AARs for the survival group and dead group were 5.65±2.27(n = 5) and 1.86±0.64(n = 6) respectively (P = 0.006).The ratios of the cases who finally died were all more than 3.0.Conversely, the survival group's ratios were less than 3.0. CONCLUSION:Serial follow-up of transaminase might provide evidence to predict some rare evolutions in leptospirosis.If AST elevated progressively without a concomitant change of ALT, it might indicate an acute disease course with ensuing death.Additionally, AAR is another prognostic parameter for leptospirosis.Once the value was higher than 3.0, a grave prognosis is inevitable.
Aspartate transaminase
Transaminase
Concomitant
Elevated transaminases
Alanine aminotransferase
Liver disease
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Drug-induced liver injury was most common in clinical therapy.The levels of alanine transaminase(ALT)and aspartate transaminase(AST)in 1242 in-patient children and 953 healthy chidren were analyzed in this paper.A significantly high levels of AST and ALT activity (more than 40IU/L)were observed in in-patient children,being 26.08% and 31.00% as com- pared to that of 3.99% and 3.16% in healthy children,respectively,showing significant difference.
Aspartate transaminase
Transaminase
Alanine aminotransferase
Liver enzyme
Elevated transaminases
Aspartate Aminotransferases
Alanine
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Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. ALT is found in plasma and in various body tissues but is most common in the liver. It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
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Alanine aminotransferase
Aspartate transaminase
Alanine
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Elevation of transaminases has been used as a marker of hepatic ischemic injury and as a crucial parameter for liver graft assessment. However, analysis of serum transaminases has limitations regarding the quantitative assessment of liver necrosis and is not a reliable predictor of outcomes.We retrospectively reviewed the medical records of all liver transplants (N = 238) performed at the UMass Memorial Medical Center from 2009 to 2013.Fourteen liver grafts showed high peak aminotransferases alanine aminotransferase (ALT) and aspartate aminotransferase (AST) at > 1000 U/L. This high aminotransferase group was compared with 224 donors with low transaminase levels (ALT/AST < 1000 U/L). The high transaminase donors had a median peak AST level of 3216 U/L (range, 1823-13?030 U/L) and ALT level of 2677 U/L (range, 812-7080 U/L). The high transaminase donors showed higher levels of lactate dehydrogenase, international normalized ratio, total bilirubin, and gamma-glutamyltransferase compared with low transaminase donors; however, only lactate dehydrogenase results reached statistical significance. None of the grafts from the high transaminase donors showed primary nonfunction. Three-year graft and patient survival rates were similar in both groups (75% vs 80% [P = .48] and 72% vs 82% [P = .33], respectively). In an analysis of the discard rate of livers over a 10-year period in the United States using the Scientific Registry of Transplant Recipients database, the discard rate of livers with high aminotransferase levels was 69.14% compared with 22.23% for livers with low transaminase levels.Liver grafts from donors with high transaminase levels can lead to clinical results that are similar to liver grafts from donors who had lower peak transaminase levels.
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Elevated transaminases
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Objective To explore the correlation analysis of transaminase elevation on pregnant woman.Methods A retrospective analyzed the clinical date of 142 childbearing age women with normal physical examination in clinic and 244 cases of pregnant women who were treated in our hospital from December 2011 to December 2012.The serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),alkaline phosphatase(ALP) and total bile acid(TBA) were detected and analyzed.Results The serum TBIL and TBA content in pregnant women with normal transaminase and childbearing age women had no significant difference(P0.05),ALT had significant difference(P 0.01).The TBIL,TBA and ALT content in pregnant women with normal and elevatory transaminase all had significantly difference(P 0.05).And when transaminase elevated in pregnant women,TBIL and TBA increased to 21.7% and 61.4%,and ALP in all pregnant women increased.Thus transaminase elevation in pregnant women had a higher correlation with TBA elevation.Conclusion In the exclusion of primary hepatic disease,pregnancy-induced hypertension and other organic disease,if pregnant women had transaminase elevation associated with TBA elevation significantly without pruritus and jaundice,it can be diagnosed as early ICP.Because ALP increased in all the pregnant women,ALP has no specificity in the diagnosis of ICP.
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Aspartate transaminase level was significantly increased in intestine of experimentals that received multiple doses of infection. The level of alanine transaminase rose to a significant value in liver of mice infected with multiple doses. Rise of transaminases is correlated with the necrosis (disruption of intestina) hepatic cells in infected mice. Changes and/or the distribution of aspartate transaminase and alanine transaminase with regard to the dosage is discussed.
Aspartate transaminase
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Ancylostoma caninum
Alanine aminotransferase
Elevated transaminases
Aspartate Aminotransferases
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Objective: To explore the risk factors and regularity of pediatric primary Epstein-Barr virus (EBV) infection accompanied with elevated transaminase. Methods: Clinical data of 399 children diagnosed as primary EBV infection in the outpatient department, Children's Hospital of Fudan University from September 2016 to October 2017 were analyzed retrospectively. Logistic regression analysis was performed to determine the potential correlations between elevated alanine transaminase (ALT) or aspartate transaminase (AST) and age, gender, course of fever and plasma EBV-DNA load. The cumulative rates of elevated transaminase recovery to nomal at different times were caculated. Results: Among 399 children diagnosed with primary EBV infection, there were 219 males and 180 females. The age was (4.2±2.7) years. Among all cases, 51.9% (207/399) had elevated transaminase. In patients who had elevated ALT, 74.5% (149/200), 21.0% (42/200) and 4.5% (9/200) had mild (40-160 U/L), moderate (160-400 U/L) and severe (>400 U/L) elevation of ALT, respectively. In patients who had elevated AST, 83.8% (155/185), 11.9% (22/185) and 4.3% (8/185) had mild (40-160 U/L), moderate (160-400 U/L) and severe (>400 U/L) elevation of AST, respectively. Only age was correlated with the occurrence of elevated transaminase (OR=1.13, 1.10, both P<0.05). A total of 167 repeated tests were ordered in patients with elevated ALT and/or AST, including 113 cases with elevated ALT and 104 cases with elevated AST. The time of ALT and AST returned to normal were (24±13) days and (25±18) days respectively. The cumulative rates for ALT returned to normal within 1, 1-<4, 4-<8 weeks and more than 8 weeks were 2.7% (3/113), 54.0% (61/113), 79.6% (90/113) and 81.4% (92/113) respectively, and were 1.9% (2/104), 48.1% (50/104), 71.2% (74/104) and 74.0% (77/104) for AST. Conclusions: Age is a risk factor for transaminase elevation associated with primary EBV infection in children. The transaminases returned to normal within 3 weeks in half of the cases, and within 8 weeks in most cases.
Transaminase
Aspartate transaminase
Elevated transaminases
Alanine aminotransferase
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Elevated serum transaminase [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] levels have been reported in human immunodeficiency virus (HIV)-infected patients on combination antiretroviral therapy (cART). 100 female patients referred to Virology department of the Jos University teaching Hospital (JUTH), were randomly selected by their physicians on the basis of the following criteria: documented HIV infection, no alcohol abuse (≤ 20 g alcohol daily and no history of chronic alcohol consumption), no history of hereditary and autoimmune liver disease, no evidence of hemochromatosis.Patients with any contraindication for liver biopsy were excluded.Data on demographics, drug or alcohol use, and history of liver diseases were obtained at first visit.Subjects were then classified into control (30), HIV-infected; not on drugs (35) HIV-infected; on drugs ( 35);a month-by-month documentation of the prescribed drug combination for patients who started medication, provided an avenue for calculating each patient's individual cumulative drug exposure.The test for HIV antibodies, HBsAg were carried out on day one (at first visit) serum ALT and serum AST were determined three (3) months after detection (day 90; after HIV antigen confirmatory test).patients started medication at day one and 35 decided not to start medication until after confirmatory test (three months later).The serum ALT levels of the HIV infected patients on drugs (M=43.94,SD=4.30) was significantly higher than the serum ALT levels of the control group (M=29.17,SD=6.17), t (63) = 10.72,p < .0001at p <.005 confidence level.In a similar trend, the serum ALT levels of the HIV infected patients not on drugs (M=41.17,SD=2.06) was significantly higher than the serum ALT levels of the control group (M=29.17,SD=6.17), t (63) =10.05, p < .0001at p <.005 confidence level.On comparison, the serum ALT levels of the HIV infected patients on drugs (M=43.94,SD=4.30) was significantly higher than the serum ALT levels of the HIV infected patients not on drugs (M=41.17,SD=2.06), t (68) = 3.44, p < .0001at p <.005 confidence level.The serum AST levels of the HIV infected patients on drugs (M=44.54,SD=4.85) was significantly higher than the serum AST levels of the control group (M=32.23,SD=5.93), t (63) =9.21, p < .0001at p <.005 confidence level.In a similar manner, the serum AST levels of the HIV infected patients not on drugs (M=39.91,SD=1.67) was significantly higher than the serum AST levels of the control group (M=32.23,SD=5.93), t (63) =7.33, p < .0001at p <.005 confidence level.On comparison, the serum AST levels of the HIV infected patients on drugs (M=44.54,SD=4.85) was significantly higher than the serum AST levels of the HIV infected patients not on drugs (M=39.91,SD=1.67), t (68) = 5.34, p < .0001at p <.005 confidence level.A correlation plot between ALT and AST levels showed a non-significant correlation between these transaminases in the three groups.Control group (r = 0.098, p < 0.05), HIV (+ve), and HBV (-ve) patients on drugs (r = -0.038,p < 0.05), HIV (+ve), and HBV (-ve) patients not on drugs (r = 0.201, p < 0.05).It has been observed from the study that a significant elevation of liver transaminase levels (ALT and AST) is a serious risk factor associated with management of HIV management with drugs.
Alanine aminotransferase
Aspartate transaminase
Transaminase
Alanine
Aspartate Aminotransferases
Elevated transaminases
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AIM: To evaluate the hepatic dysfunction in leptospirosis is usually mild and resolved eventually. However,sequential follow-up of liver biochemical data remained lacking..METHODS: The biochemistry data and clinical symptoms of 11 sporadic patients were collected and analyzed, focusing on the impacts of leptospirosis upon liver biochemistry tests.RESULTS: The results disclosed that of the 11 cases, 5 or 45% died. The liver biochemistry data in the beginning of the disease course were only mildly elevated.Nevertheless, late exaggerated aspartate transaminase (AST)elevations were noted in three cases who finally died when compared with the typical course. Besides, significant higher AST/alanine transaminase (ALT) ratios (AARs) of the peak levels for transaminase were also noted in the cases who eventually succumbed. The mean±SD of AARs for the survival group and dead group were 5.65±2.27 (n = 5)and 1.86±0.64 (n = 6) respectively (P= 0.006). The ratios of the cases who finally died were all more than 3.0.Conversely, the survival group's ratios were less than 3.0.CONCLUSION: Serial follow-up of transaminase might provide evidence to predict some rare evolutions in leptospirosis. If AST elevated progressively without a concomitant change of ALT, it might indicate an acute disease course with ensuing death. Additionally, AAR is another prognostic parameter for leptospirosis. Once the value was higher than 3.0, a grave prognosis is inevitable.
Aspartate transaminase
Transaminase
Elevated transaminases
Concomitant
Alanine aminotransferase
Liver disease
Cite
Citations (0)
Objective To investigate the relationship between transaminase anomaly and prognosis. in severe brain injury. Methods Total 117 cases with severe traumatic brain injury from January 2010 to June 2012 were admitted and detect the blood level of the alanine transarninase (ALT) and glutamic-oxal(o)acetic transaminase (AST). Transaminase anomaly included ALT 50 U/L and (or) AST 50 U/L. According to the test results, they were divided into transaminase anomaly group and normal group. The level of ALT, AST and different GOS prognostic score were compared in both groups. Results The favorable prognosis rate in transaminase anomaly group was lower than that of the normal group (χ2=4.71, P0.05), with the mortality higher than that of normal group (χ2=5.42, P0.05). The level of ALT and AST in transaminase anomaly group was significantly related with GOS prognosis, and the higher transaminase level is, the worse the prognosis. Conclusion Transaminase elevated level are often contributed to severe traumatic brain injury. The careful monitoring and protection of the liver function have a favorable effect on improvement of the prognosis of brain injury patients.
Transaminase
Aspartate transaminase
Alanine aminotransferase
Elevated transaminases
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