O-38 TEG and thrombin generation during coronary artery bypass grafting: a comparison between on-pump and off-pump techniques

non-bleeders (n 41): PAI-1 19 8.3 vs. 29 13, P 0.001; t-PA/PAI-1 3 1.4 vs. 4.2 2.4, P 0.012. Bleeders showed a significantly higher level of D-dimers 1, 6 and 24 hr after surgery: at T1 318 vs. 228, P 0.05; at T6 – 333 vs. 234, P 0.03; at T24 – 300 vs. 197, P 0.007. Discussion. A preoperative level of PAI-1 and postoperative level of t-PA/PAI-1 complex just after surgery may lead to higher levels of D-dimer later on and are associated with an increased bleeding tendency after cardiac surgery.