PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

Robert S. Banh,Caterina Iorio,Richard Marcotte,Yang Xu,Dan Cojocari,Anas M. Abdel Rahman,Judy Pawling,Wei Zhang,Ankit Sinha,Christopher M. Rose,Marta Isasa,Shuang Zhang,Ronald Wu,Carl Virtanen,Toshiaki Hitomi,Toshiyuki Habu,Sachdev S. Sidhu,Akio Koizumi,Sarah E. Wilkins,Thomas Kislinger,Steven P. Gygi,Christopher J. Schofield,James W. Dennis,Bradly G. Wouters,Benjamin G. Neel

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

2016

Banh et al. show that PTP1B decreases non-mitochondrial oxygen consumption by regulating the RNF213/α-KGDD pathway, thus promoting hypoxic survival of cancer cells.

Keywords:

Cancer cell
Cancer Microenvironment
Cell biology
Oxygen
Cancer
Biology
Hypoxia (medical)
Cell hypoxia
Extramural
Protein tyrosine phosphatase
Mitochondrion

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