Modelling thrombopoiesis regulation—I: Model description and stimulation results

Abstract This paper gives a detailed account of the authors' mathematical model of thrombopoiesis regulation. A special feature of the model is the consequent use of Von Foerster's partial differential equation for the description of age-structured compartments, where regulation effects are built into the Von Foerster growth coefficient. For the computer solution of the model equations—which include ordinary as well as partial differential equations—the authors developed an approximation scheme. Results of computer simulation of the model are also presented.