ThermoplasmonicOptical Fiber for Localized NeuralStimulation
2020
Thermoplasmonic
effect-based neural stimulation has been suggested
as an alternative optical neural stimulation technology without genetic
modification. Integration of near-infrared light with plasmonic gold
nanoparticles has been demonstrated as a neuromodulation tool on in vitro neuronal network models. In order to further test
the validity of the thermoplasmonic neural stimulation across multiple
biological models (in vitro, ex vivo, and in vivo) avoiding genetic modification in
optical neuromodulation, versatile engineering approaches to apply
the thermoplasmonic effect would be required. In this work, we developed
a gold nanorod attached optical fiber technology for the localized
neural stimulation based on a thermoplasmonic effect. A simple fabrication
process was developed for efficient nanoparticle coating on commercial
optical fibers. The thermoplasmonic optical fiber proved that it can
locally modulate the neural activity in vitro. Lastly,
we simulated the spatiotemporal temperature change by the thermoplasmonic
optical fiber and analyzed its applicability to in vivo animal models.
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