Immunomodulatory potential of mesenchymal stem cell role in diseases and therapies: A bioengineering prospective

Abstract Stem cell-based therapies are promising solutions to tackle several conditions. In particular, mesenchymal stem cells (MSCs) own very unique characteristics that have often been described as a “cure-all”. In addition to their differentiation capacity, MSCs have demonstrated both trophic and immunomodulatory suppression of inflammation. These properties have been exploited to develop cellular therapies for different inflammatory-related pathologies. In this review, we describe how to utilize the immunosuppressive potential of MSCs for regenerative purposes and cancer therapy. Moreover, we report innovative approaches from tissue engineering and nanomedicine that demonstrate MSCs’ potential to improve their clinical translation.