Histone deacetylase and Cullin3–REN KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

Hedgehog signalling and activation of its downstream effectors Gli1/2 is deregulated in tumorigenesis. Hedgehog-induced HDAC1 is shown to activate Gli1/2 through its deacetylation. This effect is negatively regulated by the Cullin3/RENKCTD11 ubiquitin ligase, a Gli antagonist that is often lost in human medulloblastoma.