Abstract IA12: Coordination of mRNA processing, translation, and metabolism by mTORC1

The mTOR complex 1 (mTORC1)–S6 protein kinase (S6K1) signaling pathway has evolved to sense and respond to changes in growth factor and hormone-dependent signaling, cellular energy status, nutrient availability, and surrounding oxygen concentrations. A major mechanism through which mTOR regulates downstream processes is via the coordinated regulation of gene expression, mRNA biogenesis, protein synthesis, and protein degradation. I will discuss our studies linking mTORC1/S6K1 to mRNA processing, metabolism, and cancer progression. Citation Format: John Blenis, Gina Lee, Sungyun Cho, Yuxiang Zheng, Cholsoon Jang, Lew Cantley, Joshua Rabinowitz, Noah Dephoure. Coordination of mRNA processing, translation, and metabolism by mTORC1 [abstract]. In: Proceedings of the AACR Special Conference on Targeting PI3K/mTOR Signaling; 2018 Nov 30-Dec 8; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(10_Suppl):Abstract nr IA12.