DETECTION AND DISTRIBUTION OF CHLOROQUINE METABOLITES IN HUMAN TISSUES
1962
Metabolic products of chloroquine in human tissues and urine were studied by paper chromatography with the aid of ultraviolet spectroscopy, and the distribution of the products in tissues was examined based on chromatograms obtained. The results suggest that the drug undergoes slow metabolic conversions in man along a major pathway involving oxidations on the side chain which leads to the formation of 4-amino-7-chloro-quinoline.
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